Ubiquitin

Front Matter....Pages i-xviii
Introduction....Pages 1-4
Purification and Structural Properties of Ubiquitin....Pages 5-38
Molecular Genetics of the Ubiquitin System....Pages 39-75
Ubiquitin Activation and Ligation....Pages 77-99
Ubiquitin/ATP-Dependent Protease....Pages 101-134
Ubiquitin Carboxyl-Terminal Hydrolases....Pages 135-155
Ubiquitinated Histones and Chromatin....Pages 157-172
Immunochemical Probes of Ubiquitin Pool Dynamics....Pages 173-206
Protein Breakdown and the Heat-Shock Response....Pages 207-238
Lymphocyte Homing Receptors, Ubiquitin, and Cell Surface Proteins....Pages 239-269
Role of Transfer RNA in the Degradation of Selective Substrates of the Ubiquitin- and ATP-Dependent Proteolytic System....Pages 271-286
The N-End Rule of Selective Protein Turnover....Pages 287-324
Selectivity of Ubiquitin-Mediated Protein Breakdown....Pages 325-332
Back Matter....Pages 333-346