Werner’s Syndrome and Human Aging

Front Matter....Pages i-xv
On Cataract in Conjunction with Scleroderma....Pages 1-14
Werner’s Syndrome (Progeria of the Adult) and Rothmund’s Syndrome: Two Types of Closely Related Heredofamilial Atrophic Dermatoses with Juvenile Cataracts and Endocrine Features; A Critical Study with Five New Cases....Pages 15-56
Werner’s Syndrome: A Review of its Symptomatology, Natural History, Pathologic Features, Genetics and Relationship to the Natural Aging Process....Pages 57-120
Werner Syndrome: A Review of Recent Research with an Analysis of Connective Tissue Metabolism, Growth Control of Cultured Cells, and Chromosomal Aberrations....Pages 121-160
Keynote Address: Genetics and Aging; The Werner Syndrome as a Segmental Progeroid Syndrome....Pages 161-170
Clinical, Endocrine and Metabolic Aspects of the Werner Syndrome Compared with Those of Normal Aging....Pages 171-185
Pathology of the Werner Syndrome....Pages 187-214
Neuropathology of the Werner Syndrome....Pages 215-218
Werner’s Syndrome and Aging: A Reappraisal....Pages 219-228
A Comparison of Adult and Childhood Progerias: Werner Syndrome and Hutchinson-Gilford Progeria Syndrome....Pages 229-244
Clinical, Demographic, and Genetic Aspects of the Werner Syndrome in Japan....Pages 245-261
Immunological Aspects of Werner’s Syndrome: An Analysis of 17 Patients....Pages 263-284
Clinical and Metabolic Studies on Werner’s Syndrome: With Special Reference to Disorders of Lipid and Liver Function....Pages 285-304
Growth Characteristics of Werner Syndrome Cells in Vitro....Pages 305-311
Studies of SV40-Infected Werner Syndrome Fibroblasts....Pages 313-330
Experimental Studies on Werner’s Syndrome Fibroblasts....Pages 331-339
Cell Fusion Studies in the Werner Syndrome....Pages 341-351
Cell Fusion Studies and Biochemical Analysis of DNA Synthesis in Werner and Non-Werner Cultured Cells....Pages 353-372
Histone H1 in G1 Arrested, Senescent, and Werner Syndrome Fibroblasts....Pages 373-389
Genome Reorganization During Aging of Dividing Cells....Pages 391-419
Cellular Mechanisms of Aging in the Werner Syndrome....Pages 421-438
Autoradiographic Studies of DNA Replication in Werner’s Syndrome Cells....Pages 439-457
Abnormal Fibroblast Aging and DNA Replication in the Werner Syndrome....Pages 459-477
Extrachromosomal Circular DNA and Aging Cells....Pages 479-493
Protein Synthetic Fidelity in Aging Human Fibroblasts....Pages 495-508
Analysis of Cellular Senescence through Detection and Assessment of RNAs and Proteins Important to Gene Expression: Transfer RNAs and Autoimmune Antigens....Pages 509-539
Cytogenetic Aspects of Werner Syndrome....Pages 541-546
A Population and Cytogenetic Study of the Werner Syndrome in Sardinia....Pages 547-552
Proteoglycans in the Werner Syndrome and Aging: A Review and Perspective....Pages 553-565
Cell Surface Changes in Senescent and Werner’s Syndrome Fibroblasts: Their Role in Cell Proliferation....Pages 567-585
Acidic Glycosaminoglycans in Werner’s Syndrome: Studies on Levels in Tissue, Organ, Cell, and Fluid....Pages 587-606
Acidic Glycosaminoglycans of SV40-Transformed Werner’s Syndrome Cells....Pages 607-612
Glycosaminoglycan Synthesis in Untransformed and Transformed Werner Syndrome Fibroblasts: A Preliminary Report....Pages 613-625
The Notion of Primordial Building Blocks in Construction of Genes and Transcriptional and Processing Errors Due to Random Occurrence of Oligonucleotide Signal Sequences....Pages 627-636
Appearance of Albumin-Producing Cells in the Liver of Analbuminemic Rats on Aging and Administration of Mutagens....Pages 637-650
Back Matter....Pages 651-656