Vasodilators in Chronic Heart Failure

Front Matter....Pages I-XV
Vasoconstrictor Mechanisms and the Effects of Nitrates....Pages 1-13
Functional and Metabolic Consequences of Chronic Alterations in Preload and Afterload in the Hypertrophied and Dilated Heart....Pages 14-29
The Sympathetic Nervous System in Chronic Heart Failure and Its Response to Vasodilator Therapy....Pages 30-35
Regulation of Renal Hemodynamics in Congestive Heart Failure....Pages 36-46
The Renin-Angiotensin-Aldosterone System in Congestive Heart Failure....Pages 47-57
Endogenous Catecholamines Under Chronic Vasodilator Treatment....Pages 58-67
Effects of Hydralazine and Isosorbide Dinitrate on Vasoconstrictor Mechanisms in Patients with Heart Failure....Pages 68-72
Cellular Mechanism of Action of Directly Acting Vasodilator Drugs....Pages 73-81
Pharmacokinetics of Nitrates....Pages 82-83
Isosorbide Dinitrate: Pharmacokinetics After Intravenous Administration....Pages 84-87
Prazosin and α-Blocking Agents....Pages 88-92
Promises and Disappointments of Vasodilator Treatment of Chronic Heart Failure....Pages 93-111
Nitrates in Chronic Heart Failure....Pages 112-123
The Long-Term Effects of Dihydralazine and Hydralazine on Intractable Cardiac Failure....Pages 124-130
The Use of Hydralazine for Chronic Cardiac Failure: Results and Unanswered Questions....Pages 131-138
Prazosin Therapy in Severe Chronic Congestive Heart Failure....Pages 139-146
Early Experience with Captopril in Congestive Heart Failure....Pages 147-153
Acute Effect of Nifedipine on Left Ventricular Performance at Rest and During Exercise in Patients with Left Ventricular Dysfunction....Pages 154-163
Treatment of Congestive Heart Failure with Dipyridamole....Pages 164-167
Therapeutic Agents with Combined Inotropic and Vasodilating Properties....Pages 168-175
Hemodynamic Effects of Combined Inotropic and Vasodilator Drugs in Severe Congestive Heart Failure: Hydralazine and Prenalterol....Pages 176-184
AR-L 115 BS, a Substance with Inotropic and Vasodilating Effects....Pages 185-203
Efficacy of AR-L 115 BS on Hemodynamics, Contractility, and Myocardial Oxygen Consumption in Man....Pages 204-209
Treatment of Cardiac Failure with AR-L 115 BS....Pages 210-214
Can Vasodilator Treatment Improve Life Expectancy and Physical Performance Heart Failure?....Pages 215-219
Vasodilators in Chronic Heart Failure: Problems of Design and Analysis of Controlled Clinical Trials....Pages 220-229
Back Matter....Pages 230-233