Transdermal Drug Delivery: Concepts and Application

Transdermal Drug Delivery
Copyright
Dedication
Contents
List of figures
List of tables
Preface
Acknowledgment
1 Transcutaneous drug administration
	Passive transdermal therapeutic systems
	References
2 Anatomy of the human skin
	References
3 Basic principles of transdermal drug delivery
	Transdermal drug delivery experiments
	Selection of transdermal drug delivery candidates
	Physico-chemical determinants of percutaneous penetration
		Molecular weight
		Partition coefficient
		Solubility
		Diffusion coefficient
		Ionization
	Biological factors and transdermal drug delivery
		Age
	Hydration
	References
4 Elastic liposomes and other vesicles
	Alpha-tocopherol
	Insulin
	Sodium stibogluconate
	Minoxidil and caffeine
	Asenapine
	Gap junction protein
	Tetanus toxoid
	Ondansetron
	Surfactant-based elastic vesicles
	Niosomes
	Ethosomes
	Cucurmin
	Ovalbumin
	Griseofulvin
	Terbinafine
	Transethosomes
	References
5 Chemical permeation enhancers
	Terpenes
	Water
	Azone
	Pyrrolidone and derivatives
	Alcohols
	Esters
	Dimethyl sulfoxide
	Fatty acids
	Glycol ethers
	Surfactants
	Peptides
	Amino acid derivatives
	Ceramide-like penetration enhancers
	Oleodendrimers
	Ionic liquids and deep eutectic solvents
	References
6 Microemulsions
	Transdermal delivery of indomethacin with microemulsion
	Percutaneous transport of α-santalol through breast skin and mammary papilla
	Skin delivery of propranolol-loaded microemulsions
	The Influence of microemulsion on the percutaneous transport of tetramethylpyrazine
	The influence of microemulsion on the transcutaneous delivery of testosterone
	Transdermal microemulsion loaded with methyl dihydrojasmonate
	The effect of microemulsion on the transcutaneous permeation of dencichine
	Skin delivery of clotrimazole-loaded microemulsions
	Skin delivery of the tetrapeptide PKEK with microemulsions
	Microemulsion for the skin delivery of bee-venom phospholipase A2 (Api m 1)
	Transcutaneous delivery of metronidazole with microemulsion
	Repaglinide microemulsion gel for percutaneous transport
	The influence of microemulsion on the transcutaneous delivery of cyclosporine
	Transcutaneous delivery of lapachol with microemulsion
	Microemulsion for the skin transport of zidovudine
	Percutaneous transport of ropivacaine-loaded microemulsion
	Celecoxib microemulsion-based gel for transdermal delivery
	Skin delivery of imiquimod with microemulsion
	References
7 Prodrugs
	Skin delivery of siRNA with prodrugs
	Skin transport of bioengineered carboxymethyl cellulose-doxorubicin prodrugs
	The effect of ester promoieties on the percutaneous transport of ketorolac
	Percutaneous penetration of apomorphine prodrugs
	Skin delivery of polymer conjugated prodrug of all-trans retinoic acid
	Skin delivery of naproxen prodrugs
	Transdermal delivery of natrexone prodrugs
	Transcutaneous permeation of haloperidol prodrugs
	Skin delivery of fexofenadine prodrugs
	Prodrugs of phenolic compounds
	Polyoxyethylene esters as prodrugs of selected nonsteroidal antiinflammatory drugs for transdermal delivery
	Transdermal delivery of phenylalanyl-glycine prodrugs
	Skin permeation of atenolol and propranolol esters
	The transcutaneous penetration of theophylline prodrugs
	Transdermal delivery of acyclic nucleoside phosphonates
	Percutaneous transport of thalidomide prodrugs
	Transdermal delivery of cytarabine prodrugs
	Transdermal permeation of acetylsalicylic acid prodrugs
	References
8 Microneedles
	Solid microneedles
		Fabrication
		Transdermal drug delivery with solid microneedles
	Dissolving microneedles
	Hollow microneedles
	Coated microneedles
		Dip coating
		Electrohydrodynamic atomization
		Inkjet printing
		Three-dimensional printing
		Spray coating
		Partial immersion
		Nitrogen gas jet coating
		Polyelectrolyte multilayer assembly
	Hydrogel-forming microneedles
	References
9 Iontophoresis, magnetophoresis, and electroporation
	Transdermal iontophoretic delivery of therapeutic agents
		Ranitidine
		Methotrexate
		Penbutolol sulfate
		Almotriptan malate
		3-Fluoroamphetamine
		Acyclovir
		Granisetron
		Memantine
		Ketoprofen
		Dexamethasone
		Donepezil
		3-Fluoroamphetamine
	Magnetophoresis
		WARNING!!! DUMMY ENTRY
			ETP
		ETP-mediated transdermal delivery of doxepin
		Using ETP to transport calcein
	Delivering fentanyl across the human skin with ETP
	Percutaneous transport of metoprolol with ETP
	ETP-mediated transdermal delivery of nalbuphine
	The effect of ETP on the transdermal permeation of doxorubicin
	Delivery of iron with ETP
	ETP-mediated transdermal delivery of Kb-binding ovalbumin-peptide SIINFEKL
	Transcutaneous transport of neostigmine via ETP
	Skin delivery of sinomenine hydrochloride by ETP
	Skin delivery of methotrexate via ETP
	Percutaneous transport of tetracaine via ETP
	ETP-mediated transcutaneous permeation of alniditan
	ETP-assisted skin permeation of heparin
	Transdermal delivery of domperidone via ETP
	ETP-mediated transdermal penetration of diphtheria toxoid
	Percutaneous transport of insulin via ETP
	ETP-mediated percutaneous delivery of andrographolide
	The effect of ETP on the percutaneous absorption of genistein
	ETP-assisted skin transport of insulin
	The influence of ETP on the transcutaneous penetration of terazosin
	ETP-mediated delivery of vaccines against Trypanosoma cruzi
	ETP-mediated skin delivery of pDNA vaccine that codes for the influenza nucleoprotein (PR8)
	References
10 Sonophoresis
	Mechanism of transdermal sonophoresis
		Acoustic streaming
		Cavitation
		Rectified diffusion
		Cellular-level effect
		Thermal effect
	Transdermal sonophoretic delivery of therapeutic agents
		Methotrexate
		Gemcitabine
		Sinomenine
		Penbutolol
		Propranolol
		Ketoprofen
		Diclofenac
		Galantamine
		Rivastigmine
		Lercanidipine hydrochloride
		Insulin
		Heparin
		Histamine
		Caffeine
	References
11 Laser and other ablation technologies
	Heat
	References
12 Mathematical modeling of transdermal drug delivery
	Artificial neural network
	Macroscopic models
	References
Index