Toxicological Aspects of Food Safety: Proceedings of the European Society of Toxicology. Meeting held in Copenhagen, June 19–22, 1977

Front Matter....Pages I-XI
Young Scientists Award Lecture 1977: An Investigation into the Value of Some Clinical Biochemical Tests in the Detection of Minimal Changes in Liver Morphology and Function in the Rat....Pages 1-13
Toxicological Aspects of Food Safety....Pages 15-21
Nutritional Evaluation of Low-Erucic-Acid Rapeseed Oils....Pages 23-32
Food Additives....Pages 33-46
Pesticides and Heavy Metals as Food Contaminants....Pages 47-54
Toxicokinetics....Pages 55-67
Toxicological Aspects of Food Safety — Carcinogenicity and Mutagenicity....Pages 69-84
Significance of Induction Phenomena....Pages 85-99
Evaluation of Food Safety. National and International Aspects....Pages 101-106
Drug Biotransformation and Hepatotoxicity. Studies with Bromobenzene in Isolated Hepatocytes....Pages 107-114
Hepatotoxicity of Bile Acids with Special Reference to Cheno-Treatment....Pages 115-115
Metabolic Activation of Methyldopa and Other Catechols....Pages 117-124
Clinical Aspects of Drug-Induced Hepatitis....Pages 125-130
Hepatotoxicity in Patients with Liver Disease....Pages 131-136
Halothane Hepatitis....Pages 137-139
Hypersensitivity Reactions to Food Colours with Special Reference to the Natural Colour Annatto Extract (Butter Colour)....Pages 141-143
The Use of Radionuclides for the Quantitative Evaluation of Drug Local Irritancy....Pages 145-145
Stimulation of DNA Synthesis in Mouse and Rat Lung Following Administration of Butylated Hydroxytoluene....Pages 147-150
Effects of Rapidly Phosphorylated Substrates Fructose, Sorbitol, Xylitol (Glycerol): Toxic or Metabolic....Pages 151-155
Study and Evaluation of Organic Lead Levels in Fishes and Phytoplankton Near Otranto....Pages 157-157
Drug-Induced Changes in Serum Alkaline Phosphatase and Alanine Aminotransferase Activities not Related to Hepatic Injuries....Pages 159-163
Evaluation of Organ Weight Differences in Toxicological Experiments....Pages 165-168
Comparative Cardiovascular Toxicity of Trazodone and Imipramine in the Rat....Pages 169-172
Liver Injury and Multiple Drug Therapy....Pages 173-176
Hepatotoxicity of Citalopram in Rats and First-Pass Metabolism....Pages 177-180
Toxicologic Findings of 3-Aryl-triene-steroidal-16,17-Acetonamide (ATSA)....Pages 181-181
Biochemical Effects of Chronically Administered Suspending Agents on Mitochondrial Metabolism and Hepatic Mixed Function Oxidases in Rat, Mice, and Hamster....Pages 183-187
Effect of Ethylenethiourea on Hepatic Microsomal Enzymes in the Rat....Pages 189-192
Comparative Study of the Protective Effect of an Anabolic Steroid....Pages 193-196
Experimental Study of Bonaphthon in the Maternal-Embryonic Complex....Pages 197-197
Chimpanzees Sulfate Lithocholate Similar to Man....Pages 199-199
Influence of Some Thiol Compounds on the CCl 4 Hepatotoxicity....Pages 201-201
Thromboelastography Behaviour in Rats Submitted to Experimental Liver Intoxication....Pages 203-203
Routine Clinical Electroretinography in Dogs....Pages 205-205
A New Procedure for Estimation of Nitrovin and Carbadox Residues and Their Metabolites in Food of Animal Origin....Pages 207-210
Glutathione Turnover in Isolated Hepatocytes....Pages 211-211
Covalent Binding of 2,4-Diaminoanisole and 2,4-Diaminotoluene in vivo....Pages 213-217
Comparative Research of Certain Methods in Evaluation of Hepatotoxicity of Chemical Agents....Pages 219-219
Hepatotoxic Effect of Thioacetamide (TAM) on NADP-Linked Enzymes, Aminotransferases and Glutamate Dehydrogenase....Pages 221-224
A Histological Review of the Rat Liver Poisoned by Carbontetrachloride and Treated by Piracetam....Pages 225-225
The Effect of Piracetam in Rats Poisoned by Carbontetrachloride....Pages 227-227
Hepato- and Thyreotoxicity of Tifemoxone....Pages 229-233
Toxicological Studies on a New Veterinary Antibiotic Turimycin....Pages 235-237
Metabolism of 2,4,5,2′,5′-Pentachlorobiphenyl by Lung and Liver Microsomes....Pages 239-242
Hepatic Clearance and Disposition of Hydroxyethylrutosides....Pages 243-246
