Vascular Endothelium: Physiological Basis of Clinical Problems

Front Matter....Pages i-x
Front Matter....Pages 1-1
The Clinical Profile of Sepsis and the Adult Respiratory Distress Syndrome....Pages 3-11
The Participation of the Complement System in Atherosclerotic Vascular Disease....Pages 13-26
The Spectrum of Atherosclerosis in the Human....Pages 27-45
Cerebral Endothelial Injury in Stroke, Brain Trauma and Hypertension....Pages 47-52
Front Matter....Pages 53-53
Free-Radical Mediated Actions on Endothelial Cells of the Intact Lung....Pages 55-67
Regulation of Vascular Function by Vascular Permeability Factor....Pages 69-76
Front Matter....Pages 77-77
Endothelial Cells as Targets for and Producers of Cytokines....Pages 79-85
Roles of Vascular Cells in Inflammation and Immunopathology....Pages 87-95
The Biochemistry, Cell and Molecular Biology of Type 1 Plasminogen Activator Inhibitor....Pages 97-107
Front Matter....Pages 109-109
Purine Regulation of Endothelial Cells: Relevance to Pathophysiology....Pages 111-116
Autoantibodies to Endothelial Cells....Pages 117-125
Leukocyte-Endothelial Cell Interactions....Pages 127-135
Front Matter....Pages 137-137
Endothelium Function in Human Coronary Bypass Grafts....Pages 139-155
Altered Renovascular Endothelial Functions During Nephrotoxicity....Pages 157-166
Cerebral Endothelial Function: Physiology and Pathophysiology....Pages 167-173
Mechanisms of Altered Reactivity in the Cerebral Microcirculation....Pages 175-180
Front Matter....Pages 181-181
The Role of Apolipoprotein E and Apolipoprotein B in Atherosclerosis....Pages 183-196
Endothelial Cell-Matrix Interactions in Health and Disease....Pages 197-202
Biosynthesis and Assembly of von Willebrand Factor by Vascular Endothelial Cells: Relevance to Pathophysiology....Pages 203-210
Front Matter....Pages 211-211
Monitoring of Endothelial Plasmalemmal Ectoenzyme Function as an Index of Endothelial Injury and Repair....Pages 213-223
Front Matter....Pages 211-211
Pathophysiological Significance of Endothelial Cell Integrins....Pages 225-229
Front Matter....Pages 231-231
Vascular Endothelium: Physiological Basis of Clinical Problems....Pages 233-237
Front Matter....Pages 239-239
Effects of Interleukin-1 α / β , Tumor Necrosis Factor- α and Interferon- γ on Human Endothelial Cell Permeability....Pages 241-242
Blood-Brain Barrier in Vitro : Pharmaceutical Applications....Pages 243-243
Neutrophils are Required for PMA-Induced Endothelial Ectoenzyme Dysfunction: Study in Cultured Endothelial Cells....Pages 244-244
Neutrophils are Required for PMA-Induced Endothelial Ectoenzyme Dysfunction: Study in Perfused Lung Preparation....Pages 245-245
Endothelial-Dependent Relaxations in Atherosclerotic Human Coronary Arteries....Pages 246-246
Use of in Vitro Autoradiography to Localize Binding Sites for Putative Endothelium-Derived Constrictor/Dilator Substances in Human Vascular Tissue....Pages 247-248
Angiogenin Acts as a Direct Mitogen on Bovine Brain Capillary Endothelial Cells....Pages 249-249
Platelet Function in Patients with Vasculitis Secondary to Behcet’s Disease....Pages 250-250
Resistance Vessel Endothelium: Isolation, Cloning and Characterization Studies....Pages 251-251
Biochemical Abnormalities of the Blood-Brain Barrier in Alzheimer’s Disease....Pages 252-252
Macrophage Activation in Bioresorbable Vascular Grafts....Pages 253-254
A Drug That Increases cGMP Blocks Thromboxane Induced Pulmonary Hypertension and Reduces Edema Formation in Oxidant Lung Injury....Pages 255-255
