Toward a Molecular Basis of Alcohol Use and Abuse

Front Matter....Pages I-X
Alcohol in human history....Pages 1-8
Reward and its control by dynorphin peptides....Pages 9-17
Adaptation of signal transduction in brain....Pages 19-28
Protein kinase C and adaptation to ethanol....Pages 29-38
Molecular control of neuronal survival in the chick embryo....Pages 39-48
Effects of alcohol on gene expression in neural cells....Pages 49-59
The role of the NMDA receptor in ethanol withdrawal....Pages 61-70
Molecular diversity of glutamate receptors and their physiological functions....Pages 71-80
Multiple dopamine receptors: The D 3 receptor and actions of substances of abuse....Pages 81-92
Molecular pharmacology of serotonin receptors....Pages 93-102
Alcohol, the reward system and dependence....Pages 103-114
Clinical aspects on molecular probes, markers and metabolism....Pages 115-120
Familial alcoholism: Family, twin adoption and high risk studies....Pages 121-131
Association strategies in substance abuse....Pages 133-141
PET-determination of benzodiazepine receptor binding in studies on alcoholism....Pages 143-153
Serotonin, violent behavior and alcohol....Pages 155-163
Neuropeptides and alcohol addiction in monkeys....Pages 165-174
The role of adenosine in mediating cellular and molecular responses to ethanol....Pages 175-183
 Helicobacter pylori alcohol dehydrogenase....Pages 185-195
Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity....Pages 197-207
Serotonin-altering medications and desire, consumption and effects of alcohol-treatment implications....Pages 209-219
The alcohol dehydrogenase system....Pages 221-229
Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity....Pages 231-240
Recruitment of enzymes and stress proteins as lens crystallins....Pages 241-250
X-ray structure of PQQ-dependent methanol dehydrogenase....Pages 251-260
NMR, alcohols, protein solvation and protein denaturation....Pages 261-268
Crystallographic investigations of alcohol dehydrogenases....Pages 269-277
Retinoids and the alcohol dehydrogenase gene family....Pages 279-290
Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism....Pages 291-300
Site-directed mutagenesis and enzyme properties of mammalian alcohol dehydrogenases correlated with their tissue distribution....Pages 301-309
Control of alcohol metabolism....Pages 311-322
Angiotensin converting enzyme inhibitors and alcohol abuse....Pages 323-331
Treatment of alcoholism....Pages 333-340
Alcohol sensitivity and dependence....Pages 341-348
Treatment of alcoholism as a chronic disorder....Pages 349-359
Addiction and the potential for therapeutic drug development....Pages 361-370
Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology....Pages 371-381
Potential gene therapy for alcoholism....Pages 383-393
Outlook: Prospects for alcoholism treatment....Pages 395-404
Back Matter....Pages 405-409