Toxicology and Epigenetics

ویرایش:  
 
سری:  
ISBN (شابک) : 9781119976097, 9781118349045 
ناشر:  
سال نشر: 2012 
تعداد صفحات: 668 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 7 مگابایت 

قیمت کتاب (تومان) : 46,000

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:

• environment, epigenetics and diseases
• DNA methylation and toxicogenomics
• chromatin at the intersection of disease and therapy
• epigenomic actions of environmental arsenicals
• environment, epigenetics and cardiovascular health
• toxicology, epigenetics and autoimmunity
• ocular epigenomics: potential sites of environmental impact in development and disease
• nuclear RNA silencing and related phenomena in animals
• epigenomics – impact for drug safety sciences
• methods of global epigenomic profiling
• transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Content:
Chapter 1 Introduction (pages 1–3): Saura C. Sahu
Chapter 2 Environment, Epigenetics, and Diseases (pages 5–24): Robert Y. S. Cheng and Wan?yee Tang
Chapter 3 DNA Methylation and Toxicogenomics (pages 25–50): Deepti Deobagkar
Chapter 4 Chromatin at the Intersection of Disease and Therapy (pages 51–71): Delphine Quenet, Marcin Walkiewicz and Yamini Dalal
Chapter 5 Molecular Epigenetic Changes Caused by Environmental Pollutants (pages 73–109): Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. Sepulveda
Chapter 6 Epigenetic Mediation of Environmental Exposures to Polycyclic Aromatic Hydrocarbons (pages 111–127): Bekim Sadikovic and David I. Rodenhiser
Chapter 7 Epigenomic Actions of Environmental Arsenicals (pages 129–148): Paul L. Severson and Bernard W. Futscher
Chapter 8 Arsenic?Induced Changes to the Epigenome (pages 149–190): Kathryn A. Bailey and Rebecca C. Fry
Chapter 9 Environmental Epigenetics, Asthma, and Allergy: Our Environment's Molecular Footprints (pages 191–203): Stephanie Lovinsky?Desir and Rachel L. Miller
Chapter 10 miRNAs in Human Prostate Cancer (pages 205–217): Ernest K. Amankwah and Jong Y. Park
Chapter 11 Environment, Epigenetics, and Cardiovascular Health (pages 219–239): Sanjukta Ghosh and Andrea Baccarelli
Chapter 12 Toxicology, Epigenetics, and Autoimmunity (pages 241–260): Craig A. Cooney and Kathleen M. Gilbert
Chapter 13 Toxicoepigenomics in Lupus (pages 261–274): Donna Ray and Bruce C. Richardson
Chapter 14 Ocular Epigenomics: Potential Sites of Environmental Impact in Development and Disease (pages 275–295): Kenneth P. Mitton
Chapter 15 Nuclear RNA Silencing and Related Phenomena in Animals (pages 297–315): Radek Malik and Petr Svoboda
Chapter 16 Epigenetic Biomarkers in Cancer Detection and Diagnosis (pages 317–338): Ashley G. Rivenbark and William B. Coleman
Chapter 17 Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic (pages 339–356): John F. Reichard and Alvaro Puga
Chapter 18 Irreversible Effects of Diethylstilbestrol on Reproductive Organs and a Current Approach for Epigenetic Effects of Endocrine Disrupting Chemicals (pages 357–364): Shinichi Miyagawa, Ryohei Yatsu, Tamotsu Sudo, Katsuhide Igarashi, Jun Kanno and Taisen Iguchi
Chapter 19 Epigenomics – Impact for Drug Safety Sciences (pages 365–385): Harri Lempiainen, Raphaelle Luisier, Arne Muller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs and Remi Terranova
Chapter 20 Archival Toxicoepigenetics: Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies (pages 387–407): B. Alex Merrick
Chapter 21 Nanoparticles and Toxicoepigenomics (pages 409–426): Manasi P. Jain, Angela O. Choi and Dusica Maysinger
Chapter 22 Methods of Global Epigenomic Profiling (pages 427–443): Michael W. Y. Chan, Zhengang Peng, Jennifer Chao Weber, Ying?Wei Li, Matthew T. Zuzolo and Huey?Jen L. Lin
Chapter 23 Transcriptomics: Applications in Epigenetic Toxicology (pages 445–458): Pius Joseph
Chapter 24 Carcinogenic Metals Alter Histone Tail Modifications (pages 459–474): Yana Chervona and Max Costa
Chapter 25 Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure (pages 475–510): Yoko Hirabayashi and Tohru Inoue
Chapter 26 Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins (pages 511–538): Marjorie Brand and F. J. Dilworth
Chapter 27 Chromatin Insulators and Epigenetic Inheritance in Health and Disease (pages 539–567): Jingping Yang and Victor G. Corces
Chapter 28 Bioinformatics for High?Throughput Toxico?Epigenomics Studies (pages 569–588): Maureen A. Sartor, Dana C. Dolinoy, Laura S. Rozek and Gilbert S. Omenn
Chapter 29 Computational Methods in Toxicoepigenomics (pages 589–593): Joo Chuan Tong
Chapter 30 Databases and Tools for Computational Epigenomics (pages 595–614): V. Umashankar and S. Gurunathan
Chapter 31 Interface of Epigenetics and Carcinogenic Risk Assessment (pages 615–630): Paul Nioi
Chapter 32 Epigenetic Modifications in Chemical Carcinogenesis (pages 631–643): Igor P. Pogribny, Igor Koturbash and Frederick A. Beland
Chapter 33 Application of Cancer Toxicoepigenomics in Identifying High?Risk Populations (pages 645–652): Mukesh Verma and Krishna K. Banaudha

