ویرایش:  
 
سری:  
ISBN (شابک) : 9781405185745, 9781118345313 
ناشر: Wiley-Blackwell 
سال نشر: 2012 
تعداد صفحات: 539 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 15 مگابایت 

قیمت کتاب (تومان) : 31,000

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

• Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
• Includes evaluation of vaccine efficacy and safety
• Details clinical trial design, including regulatory requirements
• Discusses the emerging field of active cellular immunotherapy

Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Content:
Chapter 1 Concept and Scope of Modern Vaccines (pages 1–11): D. Huw Davies, Clint S. Schmidt and Nadeem A. Sheikh
Chapter 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants (pages 13–28): Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel?van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter and Volker Gerdts
Chapter 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules (pages 29–46): Antony N. Antoniou, Izabela Lenart, David B. Guiliano and Simon J. Powis
Chapter 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design (pages 47–60): Janine Bilsborough and Joanne L. Viney
Chapter 5 Immunologic Memory: T Cells in Humans (pages 61–78): Maria Candela Iglesias, Victor Appay and Arnaud Moris
Chapter 6 Immunologic Memory: B cells (pages 79–93): F. Eun?Hyung Lee and Inaki Sanz
Chapter 7 Utility of Mouse Models in Vaccine Design and Development (pages 94–109): Catharine M. Bosio, Megan MacLeod, Philippa Marrack and Ross M. Kedl
Chapter 8 Utility of Nonhuman Primate Models for Vaccines (pages 110–130): Preston A. Marx and Alexander F. Voevodin
Chapter 9 Sequence?Based Computational Approaches to Vaccine Discovery and Design (pages 131–149): Darrick Carter
Chapter 10 Antigen Discovery for Vaccines Using High?Throughput Proteomic Screening Technologies (pages 150–167): D. Huw Davies
Chapter 11 Phage Libraries (pages 168–178): Aaron K. Sato
Chapter 12 Attenuated Bacterial Vaccines (pages 179–195): Richard W. Titball and Helen S. Atkins
Chapter 13 Virus?Like Particles as Antigen Scaffolds (pages 196–208): Bryce Chackerian and John T. Schiller
Chapter 14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development (pages 209–223): Yper Hall and Miles W. Carroll
Chapter 15 Recombinant Adenoviruses for Vaccination (pages 224–236): Nelson Cesar Di Paolo, Dmitry Shayakhmetov and Andre Lieber
Chapter 16 Recombinant Avipoxviruses (pages 237–254): Michael A. Skinner and Stephen M. Laidlaw
Chapter 17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy (pages 255–274): Patrick Guirnalda, Laurence Wood, Matthew Seavey and Yvonne Paterson
Chapter 18 Nucleic Acid Vaccination (pages 275–285): Britta Wahren and Margaret A. Liu
Chapter 19 Artificial Antigen?Presenting Cells: Large Multivalent Immunogens (pages 286–299): Matthew F. Mescher and Julie M. Curtsinger
Chapter 20 Transcutaneous Immunization via Vaccine Patch Delivery System (pages 301–323): Robert C. Seid and Gregory M. Glenn
Chapter 21 Needle?Free Jet Injection for Vaccine Administration (pages 324–335): Brian R. Sloat, Hoi K. Tran and Zhengrong Cui
Chapter 22 Oral Vaccines: An Old Need and Some New Possibilities (pages 336–347): Amit A. Lugade, Kalathil Suresh and Yasmin Thanavala
Chapter 23 Adjuvants: From Serendipity to Rational Discovery (pages 348–360): Derek T. O'Hagan and Andreas Wack
Chapter 24 Immunostimulatory Properties of Biodegradable Microparticles (pages 361–374): Fiona A. Sharp and Ed C. Lavelle
Chapter 25 Co?Administration of Co?Stimulatory Moieties (pages 375–392): Carolina Arancibia?Carcamo and Yvette Latchman
Chapter 26 Toll Receptors in Relation to Adjuvant Effects (pages 393–400): Dipshikha Chakravortty, Amit Lahiri and Priyanka Das
Chapter 27 Regulatory Issues (FDA and EMA) (pages 401–415): Murrium Ahmad, Victoria Byers and Peter Wilson
Chapter 28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine (pages 417–440): Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton and Camilla Jandus
Chapter 29 Clinical Development Strategy: Nuts and Bolts (pages 441–451): Candida Fratazzi and Claudio Carini
Chapter 30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification (pages 452–463): Robert Rees, Stephanie Laversin, Cliff Murray and Graham Ball
Chapter 31 Mass Immunization Strategies (pages 465–479): David L. Heymann, R. Bruce Aylward and Rudolf H. Tangermann
Chapter 32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making (pages 480–508): Marie?Claude Boily, Marc Brisson, Benoit Masse and Roy M. Anderson
Chapter 33 Vaccine Safety (pages 509–524): John Iskander, Claudia Vellozzi, Jane Gidudu and Robert T. Chen