Xenotransplantation: The Transplantation of Organs and Tissues Between Species

Front Matter....Pages I-XXXIV
Front Matter....Pages 1-1
Introduction....Pages 2-5
Front Matter....Pages 7-7
Hyperacute Xenograft Rejection....Pages 8-16
Role of Natural Antibody-Antigen Interactions in Xenotransplantation....Pages 17-23
Major Carbohydrate Xenotransplantation Antigens....Pages 24-32
Natural Antibody Polymorphism and Anti-Galα1–3Gal Antibodies....Pages 33-37
Role of Complement in Xenograft Rejection....Pages 38-60
Genetic Control of Humoral Responses to Xenografts....Pages 61-76
Mechanisms of Delayed Xenograft Rejection....Pages 77-94
Anti-αgalactosyl (Anti-Gal) Antibody Damage Beyond Hyperacute Rejection....Pages 95-103
Human Natural Killer Cells and Natural Antibodies Recognize Overlapping Molecular Structures on Discordant Xenogeneic Endothelium....Pages 104-125
Hemostasis in Xenotransplantation....Pages 126-139
Mechanism of Cellular Xenograft Rejection....Pages 140-174
Human T Cell Response to Porcine Tissues....Pages 175-189
Cellular Interactions in Discordant Xenotransplantation....Pages 190-198
Immunoprivileged Sites for Allo-and Xenotransplantation....Pages 199-205
Immunobiology of Xenotransplantation in Rodents....Pages 206-225
Front Matter....Pages 227-227
Histopathology of Kidney Xenograft Rejection....Pages 228-254
Histopathology of Cardiac Xenograft Rejection....Pages 255-272
Mechanism of Discordant Cardiac Xenograft Rejection — An Alternative View Based on Ultrastructural Observations....Pages 273-286
Histopathology of Liver Xenotransplantation in the Nonhuman Primate....Pages 287-302
Front Matter....Pages 227-227
Immunopathology of Discordant Xenograft Rejection....Pages 303-313
Front Matter....Pages 315-315
Experimental Concordant Kidney Xenotransplantation in Primates....Pages 316-322
Experimental Concordant Liver Xenotransplantation in Nonhuman Primates....Pages 323-327
Use of Tacrolimus (FK506) and Antimetabolites as Immunosuppressants for Xenotransplantation Across Closely Related Rodent Species....Pages 328-338
Front Matter....Pages 339-339
Roles of Anti-αGal Antibody and Oligosaccharide Therapy in Xenotransplantation....Pages 340-359
Removal of Natural Antibodies by Immunoadsorption: Results of Experimental Studies....Pages 360-376
Neutralization of the Cytotoxic Effect of Anti-αGal Antibodies with Monoclonal Anti-idiotypic Antibodies....Pages 377-386
Designer Tissues and Organs: Mouse to Man....Pages 387-398
Use of Anti-μ Monoclonal Antibodies in Xenotransplantation: A Potential Approach To Overcome Vascular Rejection....Pages 399-410
Use of Intravenous Immunoglobulin as a Therapeutic Approach To Prevent Rejection Between Widely Disparate Species....Pages 411-418
Control of Complement-Mediated Tissue Damage by γ-Globulin: Application in Xenotransplantation....Pages 419-424
Prolongation of Xenograft Survival by Cobra Venom Factor....Pages 425-436
Therapeutic Effect of Soluble Complement Receptor Type 1 in Xenotransplantation....Pages 437-455
Immunobiology of Pig-to-Baboon Lung Xenotransplantation....Pages 456-462
Experimental Lung Xenografting....Pages 463-477
Newborn Pig-to-Baboon Cardiac Xenotransplantation: A Model of Delayed Xenograft Rejection....Pages 478-487
Total Lymphoid Irradiation - Immunosuppressive Therapy for Xenotransplantation....Pages 488-495
Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation....Pages 496-518
Chimerism and Tolerance as an Approach to Xenotransplantation....Pages 519-531
Front Matter....Pages 533-533
Introduction....Pages 534-544
Front Matter....Pages 533-533
Isolated Pancreatic Islet Xenografting....Pages 545-564
Recent Approaches to the Isolation of Adult Porcine Islets of Langerhans....Pages 565-579
Xenotransplantation of Encapsulated Pancreatic Islets....Pages 580-600
Front Matter....Pages 601-601
Pharmacologic Immunosuppressants in Xenotransplantation....Pages 602-633
Use of Brequinar Sodium To Prevent Xenograft Rejection....Pages 634-640
Leflunomide and the Malononitriloamides in Xenotransplantation....Pages 641-648
Front Matter....Pages 649-649
Use of Transgenic Animals as Xenotransplant Donors....Pages 650-658
Engineering of Xenografts To Provide Organs for Human Transplantation....Pages 659-664
Effect of Transgenic Expression of Human Decay—Accelerating Factor on the Inhibition of Hyperacute Rejection of Pig Organs....Pages 665-682
Overcoming the Anti-Galα(1–3)Gal Reaction To Avoid Hyperacute Rejection: Molecular Genetic Approaches....Pages 683-700
Galα1–3Gal Xenoepitope: Donor-Targeted Genetic Strategies....Pages 701-713
Front Matter....Pages 715-715
Evolution: Its Complexity and Impact on Xenotransplantation....Pages 716-735
Xenotransplantation and Infectious Diseases....Pages 736-748
Nucleic Acid-Based Discovery Techniques for Potential Xenozoonotic Pathogens....Pages 749-765
Comments on Ethics in Human Xenotransplantation....Pages 766-773
Front Matter....Pages 775-775
Clinical Xenotransplantation - A Brief Review of the World Experience....Pages 776-784
Extracorporeal Xenogeneic Liver Perfusion for the Treatment of Hepatic Failure....Pages 785-792
Baboon Liver Xenotransplantation in Humans: Clinical Experience and Principles Learned....Pages 793-811
Clinical Islet Xenotransplantation - Transplantation of Porcine Islets into Diabetic Patients....Pages 812-820
Conceptual Scientific Development of the Xenotransplantation Project in Goteborg....Pages 821-831
Back Matter....Pages 833-854