Trends in Gastroenterology and Hepatology

Front Matter....Pages II-XVII
Front Matter....Pages 1-1
Reflecting Forward: Gastroenterology in the New Millennium....Pages 3-12
Front Matter....Pages 13-13
Pathophysiology of and New Treatment for Ulcerative Colitis....Pages 15-24
Front Matter....Pages 25-25
New Target of Gastroenterology: Overcoming Life Style-Related Diseases....Pages 27-32
Front Matter....Pages 33-33
Examination of Cytotoxic T Lymphocyte-Mediated Apoptosis Pathway in Peptic Ulcer Formation with or without H. pylori Infection....Pages 35-42
Epidermal Growth Factor Inhibits Helicobacter pylori Lipopolysaccharide-Induced Apoptosis of Primary Cultures of Gastric Pit Cells....Pages 43-46
Impaired Sensitivity to Fas-Induced Apoptosis of Lymphocytes in Ulcerative Colitis Lesions....Pages 47-52
Tumor Necrosis Factor α-Induced Hepatic Apoptosis and Hepatocyte Sensitization....Pages 53-58
Molecular Mechanisms of D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice and the Effects of Therapeutic Agents....Pages 59-62
Ethanol-lnduced Apoptosis Mediated by Mitochondrial Permeability Transition in Primary Cultured Sinusoidal Endothelial Cells....Pages 63-65
Therapeutic Strategies for Hepatocellular Carcinoma Based on Analyses for Resistance to Apoptosis Mediated by Activation of Intracellular Signal Pathways....Pages 66-70
Expression of Apoptosis-Related Factors in Human Pancreatic Duct Cell Carcinoma and Intraductal Papillary-Mucinous Tumor....Pages 71-75
Front Matter....Pages 77-77
Effect of Exogenous and Endogenous Nitric Oxide on Endothelial Permeability Induced by Oxidants In Vitro....Pages 79-81
Gastric Carcinoma and Helicobacter pylori Infection: Role of Nitric Oxide and Inflammatory Cytokines in Gastric Carcinogenesis....Pages 82-85
Does Cyclooxygenase-2 Down-Regulate Gastric Inflammation?....Pages 86-89
Regulation of Mucin Synthesis by Neuronal Nitric Oxide Synthase in Gastric Pit Cells....Pages 90-94
Role of Nitric Oxide and Capsaicin-Sensitive Sensory Nerves in Gastric Receptive Relaxation and Adaptive Relaxation in Isolated Stomachs of Guinea Pigs....Pages 95-98
Role of Inducible Nitric Oxide Synthase in Murine Colitis....Pages 99-102
Role of Nitric Oxide in the Progression of Severe Acute Pancreatitis....Pages 103-105
Role of Nitric Oxide in the Progression of Acute Pancreatitis....Pages 106-111
Protective Effect of Nitric Oxide on Acute Liver Failure in Rats....Pages 112-114
Front Matter....Pages 77-77
Regulatory Mechanism of Cationic Amino Acid Transporters in Hepatic Sinusoidal Ito Cells....Pages 115-119
Front Matter....Pages 121-121
Novel NADPH Oxidase, Mox1, Expressed in Cultured Gastric Pit Cells: Modulation of NF-κB Activation....Pages 123-127
Role of PPARγ in the Growth and Differentiation of Gastric and Colorectal Cancers....Pages 128-131
PPARγ Ligand and Induction of Growth Arrest in Pancreatic Cancer Cells....Pages 132-137
Role of β-Catenin During Early Colorectal and Hepatic Carcinogenesis....Pages 138-141
Growth Inhibition of Hepatoma Cells by Type 1 Interferons: Modification by Mutations in the Interferon Regulatory Factor-1 Gene....Pages 142-146
Growth Inhibition of Pancreatic Cancer Cell Lines by Ligand Activation of Nuclear Hormone Receptors Through Up-Expression of WAF1/CIP1/p21....Pages 147-152
Front Matter....Pages 153-153
Immunopathological Features of Granuloma Formation in the Intestinal Mucosa of Patients with Crohn’s Disease....Pages 155-159
 Helicobacter pylori and N -Methyl- N ’-nitro- N -nitrosoguanidine Induction of Dendritic Cell Infiltration of the Pyloric Mucosa of Mongolian Gerbils....Pages 160-166
Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells....Pages 167-170
Autoimmune Mechanisms of Cancer-Associated Paraneoplastic Syndromes: A Review....Pages 171-174
Antitumor Activity Against Gastrointestinal and Hepatocellular Carcinoma Induced by Immunization with Fusion of Dendritic and Carcinoma Cells in Mice....Pages 175-179
Front Matter....Pages 181-181
Essential Role for lnterleukin-6 in the Pathogenesis of Crohn’s Disease....Pages 183-186
Activation of Nuclear Factor κB in Dextran Sulfate Sodium-Induced Colitis in Mice and Their Inhibition by Phenyl N-tert -Butylnitrone....Pages 187-192
