Topics in Pathophysiology of Hypertension

Front Matter....Pages I-XV
Introduction: Membrane Transport....Pages 1-2
Biomembrane Abnormalities in Spontaneous Hypertension....Pages 3-13
Erythrocyte Na + Handling in Rat Genetic Hypertension....Pages 14-20
CA 2+ Binding by the Erythrocyte Membrane and its Structure in Primary and Secondary Hypertension....Pages 21-30
Calmodulin-Dependent Calcium Transport in Erythrocytes in Primary Hypertension....Pages 31-39
The Na + /K + Co-Transport System in Erythrocytes from Essential Hypertensive Patients....Pages 40-55
Sodium, Lithium, and Potassium Co- and Counter-Transport in Erythrocytes and its Relation to Essential Hypertension....Pages 56-77
Familial Aggregation of Sodium Countertransport and Co-Transport and Essential Hypertension....Pages 78-87
Red Cell Sodium-Lithium Countertransport in Hypertension....Pages 88-99
Hypertension: Multiple Membrane Malfunctions....Pages 100-111
Preliminary Analysis of Sodium-Lithium Countertransport and Blood Pressure in Utah Pedigrees....Pages 112-135
Cation Transport Abnormalities in Human and Rat Essential Hypertension....Pages 136-146
The Sodium/Lithium Exchange Mechanism in Essential Hypertension: Is it a Sodium/Proton Exchanger?....Pages 147-161
Ouabain-Sensitive and -Insensitive Cation Transport in in Normotensives and Hypertensives in Hypokalemic States....Pages 162-171
Presynaptic α-Autoreceptors: Pharmacological Properties and Physiological Function....Pages 172-186
The Effects of Dids and Anion Substitution on Aortic 36 Cl Turnover in Aldosterone-Induced Hypertensive Rats....Pages 187-195
Function of the Sodium Pump in Vascular Smooth Muscle in Hypertension....Pages 196-211
Evidence against Raised Intracellular Sodium Causing Myogenic Contraction in Rat Resistance Vessels....Pages 212-222
Role of an Ouabain-Like Humoral Agent and the Sodium-Potassium Pump in Low-Renin Hypertension....Pages 223-238
An Increase in a Circulating Inhibitor of Na + /K + -ATPase: The Link between Sodium and Vascular Tone in Experimental and Inherited Hypertension?....Pages 239-260
The Role of Sodium-Calcium Exchange in the Genesis of Essential Hypertension....Pages 261-272
Introduction: Neural Control....Pages 273-274
Evidence for the Participation of Specific Hypothalamic Pathways in the Pathogenesis of Hypertension....Pages 275-281
Neuropeptides in the Central Regulation of Blood Pressure....Pages 282-290
The Role of Various Afferents in the Regulation of Sympathetic Tone in Hypertension: A Brief Review....Pages 291-303
Defects in Signal Generation in Arterial Baroreceptors....Pages 304-312
Influence of Sodium Intake on the Neurogenic Contribution in Hypertension....Pages 313-320
Some Aspects of Cardiovascular Nervous Control in Spontaneously Hypertensive Rats: Central and Peripheral Mechanisms....Pages 321-333
Pre- and Postsynaptic Receptors in Hypertensive States....Pages 334-352
Electrical Events of Vascular Smooth Muscle in Response to α 1 -Adrenoceptor Stimulation....Pages 353-362
Introduction....Pages 363-363
Studies of Renin Biosynthesis and Release....Pages 365-375
Molecular Cloning of Submaxillary Renin cDNA....Pages 376-380
Primary Structure of Mouse Submaxillary Gland Renin....Pages 381-388
Purification of Prorenin....Pages 389-406
Extrarenal Renin-Angiotensin System: Comments on its Occurrence and Cardiovascular Role....Pages 407-418
Studies on the Purification and Characterization of Human Angiotensinogen....Pages 419-429
Enzymatic Studies with Renin Substrate....Pages 430-439
The Brain Renin-Angiotensin System: Problems and Answers....Pages 440-458
Introduction....Pages 459-459
A Bipolar Analysis of Blood Pressure Phenomena: The Vasoconstriction and Volume Factors in Normotension and in the Spectrum of Hypertensive Disorders as Revealed by Renin-Sodium Profiling or Pharmacologic Probes; Prorenin as a Determinant of Renin Secretion....Pages 461-485
Regulation of Blood Pressure by Vasopressin....Pages 486-499
The Renomedullary Interstitial Cells in Hypertension....Pages 500-507
The Pituitary and Hypertension....Pages 508-519
Stress, Acth, and Hypertension....Pages 520-530
Mineralocorticoids in Hypertension: 19-Nor-Corticosteroids in Experimental and Human Hypertension....Pages 531-542
Renal and CNS Factors in NaCl-Induced Hypertension....Pages 543-557