Total Intravenous Anesthesia and Target Controlled Infusions: A Comprehensive Global Anthology

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
When and How Did It All Begin? A Brief History of Intravenous Anesthesia....Pages 3-8
The Development and Regulation of Commercial Devices for Target-Controlled Drug Infusion....Pages 9-29
The Memory Labyrinth: Systems, Processes, and Boundaries....Pages 31-62
Consciousness and Anesthesia....Pages 63-78
Mechanisms of Intravenous Anesthetic Action....Pages 79-95
Front Matter....Pages 97-97
Basic Pharmacology: Kinetics and Dynamics for Dummies....Pages 99-116
Pharmacokinetic–Pharmacodynamic Modelling of Anesthetic Drugs....Pages 117-145
Principles of Target-Controlled Infusions....Pages 147-157
Performance of Target-Controlled Infusion Systems....Pages 159-170
How to Select a PK/PD Model....Pages 171-187
Front Matter....Pages 189-189
Propofol PK-PD....Pages 191-208
Etomidate and Etomidate Analogues: Molecular Pharmacology and Behavioral Actions....Pages 209-219
Dexmedetomidine: The Science and Clinical Aspects in Adults and Children....Pages 221-244
Clinical Effects and Applications of Ketamine....Pages 245-265
Neuromuscular Blocking Drugs: Physiology, Pharmacology and Clinical Aspects....Pages 267-297
New and Upcoming Drugs: Intravenous Anesthetic Agents....Pages 299-312
Drug Interactions in Anesthesia....Pages 313-325
Front Matter....Pages 327-327
Pump Pitfalls and Practicalities....Pages 329-340
EEG Monitoring of Depth of Anesthesia....Pages 341-356
Monitoring the Analgesic Component of Anesthesia....Pages 357-368
Front Matter....Pages 327-327
Intravenous Drugs for Sedation: Target-Controlled, Patient-Controlled and Patient-Maintained Delivery....Pages 369-390
Pediatric TIVA/TCI: Case Presentations and Discussion....Pages 391-401
TCI/TIVA Adult Case Studies....Pages 403-425
Front Matter....Pages 427-427
Intravenous Anesthesia in Obese Patients....Pages 429-440
Pharmacokinetics and Pharmacodynamics in the Pediatric Patient....Pages 441-516
Clinical Pharmacology of Intravenous Sedation in Children....Pages 517-535
Sedation of the Critically Ill Child....Pages 537-560
TCI and TIVA for Neurosurgery: Considerations and Techniques....Pages 561-569
TCI in Special Patients Groups: The Elderly and Obese....Pages 571-578
TIVA for Cardiac Surgery....Pages 579-588
TIVA/TCI in Veterinary Practice....Pages 589-618
Front Matter....Pages 619-619
Advantages, Disadvantages, and Risks of TIVA/TCI....Pages 621-631
Economics of TIVA....Pages 633-638
Teaching TCI with Human Patient Simulators....Pages 639-648
Closed-Loop or Automated Titration of Intravenous Anesthesia: Background, Science, and Clinical Impact....Pages 649-666
Health Care Technology, the Human–Machine Interface, and Patient Safety During Intravenous Anesthesia....Pages 667-683
Can IV Sedatives Affect Outcome?....Pages 685-696
The Benefit and Future of Pharmacogenetics....Pages 697-711
Lessons From Drug Interaction Displays....Pages 713-723
The Role of Intravenous Agents in Delirium....Pages 725-748
Front Matter....Pages 619-619
Perioperative Cardioprotective Strategies in Noncardiac Surgery....Pages 749-761
Opioid-Induced Hyperalgesia After Surgery: Clinical Relevance....Pages 763-773
Memory, Awareness and Intravenous Anesthetics....Pages 775-782
Awareness and Dreaming During TIVA....Pages 783-796
Apoptosis and Neurocognitive Effects of IV Anesthetics....Pages 797-803
Back Matter....Pages 805-824