Toxicology of Chemical Mixtures. Case Studies, Mechanisms, and Novel Approaches

Content: 
Front Matter, Page iii
Copyright, Page iv
Dedication, Page v
Acknowledgment, Page vi
Contributors, Pages xvii-xx
Foreword, Pages xxi-xxiv, Roger O. McClellan
1 - Introduction to the Toxicology of Chemical Mixtures, Pages 1-10, Raymond S.H. Yang
2 - Love Canal: Development of the Toxicologic Evaluation of Its Complex Chemical Contamination, Pages 13-50, Jay B. Silkworth
3 - Toxicology Studies on Mixtures of Chemical Contaminants in the Great Lakes, Pages 51-61, D.C. Villeneuve, I. Chu, C.G. Rousseaux
4 - Health Effect Studies on Recycled Drinking Water from Secondary Wastewater, Pages 63-81, William C. Lauer, Gary W. Wolfe, Lyman W. Condie
5 - Assessing the Carcinogenic Potency of Environmental Coal Tars, By-Products of Coal Gasification, Pages 83-97, Ronald E. Wyzga, Lawrence S. Goldstein
6 - Toxicology of Chemical Mixtures Derived from Hazardous Waste Sites or Application of Pesticides and Fertilizers, Pages 99-117, Raymond S.H. Yang
7 - Diesel Exhaust: An Approach for the Study of the Toxicity of Chemical Mixtures, Pages 119-133, Rogene F. Henderson, Joe L. Mauderly
8 - Toxicologic Problems Associated with Pesticide Mixtures and Pesticide Impurities, Pages 135-155, Janice E. Chambers, Gary D. Dorough
9 - Carcinogenic Hazards from Eating Fish and Shellfish Contaminated with Disparate and Complex Chemical Mixtures, Pages 157-194, James Huff
10 - Immune Alterations Resulting from Exposure to Chemical Mixtures, Pages 197-217, Dori R. Germolec, Michael I. Luster
11 - In Vivo Cytogenetic Effects from Exposure to Chemical Mixtures, Pages 219-243, Andrew D. Kligerman
12 - Multiple Chemical Exposure and Risks of Adverse Reproductive Function and Outcome, Pages 245-297, Robert J. Kavlock, Sally D. Perreault
13 - Mechanism of the Interactive Amplification of Halomethane Hepatotoxicity and Lethality by Other Chemicals, Pages 299-334, Harihara M. Mehendale
14 - Nephrotoxicity Resulting from Multiple Chemical Exposures and Chemical Interactions, Pages 335-360, Jane Ellen Simmons
15 - Effects of Low Level Exposure to Multiple Carcinogens in Combination, Pages 361-382, Ryohei Hasegawa, Shozo Takayama, Nobuyuki Ito
16 - New Approaches to Bioassay- and Biomarker-Directed Identification of Genotoxic Components in Complex Mixtures: DNA Adduct Identification and Mutation Spectra, Pages 385-398, Joellen Lewtas, Leon C. King, David M. DeMarini
17 - Physiologically Based Pharmacokinetic Modeling of Chemical Mixtures, Pages 399-437, Kannan Krishnan, Melvin E. Andersen, J. Clewell Harvey III, Raymond S.H. Yang
18 - Application of Physicochemical Concepts to Mechanistic Elucidation of Toxicologic Interactions, Pages 439-471, Bryan R. Hollebone
19 - Defining Populations Potentially Exposed to Chemical Waste Mixtures Using Computer-Aided Mapping and Analysis, Pages 473-504, John R. Nuckols, Joseph K. Berry, Lorann Stallones
20 - Challenges for in Situ Bioremediation of Chemical Mixtures, Pages 505-538, Kenneth F. Reardon
21 - Chemical Mixture Toxicity Assessment Using an Alternative-Species Model: Applications, Opportunities, and Perspectives, Pages 539-563, Douglas A. Dawson
22 - Approaches and Challenges in Risk Assessments of Chemical Mixtures, Pages 565-597, M.M. Mumtaz, C.T. DeRosa, P.R. Durkin
23 - Statistical Methods for the Toxicological Evaluation of the Additivity Assumption as Used in the Environmental Protection Agency Chemical Mixture Risk Assessment Guidelines, Pages 599-642, David J. Svendsgaard, Richard C. Hertzberg
24 - Analysis of Chemical Combinations: Relating Isobolograms to Response Surfaces, Pages 643-663, Walter H. Carter Jr., Chris Gennings
25 - Potential Effects of Chemical Mixtures on the Carcinogenic Process within the Context of the Mathematical Multistage Model, Pages 665-686, Christopher J. Portier, Claire D. Sherman
Index, Pages 687-720