Vaccine Design: The Subunit and Adjuvant Approach

Front Matter....Pages i-xlv
Immunological and Formulation Design Considerations for Subunit Vaccines....Pages 1-42
Public Health Implications of Emerging Vaccine Technologies....Pages 43-60
Preclinical Safety Assessment Considerations in Vaccine Development....Pages 61-79
Regulatory Considerations in Vaccine Design....Pages 81-96
Clinical Considerations in Vaccine Trials with Special Reference to Candidate HIV Vaccines....Pages 97-134
Laboratory Empiricism, Clinical Design, and Social Value....Pages 135-139
A Compendium of Vaccine Adjuvants and Excipients....Pages 141-228
Adjuvant Properties of Aluminum and Calcium Compounds....Pages 229-248
Structure and Properties of Aluminum-Containing Adjuvants....Pages 249-276
MF59 Design and Evaluation of a Safe and Potent Adjuvant for Human Vaccines....Pages 277-296
Development of Vaccines Based on Formulations Containing Nonionic Block Copolymers....Pages 297-311
Development of an Emulsion-Based Muramyl Dipeptide Adjuvant Formulation for Vaccines....Pages 313-324
Liposomal Presentation of Antigens for Human Vaccines....Pages 325-345
Liposome Design and Vaccine Development....Pages 347-361
Lipid Matrix-Based Vaccines for Mucosal and Systemic Immunization....Pages 363-387
Polymer Microspheres for Vaccine Delivery....Pages 389-412
Vehicles for Oral Immunization....Pages 413-438
Design and Production of Single-Immunization Vaccines Using Polylactide Polyglycolide Microsphere Systems....Pages 439-462
Nanoparticles as Adjuvants for Vaccines....Pages 463-472
Water-Soluble Phosphazene Polymers for Parenteral and Mucosal Vaccine Delivery....Pages 473-493
Monophosphoryl Lipid A as an Adjuvant....Pages 495-524
Structural and Immunological Characterization of the Vaccine Adjuvant QS-21....Pages 525-541
A Novel Generation of Viral Vaccines Based on the ISCOM Matrix....Pages 543-558
Vaccine Adjuvants Based on Gamma Inulin....Pages 559-580
A New Approach to Vaccine Adjuvants....Pages 581-609
Stearyl Tyrosine....Pages 611-624
Cytokines as Vaccine Adjuvants....Pages 625-643
Cytokines as Immunological Adjuvants....Pages 645-658
Cytokine-Containing Liposomes as Adjuvants for Subunit Vaccines....Pages 659-671
 Haemophilus influenzae Type b Conjugate Vaccines....Pages 673-694
Pneumococcal Conjugate Vaccines....Pages 695-718
Lyme Vaccine Enhancement....Pages 719-735
Vaccine Research and Development for the Prevention of Filarial Nematode Infections....Pages 737-768
Retrovirus and Retrotransposon Particles as Antigen Presentation and Delivery Systems....Pages 769-786
Rationale and Approaches to Constructing Preerythrocytic Malaria Vaccines....Pages 787-802
The MAP System....Pages 803-819
Design of Experimental Synthetic Peptide Immunogens for Prevention of HIV-1 and HTLV-I Retroviral Infections....Pages 821-845
Design and Testing of Peptide-Based Cytotoxic T-Cell-Mediated Immunotherapeutics to Treat Infectious Diseases and Cancer....Pages 847-874
Development of Active Specific Immunotherapeutic Agents Based on Cancer-Associated Mucins....Pages 875-890
Synthetic Peptide Vaccines for Schistosomiasis....Pages 891-905
Synthetic Hormone/Growth Factor Subunit Vaccine with Application to Antifertility and Cancer....Pages 907-930
Back Matter....Pages 931-949