Toxicology in Transition: Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994

Front Matter....Pages I-IX
Front Matter....Pages 1-1
Concepts, Potentials and Methods for Constructing Transgenic Cells and Animals....Pages 3-7
Use of Recombinant Cells in Metabolic and Mechanistic Studies....Pages 8-22
Applications for Transgenic Animals in Toxicology....Pages 23-34
Front Matter....Pages 35-35
Principles, Benefits and Limitations of the NOEL Approach....Pages 37-43
Comparison of BMD with NOAEL and LOAEL Values Derived from Subchronic Toxicity Studies....Pages 44-54
Front Matter....Pages 55-55
Biomarkers in Ecotoxicology: an Overview....Pages 57-79
Use of cytochrome P450 1A (CYP1A) in fish as a biomarker of aquatic pollution....Pages 80-95
Front Matter....Pages 97-97
Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression....Pages 99-115
Inhibitors of the Sodium Pump: Toxins, then Drugs, and now hormones....Pages 116-124
Rodent Responses To Peroxisome Proliferators — A Receptor-Mediated Phenomenon?....Pages 125-133
Role of Second Messengers in Mineral Particle-Induced Production of Reactive Oxygen Species by Phagocytes....Pages 134-147
Estrogenic Effects of Some Xenobiotics....Pages 148-152
Front Matter....Pages 153-153
 In Vitro Methods in Regulatory Toxicology: The Crucial Significance of Validation....Pages 155-162
Scientific, ethical and legal aspects of the acceptance of in vitro methods in regulatory toxicology....Pages 163-169
The Validation and Use of In Vitro Teratogenicity Tests....Pages 170-191
In Vitro Methods in Regulatory Toxicology....Pages 192-204
 In Vitro Tests in Regulatory Toxicology: Symposium Chairman’s Summing-up....Pages 205-208
 Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism....Pages 209-214
Rabbit Renal Proximal Tubule Suspensions as a Model for Nephrotoxicity Evaluation of Native or in situ Metabolized β-Lactam Antibiotics....Pages 215-217
Front Matter....Pages 219-219
Neurobehavioral Abnormalities Induced by Prenatal Exposure to Substances of Abuse — Stating the Problems....Pages 221-232
Front Matter....Pages 219-219
Prenatal Exposure to Marihuana and Tobacco During Infancy, Early and Middle Childhood: Effects and an Attempt at Synthesis....Pages 233-260
Delayed Developmental Neuro- and Immunotoxicity of Benzodiazepines....Pages 261-287
Changes in EEG of freely-moving rats caused by three-generation organophosphate treatment....Pages 288-294
Developmental Neurotoxicity of Carbon Monoxide....Pages 295-301
Front Matter....Pages 303-303
The Safety Assessment of Over-The-Counter (OTC) Products....Pages 305-311
OTC Pharmaceuticals and Genotoxicity Testing: The Paracetamol, Anthraquinone, and Griseofulvin Cases....Pages 312-325
Safety Assessment of OTC Drugs: Doxylamine Succinate....Pages 326-340
Safety Assessment of OTC Products — A Regulatory View....Pages 341-345
Drug toxicity findings and no action taken....Pages 346-348
Front Matter....Pages 349-349
Species Specificity of Organ Toxicity....Pages 351-356
Species Specificity at the Molecular Level: the Case of Nitric Oxide Synthases....Pages 357-366
Mechanisms Underlying Species-Specificity in Target Organ Toxicity....Pages 367-374
Species Specificity of Organ Toxicity: Behavioral Differences....Pages 375-394
Front Matter....Pages 395-395
Development of OECD Test Guidelines and Hazard Assessment Procedures for Terrestrial Effects....Pages 397-405
Development of Guidance for Terrestrial Effects Assessment....Pages 406-419
Application of Quick and Simple Plant Bioassays to Assess the Genotoxicity of Environmental Pollutants — Detection of Potential Health Hazards of Air, Water and Soil contaminants....Pages 420-433
Comparison of susceptibilities of species used in toxicological and environmental risk assessment to chemicals (pesticides)....Pages 434-445
Toxicological Evaluation of Pollutants in Soil — Concept of the AGU and Assessment of Tolerable Concentrations for Metals....Pages 446-452
Front Matter....Pages 453-453
The SCID (Severe Combined Immunodeficiency) Mouse — Its Biology and Use in Immunotoxicological Research....Pages 455-467
The SCID Mouse as a Tool to Bridge the Gap Between Animal and Human Responses....Pages 468-471
Front Matter....Pages 453-453
The SCID Mouse and its use for Immunopharmacological and Immunotoxicological Investigations....Pages 472-487
Front Matter....Pages 489-489
Chirality — from Molecules to Organisms....Pages 491-498
Interactions between the in vitro metabolism of xenobiotics and fatty acids....Pages 499-513
Side effects and toxic reactions of chiral drugs: A clinical perspective....Pages 514-521
Analysis of (S)- and (R)-Propranolol in Human Plasma and Urine by a Specific Immunoenzymatic Assay versus HPLC....Pages 522-527
Front Matter....Pages 529-529
Biological Behavior of Prestages of Cancer Cells: An Introduction....Pages 531-535
Preneoplastic Lesions In Kidney And Carcinogenesis By Non-Genotoxic Compounds....Pages 536-546
Early Cellular Alterations in Chemical Liver Carcinogenesis as Assessed by Immunohistochemical and Molecular Biological Techniques....Pages 547-553
Front Matter....Pages 555-555
The UK Approach to the Regulation and Evaluation of Novel Foods Produced by Biotechnology....Pages 557-561
Front Matter....Pages 563-563
Molecular Mimicry of CF 3 CO-Lysine by Lipoic Acid I: The Dihydrolipoamide Acetyltransferase Subunit of the Human Pyruvate Dehydrogenase as Autoantigen in Halothane Hepatitis....Pages 565-565
Molecular Mimicry of CF 3 CO-Lys by Lipoic Acid II: Lipoic Acid Bearing Proteins as Autoantigens in Halothane Hepatitis....Pages 566-566
Back Matter....Pages 567-570