Essential Roles for Th2-Type Responses in Chronic Intestinal Inflammation....Pages 193-196
Induction of Colitis and Exocrinopathy in Nude Mice Induced by Immunocompetent Cell Transfer from Murine Retrovirus-lnfected Mice....Pages 197-200
Potential Role of Mucosal Addressin Cell Adhesion Molecule-1 in Inflammatory Bowel Diseases....Pages 201-204
Anti- Saccharmomyces cerevisiae Antibody in Inflammatory Bowel Disease....Pages 205-207
Reactive Oxygen Species and Colonic Epithelial Cell Apoptosis in Ulcerative Colitis....Pages 208-212
Front Matter....Pages 213-213
Effect of Antiulcer Drugs for Treatment of Nonsteroidal Antiinflammatory Drug-Induced Ulcers....Pages 215-218
Front Matter....Pages 213-213
Role of Intravascular Neutrophils in the Pathogenesis of Aspirin-Induced Gastric Mucosal Injury....Pages 219-223
Mucin Secretion Evoked by Prostaglandin E 2 in Guinea Pig Antral Mucous Cells: Role of EP1/EP4 Receptors....Pages 224-228
Effects of Indomethacin and NS-398 on Acid-Induced E-Cadherin Surface Expression in Rat Gastric Epithelial Cells....Pages 229-232
Roles of Reactive Nitrogen Species in Helicobacter -Related Carcinogenesis....Pages 233-236
Interaction Between Helicobacter pylori Infection and NSAID Use....Pages 237-241
Interrelations of Nonsteroidal Antiinflammatory Drugs, H. pylori Infection, and Gastric Damage....Pages 242-245
Front Matter....Pages 247-247
Microvascular Leukocyte Activation and Apoptosis in Helicobacter pylori -Colonized Gastric Mucosa....Pages 249-256
Alteration of Gastric Microcirculatory Architecture During Healing of Acetic Acid-Induced Ulcer and Helicobacter pylori Infection....Pages 257-262
Cyclooxygenase and Colon Cancer....Pages 263-266
Contribution of Colon Cancer Cells to Mesenchymal Cells in the Formation of Hepatic Metastasis....Pages 267-271
Hepatic Microcirculation in Massive Liver Necrosis and Liver Regeneration....Pages 272-276
Prevention of Hepatic Ischemia/Reperfusion Injury by Microcirculatory Regulation: Application to Liver Transplantation....Pages 277-282
Genetic Manipulation of Sinusoidal Endothelial Cells....Pages 283-286
Controlling Tumor Microenvironment by the Antiangiogenesis Strategy....Pages 287-289
Pancreatic Blood Flow in Chronic Alcoholic Pancreatitis....Pages 290-293
Front Matter....Pages 295-295
The Role of Hepatic Oval Cells in Hepatic Regeneration: Possible Clinical Applications....Pages 297-301
Hepatoma-Derived Growth Factor: Involvement in Liver Development and Regeneration....Pages 302-305
Tumor Necrosis Factor and Liver Regeneration....Pages 306-311
Heparin-Binding EGF-Like Growth Factor: Hepatotrophic Factor in Liver Regeneration....Pages 312-316
Effects of Growth Stimulatory and Inhibitory Factors on Signal Transduction of Cultured Rat Hepatocyte and the Regulation of Cyclin D1 Transcription....Pages 317-320
Front Matter....Pages 295-295
Significance of the Relation Between Hepatocyte Growth Factor and Transforming Growth Factor-α in Hepatocyte Proliferation....Pages 321-324
Front Matter....Pages 325-325
Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-ß and Smad Proteins....Pages 327-330
Clinical Usefulness of Plasma MMP-9 Assay Compared with the Plasma MMP-2 Assay in Patients with Chronic Liver Disease....Pages 331-335
Molecular Mechanisms of Matrix Metalloproteinase-1 Gene Expression in Hepatic Stellate Cells....Pages 336-339
Molecular Analysis of Stellate Cells Activation by Proteomics....Pages 340-343
Tissue Inhibitor of Metalloproteinase-1: Strong Promotion of Liver Fibrosis Development in the Transgenic Mouse Model....Pages 344-349
Antioxidant and Antiapoptotic Activities of a Tissue-Specific Selective Estrogen Receptor Modulator, Idoxifene, in Rat Fibrotic Liver and Cultured Rat Hepatocytes....Pages 350-355
Blockade of TGFβ Signaling: Prevention of Fibrosis/Dysfunction and Enhancement of Hepatocyte Regeneration in Injured Liver....Pages 356-360
Protease Inhibitors: Suppression of Activation of Hepatic Stellate Cells by Inhibiting TGFβ Generation....Pages 361-363
Plasma Transforming Growth Factor-β1: A Useful Marker for Hepatic Fibrosis in Chronic Hepatitis C....Pages 364-366
Back Matter....Pages 367-370