Trends in Drug Research III

Content: 
Preface
Page ix
H. Timmerman

Towards rational design of AMPA receptor ligands: An integrated medicinal, computational, biostructural and molecular pharmacological approach Original Research Article
Pages 1-12
Anders Hogner, Jette S. Kastrup, Jeremy Greenwood, Stine B. Vogensen, Eva H. Møller, Tine B. Stensbøl, Jan Egebjerg, Povl Krogsgaard-Larsen

From heparin to synthetic antithrombotics: The pentasaccharide story and follow-up Original Research Article
Pages 13-19
C.A.A. van Boeckel

A new future for synthesis? Original Research Article
Pages 21-26
Alle Bruggink

Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals Original Research Article
Pages 27-37
Manfred T. Reetz

At the interface of organic synthesis and biosynthesis Original Research Article
Pages 39-51
Rob Schoevaart, Tom Kieboom

What can structure tell us about function in the estrogen receptors? Original Research Article
Pages 53-56
Roderick E. Hubbard

Molecular docking and dynamics simulations in the ligand binding domain of steroid hormone receptors Original Research Article
Pages 57-66
Milou Kouwijzer, Jordi Mestres

Peroxisome proliferator-activated receptors and reverse endocrinology Original Research Article
Pages 67-79
Steven Kliewer, Glaxo Smith Kline

Biomolecular mass spectrometry related to drug research Original Research Article
Pages 81-94
Albert J.R. Heck, Claudia S. Maier

Chemical and biological diversity in drug discovery
Pages 95-96
P. Angeli, G. Gaviraghi

Muscarinic acetylcholine receptor knockout mice: Phenotypical analysis and clinical implications Original Research Article
Pages 97-113
J. Gomeza, M. Yamada, A. Duttaroy, W. Zhang, R. Makita, T. Miyakawa, J. Crawley, L. Zhang, H. Shannon, F.P. Bymaster, C.C. Felder, C. Deng, J. Wess

Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful peripheral neuropathies Original Research Article
Pages 115-124
P.F. Zaratin, A. Quattrini, S. Previtali, G. Hervieu, M.A. Scheideler

Computational methods for the analysis of molecular diversity Original Research Article
Pages 125-133
Valerie J. Gillet, Peter Willett

Enhancing drug discovery by acquisition of chemical diversity Original Research Article
Pages 135-146
David Langley

Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization Original Research Article
Pages 147-160
Pierfausto Seneci

Beyond G proteins: The role of accessory proteins in G protein-coupled receptor signalling Original Research Article
Pages 161-173
Herwig Just, Eduard Stefan, Cornelia Czupalla, Bernd Nürnberg, Christian Nanoff, Michael Freissmuth

Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D2 dopamine receptor Original Research Article
Pages 175-180
Philip G. Strange

Agonist channeling of α2-adrenoceptor function Original Research Article
Pages 181-192
Karl E.O. Åkerman, Johnny Näsman, Tomas Holmqvist, Jyrki P. Kukkonen

Antibacterials as wonder drugs and how their effectiveness is being compromised Original Research Article
Pages 193-205
Dasantila Golemi, Laurent Maveyraud, Jalal Haddad, Wenlin Lee, Akihiro Ishiwata, Kazuyuki Miyashita, Lionel Mourey, Sergei Vakulenko, Lakshmi Kotra, Jean-Pierre Samama, Shahriar Mobashery

Pseudomonas aeruginosa quorum sensing: A target for antipa thogenic drug discovery Original Research Article
Pages 207-212
Everett P. Greenberg

Discovery and development of new anti-bacterial drugs Original Research Article
Pages 213-225
Ian Chopra, Lars Hesse, Alexander O'Neill

Discovery of small molecule insulin mimetics as potential novel antidiabetic agents Original Research Article
Pages 227-236
Bei B. Zhang

Expression databases for pharmaceutical lead optimisation Original Research Article
Pages 237-247
L. Mike Furness

New developments in the pharmacology of cannabinoids Original Research Article
Pages 249-258
Roger G. Pertwee

Author index
Page 259

Subject index
Pages 261-262