Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Cancer Drug Discovery and Development)

Front Matter....Pages i-xxvi
Front Matter....Pages 1-1
Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease....Pages 3-19
Role of Transforming Growth Factor-β in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma....Pages 21-32
TGF-β, Smads and Cervical Cancer....Pages 33-49
TGF-β Signaling and Biglycan in Pancreatic Cancer....Pages 51-62
TGF-β Signaling in Endometrial Cancer....Pages 63-78
TGF-β Ligands, TGF-β Receptors, and Lung Cancer....Pages 79-93
Role of TGF-β in Osteolytic Bone Metastases....Pages 95-123
Hormonal Regulation of Transforming Growth Factor-β in Breast Cancer....Pages 125-132
TGF-β and Progression of Esophageal Cancer....Pages 133-140
TGF-β and HER2/ErbB2 and Breast Cancer Progression....Pages 141-151
TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer....Pages 153-166
Role of Transforming Growth Factor-β in the Kidney — Physiology and Pathology....Pages 167-179
Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis....Pages 181-202
Transforming Growth Factor-β in Brain Functions and Dysfunctions....Pages 203-218
Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment....Pages 219-227
Key Roles of TGF-β and Smad3 in Prostate Cancer....Pages 229-246
Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-β Type I Receptor....Pages 247-261
Front Matter....Pages 263-263
High-Throughput Screening of Protein Interaction Networks in the TGFβ Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression....Pages 265-284
Tumor Suppressor and Pro-progression Roles for TGF-β in Breast Cancer....Pages 285-307
Tumor Suppressors p53 and TGFβ Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker....Pages 309-320
Front Matter....Pages 263-263
TGFβ: Roles in DNA Damage Responses....Pages 321-333
The Rationale for and Effects of Targeting TGF-β for Glioma Therapy....Pages 335-351
Tumor Suppressor Functions of TGFβ1 in T Cells....Pages 353-366
Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-β Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization....Pages 367-381
Role of TGF-β in Tumor Protection and Antitumor Immunity....Pages 383-400
Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1....Pages 401-415
Cancer-Associated Fibroblasts and the Role of TGF-β....Pages 417-441
Adoptive Transfer of Tumor Reactive TGF-β Insensitive CD8 + T-cells for Cancer Therapy....Pages 443-461
DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-β Signaling in Breast Cancer....Pages 463-474
Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-β, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities....Pages 475-505
TGF-β Signaling and Vascular Morphogenesis....Pages 507-521
Aberrant Transforming Growth Factor-β Signaling in Human Pancreatic Cancer: Translational Implications....Pages 523-535
TGF-β and Stromal Influences Over Local Tumor Invasion....Pages 537-551
TGF-β at the Crossroads Between Inflammation, Suppression and Cancer....Pages 553-570
Front Matter....Pages 571-571
Transforming Growth Factor-β (TGF-β) Signaling Inhibitors in Cancer Therapy....Pages 573-587
Targeting TGF-β as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy....Pages 589-608
Targeting Transforming Growth Factor-β in Metastasis: In Vitro and In Vivo Mechanisms....Pages 609-634
Targeted Downregulation of TGF-β2 with AP 12009 in Tumor Therapy....Pages 635-651
Modulating TGF-β Receptor Signaling: A Novel Approach of Cancer Therapy....Pages 653-669
Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action....Pages 671-684
Front Matter....Pages 571-571
The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology....Pages 685-696
Soluble Type II Transforming Growth Factor-β Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity....Pages 697-706
Reversal of EMT by Small-Molecule Inhibitors of TGF-β Type I and II Receptors: Implications for Carcinoma Treatment....Pages 707-722
Soluble TGF-β Type III Receptor Suppresses Malignant Progression of Human Cancer Cells....Pages 723-735
Targeting Smad-Dependent TGF-β Signaling with Peptide Aptamers....Pages 737-756
Rationale for Anti-TGF-β Antibody Therapy in Oncology....Pages 757-774
Back Matter....Pages 775-786