Changes in the Hepatic Copper Content after Treatment with Foreign Compounds....Pages 247-249
Absorption and Excretion of 1-Amino-2-Naphthol-6-Sulphonic Acid in Rats and Rabbits....Pages 251-254
Drug Excretion into Eggs. An Autoradiographic Study....Pages 255-257
The Metabolism of 3 H-Benzo(a)pyrene by Hepatic Microsomes from Rats Treated with Tetrachlorodibenzo-p-dioxin....Pages 259-259
Induction of Drug Metabolizing Enzymes in Different Rat Tissues by TCDD....Pages 261-265
Lysosomal Enzymes in Hepatic Injury Induced by Bromobenzene....Pages 267-270
Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment....Pages 271-273
A Simple and Sensitive Assay of 7-Ethoxycoumarin in Deethylation....Pages 275-275
Induction of Arylhydrocarbon Hydroxylase and UDP Glucuronosyl Transferase by PCB in Hepatic Cell Cultures....Pages 277-279
Enhancement of Cytosolic Carboxylesterase by Phenobarbital in the Rat....Pages 281-283
A New Method for Hepatocyte Function Exploration (T.M.B. Test) Applied to the Rat in Experimental Toxicology....Pages 285-285
Modifying Effects of Styrene on the Catalytic Properties of Some Microsomal Enzymes....Pages 287-290
Specific Modification of the Properties of the N-Hydroxylase....Pages 291-294
A Very Sensitive Gas Chromatographic Method for the Evaluation of Styrene Oxidase and Styrene Oxide Hydratase Activities....Pages 295-298
A Gas Chromatographic Method for the Evaluation of the Vinyl Epoxidase Activity....Pages 299-302
The Fate of Curcumin in the Rat....Pages 303-303
The Use of Food Additives in Sweden....Pages 305-308
Hemiglobin Formation in vitro Induced by Azo Dyes and Their Metabolites....Pages 309-311
Peroral Toxicity of Orange RN in Pigs. Early Haemotological Changes....Pages 313-315
Peroral Toxicity of Orange RN in Pigs. Ultrastructure of Hepatic Lesions....Pages 317-317
Toxicology of Triethyllead, Methylmercury and Cadmium, Determined in Chick Embryo Brain Cell Cultures....Pages 319-322
Reversible Inhibition of Spermatogenesis with an Indenopyridine (20–438)....Pages 323-326
Relative Teratogenicity of Selected Anhydrides....Pages 327-327
Effects of Rapeseed Oil Compared to Hydrogenated Marine Oil in Rats. Histopathological Effects of Erucic Acid and Isomers on the Heart....Pages 329-330
Changes in Liver Tyrosine Aminotransferase after Acute and Chronic Administration of Morphine in the Rat....Pages 331-333
Retarded Elimination of a High-Molecular Enzyme-Substrate-Complex after Hydroxyethyl-Starch-Infusion....Pages 335-338
Drug Metabolism in Man: in vivo and in vitro Correlations....Pages 339-342
Pharmacokinetics of Dextropropoxyphene in Acute Poisoning....Pages 343-346
Suitability of Different Breeds of Rabbits for Experimental Atherosclerosis....Pages 347-347
Results of Comparative Toxicity Tests on Mini-Pigs, Beagles and Wistar-Rats with d-Norgestrel....Pages 349-349
Metabolism of L(+)- and D(-)-Tartaric Acids in Different Animal Species....Pages 351-353
Influence of Diet and Strain of Rat on Kidney Damage Observed in Toxicity Studies....Pages 355-358
Influence of Drugs on Bile Acid Excretion....Pages 359-361
Pharmacological Properties of the Optical Isomers of Ketamine....Pages 363-363
The Influence of Arrhythmogenic Substances on the E.C.G. of Rats Calcified by High Doses of Vitamin D 2 ....Pages 365-368
Extrapolation of Carcinogenicity Data to Low Doses with a Dose-Response Study of the Binding of Benzo(a)pyrene to Rat Liver DNA....Pages 369-371
A Closed Inhalation System for Pharmacokinetic and Metabolism Studies of Volatile Compounds with Small Laboratory Animals....Pages 373-375
Effects of Diazepam on DFP Intoxicated Mice in the Absence and Presence of Obidoxime....Pages 377-377
Pharmacological and Toxicological Investigations on the New Bulgarian Drug Lonetil....Pages 379-379
Metabolism of Benzo(a)pyrene Catalyzed by Human Lung Microsomes....Pages 381-381
Stimulation of the Synthesis, in vivo, of Zoxazolamine Hydroxylase in Young Female Rat by Bixa orellana L. Extract....Pages 383-383
Structural and Biochemical Changes in Rat Hepatic and Extrahepatic Tissues Following a Single Oral Dose of TCDD....Pages 385-385
Back Matter....Pages 387-392