MAG-FURA-2 Elicited Fluorescent Response of Subcellular Magnesium in Endothelial Cells: A Sharp Contrast with Calcium....Pages 256-257
A Decrease in Plasminogen Activator Inhibitor-1 Activity after Successful PTCA is Associated with a Significantly Reduced Risk for Development of Coronary Restenosis....Pages 258-258
Endothelial Cell Hemostatic Function after Heart Transplantation....Pages 259-259
Response of Vascular Cells to Herpes Simplex Virus (HSV) Infection....Pages 260-261
Endothelial Cyclic Nucleotides are Unlikely to Regulate EDRF Release....Pages 262-263
The Human Lung as an Endothelin Clearance Organ: Normal Function and Derangement in Pulmonary Hypertension....Pages 264-264
Front Matter....Pages 239-239
Secretion of Endothelial-Leukocyte Adhesion Molecule (ELAM-1) Upon Deletion of Portions of Its Carboxyl Terminus....Pages 265-265
Basement Membrane Biosynthesis as a Target for Developing Inhibitors of Angiogenesis with Antitumor Activity....Pages 266-267
Modulation of Cyclic Nucleotide Accumulation in Cultured Vascular Cells....Pages 268-268
Polymorphonuclear Leukocytes (PMNL)-Endothelium Interaction in Vitro : Effects of Isolation Techniques of PMNL....Pages 269-270
Chemotaxins Inhibit Neutrophil Adhesion to and Transmigration of Cytokine-Activated Endothelium by a CD 11/18-Independent Mechanism....Pages 271-271
Combined Cytotoxic Effects of Bacterial Shiga Toxin, TNF, IL-1 and LPS on Vascular Endothelial Cells, in Vitro ....Pages 272-272
Application of an Opioid Affinity Label for Qualitative Analysis of Mu-Receptors....Pages 273-273
Pulmonary Endothelial Enzyme Function in Vivo , after Chest Irradiation....Pages 274-274
Endothelial Function of Vessels Used as Coronary Artery Bypass Grafts....Pages 275-275
Pathogenesis of Hemorrhage Induced by Rattlesnake Venoms and Their Purified Hemorrhagic Toxins....Pages 276-276
Antigenic Heterogeneity of Vascular Endothelium....Pages 277-278
Secretion of Monocyte Chemotactic Activity by Bleomycin Treated Rat Pulmonary Artery Endothelial Cells....Pages 279-279
Protein Kinase C Modulation of Serotonin Transport by Pulmonary Endothelial Cells....Pages 280-281
N-Hydroxylation and Vascular Relaxation: An Alternate EDRF Hypothesis....Pages 282-283
Investigation of ANF Receptor Function in Cultured Bovine Pulmonary Artery Endothelial Cells....Pages 284-285
Potentiation of Endothelin-1 Induced Pulmonary Vasoconstriction by Acidosis....Pages 286-286
The Effect of in Vivo and in Vitro Capsaicin Treatment on Endothelium Dependent Relaxation....Pages 287-287
Kawasaki Disease....Pages 288-288
Different Mechanisms of Homologous and Heterologous Desensitization of Thrombin Induced Endothelial Prostacyclin Production....Pages 289-289
Pro Oxidant Effects of Normobaric Hyperoxia in Rat Tissues....Pages 290-290
Front Matter....Pages 239-239
Comparative Study of Pathologic Cardiovascular Biomineralization....Pages 291-292
Inhibition of EDRF Synthesis Reduces the Pentagastrin-Induced Hyperaemia of the Rat Gastric Mucosa....Pages 293-293
Properties of a Reperfusible Model of Photochemically Induced Thrombotic Stroke in the Rat Middle Cerebral Artery Territory....Pages 294-295
Endothelial Cell Activation by Neutrophil Release Products....Pages 296-297
Blockade of CD18-Dependent Neutrophil Adhesion Limits Myocardial Infarct Size Following Coronary Artery Occlusion in Cynomolgus Monkeys....Pages 298-298
Influence of Hyperthermia on the Fibrinolytic Potential of Human Endothelial Cells....Pages 299-299
The Release of Vasoactive Mediators from Arterial and Venous Cultured Endothelial Cells....Pages 300-301
Back Matter....Pages 303-317