Toxicological profiles - Ethylene oxide

TOXICOLOGICAL PROFILE FOR ETHYLENE OXIDE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.1 WHAT IS ETHYLENE OXIDE?......Page 12
1.4 HOW CAN ETHYLENE OXIDE AFFECT MY HEALTH?......Page 13
1.5 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 14
1.7 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO PROTECT HUMAN HEALTH?......Page 15
1.8 WHERE CAN I GET MORE INFORMATION?......Page 20
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 22
2.2.1.2 Systemic Effects......Page 23
2.2.1.3 Immunological Effects......Page 32
2.2.1.4 Neurological Effects......Page 33
2.2.1.6 Reproductive Effects......Page 35
2.2.1.8 Cancer......Page 36
2.2.2.1 Death......Page 37
2.2.2.2 Systemic Effects......Page 38
2.2.2.8 Cancer......Page 41
2.2.3.2 Systemic Effects......Page 42
2.3.1.1 Inhalation Exposure......Page 43
2.3.3 Metabolism......Page 44
2.3.4.3 Dermal Exposure......Page 46
2.4 RELEVANCE TO PUBLIC HEALTH......Page 47
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 52
2.8 ADEQUACY OF THE DATABASE......Page 53
2.8.2 Identification of Data Needs......Page 54
2.8.3 On-going Studies......Page 58
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 61
4.3 USE......Page 64
4.4 DISPOSAL......Page 65
5.2.1 Air......Page 66
5.2.3 Soil......Page 67
5.3.1 Transport and Partitioning......Page 68
5.3.2.2 Water......Page 69
5.4.4 Other Media......Page 70
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 71
5.7 ADEQUACY OF THE DATABASE......Page 72
5.7.1 Identification of Data Needs......Page 73
5.7.2 On-going Studies......Page 74
6.2 ENVIRONMENTAL SAMPLES......Page 76
6.3 ADEQUACY OF THE DATABASE......Page 77
6.3.1 Identification of Data Needs......Page 80
6.3.2 On-going Studies......Page 81
7. REGULATIONS AND ADVISORIES......Page 82
8. REFERENCES......Page 85
Developmental Toxicity......Page 106
Malformations......Page 107
Short-Term Exposure Limit......Page 108
Uncertainty Factor......Page 109
PEER REVIEW......Page 111