Treatment of acute leukemias : new directions for clinical research

Team DDU......Page 1
Preface......Page 6
CONTENTS......Page 10
Contributors......Page 14
PART I: DIAGNOSIS, CLASSIFICATION, AND PROGNOSIS......Page 18
1 Classification of Acute Leukemias: Perspective 1......Page 20
2 Classification of Acute Leukemias: Perspective 2......Page 60
A. Infant Leukemias......Page 76
3 Biology and Treatment of Infant Leukemias: Perspective 1......Page 78
4 Biology and Treatment of Acute Leukemias in Infants: Perspective 2......Page 92
B. Childhood Acute Lymphoblastic Leukemia......Page 102
5 Treatment of Childhood Acute Lymphoblastic Leukemia......Page 104
6 Treatment of Childhood Acute Lymphoblastic Leukemia:The Dana-Farber Cancer Institute ALL Consortium Perspective......Page 122
C. Acute Lymphoblastic Leukemia in Adolescents and Young Adults......Page 128
7 Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults:Lessons Learned and Future Directions......Page 130
8 Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia:Children\'s Cancer Group Trials......Page 138
D. Acute Lymphoblastic Leukemia in Adults......Page 146
9 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1......Page 148
10 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2......Page 160
E. Central Nervous System Therapy for Acute Lymphoblastic Leukemia......Page 176
11 Central Nervous System–Directed Therapy for Acute Lymphoblastic Leukemia......Page 178
12 Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia......Page 190
F. Relapsed Acute Lymphoblastic Leukemia......Page 198
13 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1......Page 200
14 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2......Page 216
15 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1......Page 240
16 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2......Page 246
H. Acute Myeloid Leukemia in Children......Page 252
17 Treatment of Acute Myeloid Leukemia in Children......Page 254
18 Treatment of Childhood Acute Myeloid Leukemia......Page 272
I. Acute Myeloid Leukemia in Adults......Page 284
19 Therapy of Acute Myeloid Leukemia in Adults......Page 286
20 Treatment of Adult Acute Myelogenous Leukemia......Page 296
J. Acute Promyelocytic Leukemia......Page 306
21 Acute Promyelocytic Leukemia: Perspective 1......Page 308
22 Acute Promyelocytic Leukemia: Perspective 2......Page 326
23 Treatment of Childhood Leukemias in Underprivileged Countries......Page 338
24 How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations......Page 348
A. High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia......Page 354
25 Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia......Page 356
26 Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia......Page 374
B. Asparaginase......Page 380
27 Asparaginase......Page 382
28 Asparaginase Treatment......Page 398
C. Antipurines in Childhood Acute Lymphoblastic Leukemia......Page 410
29 Antipurines in Childhood Acute Lymphoblastic Leukemia......Page 412
30 Antipurines......Page 422
D. Epipodophyllotoxins......Page 436
31 Etoposide in Acute Leukemias: Therapeutic and Pharmacokinetic Considerations......Page 438
32 Etoposide and Teniposide: Clinical Applications with a Focus on Leukemia......Page 446
PART IV: HEMATOPOIETIC STEM CELL TRANSPLANTATION......Page 456
33 Hematopoietic Stem Cell Transplantation: Perspective 1......Page 458
34 Hematopoietic Stem Cell Transplantation: Perspective 2......Page 466
A. Hematopoietic Growth Factors......Page 474
35 Hematopoietic Growth Factors in Patients with Acute Leukemia......Page 476
36 Hematopoietic Growth Factor Treatment in Leukemia......Page 482
B. Immunotherapy......Page 490
37 Immunotherapy of Leukemia......Page 492
38 Therapy of Acute Leukemia with Monoclonal Antibodies and Immunoconjugates......Page 502
PART VI: DRUG RESISTANCE......Page 512
39 Drug Resistance in Acute Leukemias......Page 514
40 Drug Resistance in Acute Leukemia......Page 524
PART VII: MINIMAL RESIDUAL DISEASE......Page 542
41 Minimal Residual Disease......Page 544
42 Molecular Monitoring of Minimal Residual Disease......Page 554
Index......Page 566