Tumor Budding In Colorectal Cancer: Recent Progress In Colorectal Cancer Research

HORIZONS IN CANCER RESEARCH......Page 4
TUMOR BUDDING IN COLORECTAL CANCER: RECENT PROGRESS IN COLORECTAL CANCER RESEARCH......Page 5
NOTICE TO THE READER......Page 6
CONTENTS......Page 7
FOREWORD......Page 9
PREFACE......Page 11
PART 1: HISTORICAL ASPECTS OF TUMOR BUDDING......Page 13
Introduction......Page 15
Material and Methods......Page 17
Results......Page 19
Materials and Methods......Page 20
Results......Page 22
References......Page 23
Acknowledgements......Page 25
Introduction......Page 27
Histological Evaluation of the Invasive Front in Japan......Page 28
The Mechanism of Tumor Budding......Page 29
Clinical Significance of Tumor Budding in T1 (early invasive) Colorectal Cancer......Page 30
Clinical Significance of Tumor Budding in Advanced Colorectal Cancer......Page 32
A Trial of Preoperative Detection of Tumor Budding by Preoperative Biopsy......Page 34
References......Page 35
PART 2: BASIC RESEARCH......Page 39
Introduction......Page 41
K-ras......Page 42
p53......Page 43
APC......Page 44
MSI......Page 45
DPC4......Page 46
Colorectal Tumorigenesis in Mouse Model......Page 47
Abrogated Wnt/wingless Signaling in Colorectal Carcinogenesis......Page 48
The Function of Target Genes in Tumorigenesis......Page 49
Altered Gene Expression in Adenomas and Carcinomas of the Colon......Page 50
Conclusion......Page 52
References......Page 53
Introduction......Page 61
The E-cadherin/catenin Complex......Page 62
The Wnt/wingless Pathway......Page 63
Expression of β-catenin in Colorectal Carcinomas......Page 66
Effects of β-catenin in Carcinoma Cells......Page 69
β-catenin and Tumor Cell Budding......Page 70
Summary......Page 74
References......Page 75
PART 3: PATHOLOGICAL SESSION......Page 83
Introduction......Page 85
Budding – A Dynamic Process under Genetic Control......Page 86
Budding and the WNT Signaling Pathway......Page 88
APC Mutation, DNA Microsatellite Instability and Budding......Page 89
E-cadherin, Fibronectin and Budding......Page 90
Proliferation Markers and Budding......Page 91
References......Page 93
Introduction......Page 97
Histologic Diagnosis......Page 98
Morphopathobiological Definition of Tumor Budding......Page 99
Chi-squared Test and Multivariate Logistic Regression Analysis Applied to Budding......Page 103
Lymphatic Permeation......Page 105
Transition of the Growing Bud as Seen in the Serial Thin Sections......Page 106
Serial Thin Sections of the Budding Region......Page 107
Budding as Seen in an Interesting Creature: “Polyandrocarpa Misakiensis”......Page 108
Discussion......Page 109
References......Page 113
Introduction......Page 117
Patients and Methods......Page 118
Method of Determining Budding (Microtubular Cancer Clusters or Undifferentiated Cancer Cells)......Page 119
Results......Page 120
Discussion......Page 124
References......Page 126
Acknowledgements......Page 128
Introduction......Page 129
Cohort Migration and Tumor Budding......Page 130
In vitro Cohort Migration Model......Page 131
The E-cadherin/catenin System......Page 132
IQGAP1......Page 133
IQGAP1 in Cohort Migration......Page 134
Involvement of IQGAP1 in Cross-talk between Signals Induced by Motogenic Factors and Cell-extracellular Matrix (ECM) Interactions......Page 137
IQGAP1 Expression and Carcinomas......Page 139
Front Cell-specific Expression of MT1-MMP and Gel A during Cohort Migration......Page 140
MMP-Dependent Reorganization of ECM and Exposure of Putative Cryptic Promigratory Sites within ECM Proteins, including Laminin-5 γ2 Chain......Page 141
References......Page 143
PART 4: CLINICAL RESEARCH......Page 149
Introduction......Page 151
Malignant Potential of Submucosally Invasive Carcinomas......Page 152
Tumor Budding at the Invasive Margin......Page 154
Evaluation of Tumor Budding......Page 155
Decision Analysis......Page 156
References......Page 160
Introduction......Page 163
Value of Tumor Budding as a Prognosticator......Page 167
Clinical Implication of Tumor Budding in Biopsy Specimens......Page 172
Assessment of the Extent of Extramural Spread......Page 173
Assessment of the Possibility of Intramural Distal Spread (IM)......Page 176
References......Page 178
Introduction......Page 183
Criteria for EMR Radical Cure of Colorectal Sm Carcinoma Based on Conventional Histopathologic Findings in HE Sections......Page 184
Molecular Organization in Colorectal Carcinoma Infiltration and Metastasis......Page 185
Prediction of Lymph Node Metastasis by Means of Molecular Pathologic Markers......Page 186
Prediction of Lymph Node Metastasis by Combining Several Molecular Pathologic Markers......Page 188
Conclusion......Page 190
References......Page 191
INDEX......Page 193