Understanding Depression : Volume 1. Biomedical and Neurobiological Background

Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
 Highlights on Pharmacogenetics and Pharmacogenomics in Depression  (Chiara Fabbri, Alessandro Serretti)....Pages 3-16
 Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future  (Eunsoo Won, Byung Joo Ham, Yong-Ku Kim)....Pages 17-39
 Gene-Environment Interactions and Role of Epigenetics in Depression  (Eugene Lin, Shih-Jen Tsai)....Pages 41-50
 miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder  (Bhaskar Roy, Yogesh Dwivedi)....Pages 51-69
 The Role of Early Life Stress in HPA Axis and Depression  (Mario F. Juruena, Anthony J. Cleare, Allan H. Young)....Pages 71-80
Front Matter ....Pages 81-81
 Complex Role of the Serotonin Receptors in Depression: Implications for Treatment  (Meysam Amidfar, Lejla Colic, Martin Walter, Yong-Ku Kim)....Pages 83-95
 Emerging Role of Glutamate Receptors in Pathophysiology of Depression  (Kyoung-Sae Na, Yong-Ku Kim)....Pages 97-105
 New Perspective on mTOR Pathways: A New Target of Depression  (Gislaine Z. Réus, Zuleide M. Ignácio, Helena M. Abelaira, João Quevedo)....Pages 107-114
 Biological Markers to Differentiate the Subtypes of Depression  (Je-Yeon Yun, Seung-Hwan Lee)....Pages 115-128
Front Matter ....Pages 129-129
 Structural, Functional, and Molecular Neuroimaging in Depression  (Kai Zhang, Jing Huang, Jin Feng, Hong Zhang, Mei Tian)....Pages 131-143
 Why Do We Need Psychopathology? From the Brain’s Resting State to “Spatiotemporal Psychopathology” of Depression  (Georg Northoff)....Pages 145-152
 Neuroimaging in Depression: A Tool Toward Individualized Prediction of Treatment Outcome  (Boudewijn J. H. B. de Pont, Jeroen A. Van Waarde, Guido A. van Wingen)....Pages 153-160
 Cortical–Subcortical Interactions in the Pathophysiology of Depression  (Kang Soo Lee, Sang Hyuk Lee)....Pages 161-165
 Pathophysiology and Treatment Strategies for Different Types of Depression  (Hwa-Young Lee, Yong-Ku Kim)....Pages 167-176
 The Effect of Neurostimulation in Depression  (Rafael C. R. Freire, Antonio E. Nardi)....Pages 177-187
Front Matter ....Pages 189-189
 Chronic Inflammation and Resulting Neuroprogression in Major Depression  (Brian E. Leonard)....Pages 191-196
 Gut-Microbiota-Brain Axis and Depression  (Alper Evrensel, Mehmet Emin Ceylan)....Pages 197-207
 Modulating Microglial Activation As a Possible Therapeutic Target for Depression  (Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji et al.)....Pages 209-219
 Experimental Animal Models for Depressive Disorders: Relevance to Drug Discovery  (Boldizsár Czéh, Ove Wiborg, Eberhard Fuchs)....Pages 221-231
 The Use of Animal Models in Defining Antidepressant Response: A Translational Approach  (Michel Bourin)....Pages 233-242
Front Matter ....Pages 243-243
 Precision Psychiatry: Personalized Clinical Approach to Depression  (Giampaolo Perna, Raffaele Balletta, Charles B. Nemeroff)....Pages 245-261
 Risk Factors and Prevention Strategies for Depression in Childhood and Adolescence  (Jun Won Kim, Jae-Won Kim)....Pages 263-278
 Neurobiology and Risk Factors of Late-Life Depression  (Neha Jain, David C. Steffens)....Pages 279-295
 Gender Differences in Depression  (Seoyoung Yoon, Yong-Ku Kim)....Pages 297-307
 An Update on the Epidemiology of Major Depressive Disorder Across Cultures  (Joao P. De Aquino, Alicia Londono, André F. Carvalho)....Pages 309-315
Back Matter ....Pages 317-322