Toxicological profiles - Chlorobenzene

TOXICOLOGICAL PROFILE FOR  CHLOROBENZENE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO CHLOROBENZENE?......Page 10
1.4 HOW CAN CHLOROBENZENE AFFECT MY HEALTH?......Page 11
1.6 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO CHLOROBENZENE?......Page 15
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 21
2.2.1.1 Death......Page 22
2.2.1.2 Systemic Effects......Page 23
2.2.1.4 Neurological Effects......Page 27
2.2.2.1 Death.......Page 28
2.2.2.2 Systemic Effects......Page 29
2.2.2.3 Immunological Effects......Page 33
2.2.2.8 Cancer......Page 34
2.3.1.1 Inhalation Exposure......Page 35
2.3.3 Metabolism......Page 36
2.3.4.1 Inhalation Exposure......Page 37
2.4 RELEVANCE TO PUBLIC HEALTH......Page 39
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 43
2.7 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 45
2.8.1 Existing Information on Health Effects of Chlorobenzene......Page 46
2.8.2 Identification of Data Needs......Page 48
2.8.3 Ongoing Studies......Page 50
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 51
4.4 DISPOSAL......Page 54
5.2.2 Water......Page 55
5.2.3 Soil......Page 56
5.4.1 Air......Page 57
5.7 ADEQUACY OF THE DATABASE......Page 58
5.7.1 Identification of Data Needs......Page 59
6.1 BIOLOGICAL MATERIALS......Page 60
6.2 ENVIRONMENTAL SAMPLES......Page 61
6.3 ADEQUACY OF THE DATABASE......Page 64
6.3.2 Ongoing Studies......Page 67
7. REGULATIONS AND ADVISORIES......Page 68
8. REFERENCES......Page 73
Developmental Toxicity......Page 84
Minimal Risk Level......Page 85
Target Organ Toxicity......Page 86
User s Guide......Page 87
Acronyms, Abbreviations, and Symbols......Page 92
Peer Review......Page 96