Triazenes: Chemical, Biological, and Clinical Aspects

Front Matter....Pages i-viii
Triazenes: Synthesis and Chemical Properties....Pages 1-13
Mechanisms of the Biological Actions of Triazenes....Pages 15-22
Triazenes and Triazene N-Oxides: Antitumour Action in Animal Tumour Systems....Pages 23-43
Antimestastatic Action of Triazene Derivatives....Pages 45-62
Effects of Triazenes on Immune Responses....Pages 63-77
Xenogenization of Experimental Tumors by Triazene Derivatives....Pages 79-89
The Metabolism of Antineoplastic Triazenes....Pages 91-96
Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity....Pages 97-107
Clinical Use of Triazenes....Pages 109-118
Clinical Studies with the p-Carboxyl Dimethyl Phenyl Triazene CB10-277....Pages 119-131
Triazenes: Therapeutic Considerations and Perspectives....Pages 133-144
Antitumour Imidazotetrazinones: Prodrugs Targeted to the Major Groove of DNA....Pages 145-159
O 6 -Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes....Pages 161-172
N-Methylmelamines, a Unique Class of Anti-Tumour Agents?....Pages 173-184
Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives....Pages 185-193
O 6 -Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumour and Normal Tissue Levels....Pages 195-206
Summary of Poster-Sessions....Pages 207-211
Back Matter....Pages 213-227