Transcription Factors

Front Matter....Pages I-X
Front Matter....Pages 1-1
Mechanisms of Transcriptional Activation in Eukaryotes....Pages 3-31
Multiple Mechanisms of Transcriptional Repression in Eukaryotes....Pages 33-67
Genomic Approaches to the Study of Transcription Factors....Pages 69-93
Front Matter....Pages 97-121
Biological Roles of the STAT Family in Cytokine Signaling....Pages 97-121
Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis....Pages 123-165
Transcription Factors in the Control of Tumor Development and Progression by TGF-β Signaling....Pages 167-207
The p53 Transcription Factor as Therapeutic Target in Cancer....Pages 209-258
The Role of Ets Transcription Factors in Mediating Cellular Transformation....Pages 259-275
Function of the E2F Transcription Factor Family During Normal and Pathological Growth....Pages 277-308
c-Myc in Cellular Transformation and Cancer....Pages 309-323
NF-κB: Critical Regulator of Inflammation and the Immune Response....Pages 325-376
Hepatitis B Virus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis....Pages 377-407
Regulation of Xenobiotic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology....Pages 409-435
Front Matter....Pages 437-437
Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approach....Pages 439-453
Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatment....Pages 455-490
Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine....Pages 491-507
Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications....Pages 509-533
Modulating Transcription with Artificial Regulators....Pages 535-571
Back Matter....Pages 573-581