Vitamin D Analogs in Cancer Prevention and Therapy

Front Matter....Pages I-VIII
Front Matter....Pages 1-1
Evolution and Function of Vitamin D....Pages 3-28
Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands....Pages 29-42
Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk....Pages 43-54
Ligand Structure—Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment)....Pages 55-82
Antiproliferative Signalling by 1, 25(OH) 2 D 3 in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation....Pages 83-98
Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells....Pages 99-110
Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH) 2 D 3 : Why?....Pages 111-122
A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis....Pages 123-134
Extrarenal Sites of Calcitriol Synthesis:The Particular Role of the Skin....Pages 135-145
Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1α-Hydroxylase....Pages 147-149
Gene Amplification and Splice Variants of 25-Hydroxyvitamin D 3 1, α-Hydroxylase (CYP27B1) in Glioblastoma Multiforme— A Possible Role in Tumor Progression?....Pages 151-155
Regulation of the 25-Hydroxyvitamin D-1α-Hydroxylase Gene and Its Splice Variant....Pages 157-167
Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism....Pages 169-188
Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs....Pages 189-202
Front Matter....Pages 203-203
The Role of Vitamin D in Prostate Cancer....Pages 205-221
Vitamin D Autocrine System and Prostate Cancer....Pages 223-237
Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer....Pages 239-246
Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor—Butyrate Connection....Pages 247-257
Analysis of the Vitamin D system in Cutaneous Malignancies....Pages 259-269
Front Matter....Pages 271-271
Evaluation of Vitamin D Analogs as Therapeutic Agents for Prostate Cancer....Pages 273-288
Front Matter....Pages 271-271
Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D 3 Analogs....Pages 289-317
Induction of Apoptosis by Vitamin D Metabolites and Analogs in a Glioma Cell Line....Pages 319-332
Vitamin D Analogs and Breast Cancer....Pages 333-348
A Low-Calcemic Vitamin D Analog (Ro 25-4020) Inhibits the Growth of LNCaP Human Prostate Cancer Cells with Increased Potency by Producing an Active 24-Oxo Metabolite (Ro 29-9970)....Pages 349-352
Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases....Pages 353-356
The Role of Reactive Oxygen Species in the Anticancer Activity of Vitamin D....Pages 357-367
Front Matter....Pages 369-369
Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates....Pages 371-377
Phytoestrogens and 17β-Estradiol Influence Vitamin D Metabolism and Receptor Expression—Relevance for Colon Cancer Prevention....Pages 379-391
Efficacy and Mechanism of Action of 1α-hydroxy-24-ethyl-Cholecalciferol (1α[OH]D5) in Breast Cancer Prevention and Therapy....Pages 393-411
Regulation of Extrarenal Vitamin D Metabolism as a Tool for Colon and Prostate Cancer Prevention....Pages 413-425
Modulation of X-ray-Induced Apoptosis in Human Keratinocytes (HaCaT) by 1,25-Dihydroxyvitamin D 3 ....Pages 427-432