Transforming Growth Factor-β in Cancer Therapy, Volume I: Basic and Clinical Biology

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Component Hardware for Transforming Growth Factor-β Signal Transduction: TGF-β Ligands, TGF-β Receptors, and Smads....Pages 3-21
TGF-β Signaling in Homeostasis and Cancer....Pages 23-35
TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins....Pages 37-55
Biological Functions of Latent TGF-β-Binding Proteins and Activation of TGF-β....Pages 57-75
Regulators of Smad2/3 Transcription and Phosphorylation....Pages 77-90
Interaction of Smad4 and Embryonic Liver Fodrin-β-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression....Pages 91-103
Regulation of Smad Activity by Phosphorylation....Pages 105-123
Nuclear Targeting of TGF-β-Activated Smads in Normal and Tumor Biology....Pages 125-136
Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival....Pages 139-153
Transforming Growth Factor-β in Cancer Therapy: Smurfs in TGF-β Signaling and Regulation of Bone Homeostasis and Cancer....Pages 155-167
Involvement of km23 Dynein Light Chains in TGF β Signaling....Pages 169-184
TGF-β Signaling in Fibroblastic Cells and Oncogenesis....Pages 185-198
Mechanisms of TGF-β-Induced Apoptosis in Cancer Cells....Pages 199-211
Mechanisms of Cell Cycle Regulation by TGF-β Disabled in Cancer....Pages 213-242
Transforming Growth Factor-β in Cancer Therapy....Pages 243-257
TGF-β and Smad Signaling in Transcriptome Reprogramming During EMT....Pages 259-273
Functional Interactions Between MMPs and TGF-β in Normal and Tumor Tissue....Pages 275-292
Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function....Pages 293-303
Interaction of Oncogenic Ras and TGFβ1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model....Pages 305-315
Front Matter....Pages 317-317
Proteomics Analysis of TGFβ Superfamily Members....Pages 319-331
Front Matter....Pages 317-317
Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers....Pages 333-353
Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression....Pages 355-372
Bone Morphogenic Proteins and Angiogenesis in Developing Tumors....Pages 373-381
Histone Methyltransferase and Smad Interactions in BMP Signaling....Pages 383-393
Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies....Pages 395-410
Activins and Inhibins in Cancer Progression....Pages 411-423
Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma....Pages 425-450
Regulation of the Transforming Growth Factor-β Superfamily by Betaglycan....Pages 451-461
Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney....Pages 463-473
Role of Betaig-h3 Gene in Carcinogenesis....Pages 475-482
Activins and the Liver....Pages 483-508
Myostatin Signaling in Normal and Tumor Cells....Pages 509-522
Front Matter....Pages 523-523
Triterpenoids, Vitamin D, and TGF-β/Smad Signaling in Inflammation and Cancer....Pages 525-547
Thrombospondin-Dependent Activation of Latent TGF-β in Fibrosis and Disease....Pages 549-567
TGF-β in Pulmonary Fibrosis....Pages 569-580
The Role of TGF-β in Bleomycin Induced Pulmonary Fibrosis....Pages 581-594
Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse....Pages 595-607
TGF-β Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7....Pages 609-619
Transforming Growth Factor-β Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema....Pages 621-628
The Role of TGF-β in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-β as a Novel Therapeutic Strategy....Pages 629-647
Front Matter....Pages 523-523
Negative Regulation of the TGF-β Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis....Pages 649-661
TGF-β-Related Antifibrotic Strategies in the Eye....Pages 663-673
Transforming Growth Factor-β in Cutaneous Tissue Repair....Pages 675-691
Topical Application of TGF-β1 Peptide Inhibitors for the Therapy of Skin Fibrosis....Pages 693-702
Overexpressed Truncated TGF-β Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo....Pages 703-721
Back Matter....Pages 723-735