 Content: Environment, Epigenetics and Diseases / Robert Y.S. Cheng and Wan-yee Tang --
 DNA Methylation and Toxicogenomics / Deepti Dileep Deobagkar --
 Chromatin at the Intersection of Disease and Therapy / Delphine Quénet, Marcin Walkiewicz and Yamini Dalal --
 Molecular Epigenetic Changes Caused by Environmental Pollutants / Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. Sepulveda --
 Epigenetic mediation of environmental exposures to Polycyclic Aromatic Hydrocarbons / Bekim Sadikovic and David I. Rodenhiser --
 Epigenomic Actions of Environmental Arsenicals / Paul L. Severson & Bernard W. Futscher --
 Arsenic-induced Changes to the Epigenome / Kathryn A. Bailey and Rebecca C. Fry --
 Environmental Epigenetics, Asthma and Allergy : Our environment\'s Molecular Footprints / Stephanie Lovinsky-Desir and Rachel L. Miller --
 miRNAs in Human Prostate Cancer / Ernest K. Amankwah and Jong Y. Park --
 Environment, Epigenetics and Cardiovascular Health / Sanjukta Ghosh and Andrea Baccarelli --
 Toxicology, Epigenetics and Autoimmunity / Craig A. Cooney and Kathleen M. Gilbert --
 Toxicoepigenomics in Lupus / Donna Ray and Bruce C. Richardson --
 Ocular Epigenomics : Potential Sites of Environmental Impact in Development and Disease / Kenneth P. Mitton --
 Nuclear RNA Silencing and Related Phenomena in Animals / Radek Malik and Petr Svoboda --
 Epigenetic Biomarkers in Cancer Detection and Diagnosis / Ashley G. Rivenbark and William B. Coleman --
 Epigenetic Histone Changes in the Toxicologic mode of action of Arsenic / John F. Reichard and Alvaro Puga. Irreversible Effect of Diethylstilbestrol on Reproductive Organs and Current Approach for Epigenetic Effects of Endocrine Disrupting Chemicals / Shinichi Miyagawa, Ryohei Yatsu, Tamotsu Sudo, Katsuhide Igarashi, Jun Kanno, and Taisen Iguchi --
 Epigenomics : Impact for Drug Safety Sciences / Harri Lempiäinen, Raphaelle Luisier, Arne Muller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs, and Rémi Terranova --
 Archival Toxicoepigenetics : Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies / B. Alex Merrick --
 Nanoparticles and Toxicoepigenomics / Manasi P. Jain, Angela O. Choi, and Dusica Maysinger --
 Methods of Global Epigenomic Profiling / Michael W.Y. Chan, Zhengang Peng, Jennifer R. Chao, Yingwei Li, Matthew T. Zuzolo, and Huey-Jen L. Lin --
 Transcriptomics : Applications in Epigenetic Toxicology / Pius Joseph --
 Carcinogenic metals alter histone tail modifications / Yana Chervona and Max Costa --
 Prediction of epigenetic and stochastic gene expression profiles of late effects after radiation exposure / Yoko Hirabayashi and Tohru Inoue --
 Modulation of developmentally regulated gene expression programs through targeting of polycomb and trithorax group proteins / Marjorie Brand and F. Jeffrey Dilworth --
 Chromatin Insulators and Epigenetic Inheritance in Health and Disease / Jingping Yang and Victor G. Corces --
 Bioinformatics for High-Throughput Toxico-epigenomics Studies / Maureen A. Sartor, Dana C. Dolinoy, Laura S. Rozek, and Gilbert S. Omenn --
 Computational Methods in Toxicoepigenomics / Joo Chuan Tong --
 Databases and Tools for Computational Epigenomics / V. Umashankar and S. Gurunathan --
 Interface of Epigenetics and Carcinogenic Risk Assessment / Paul Nioi --
 Epigenetic Modifications in Chemical Carcinogenesis / Igor P. Pogribny, Igor Koturbash, and Frederick A. Beland --
 Application of Cancer Toxicoepigenomics in Identifying High-Risk Populations / Mukesh Verma and Krishna K Banaudha.