Topics in Applied Statistics: 2012 Symposium of the International Chinese Statistical Association

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Constructing and Evaluating an Autoregressive House Price Index....Pages 3-12
On Portfolio Allocation: A Comparison of Using Low-Frequency and High-Frequency Financial Data....Pages 13-22
Applications of Functional Dynamic Factor Models....Pages 23-37
Mixed Modeling for Physician-Direct Campaigns....Pages 39-47
Uplift Modeling Application and Methodology in Database Marketing....Pages 49-60
Front Matter....Pages 61-61
Designing Studies for Assessing Efficacy in Mixture Populations....Pages 63-73
Estimating Subject-Specific Treatment Differences for Risk-Benefit Assessment with Applications to Beta-Blocker Effectiveness Trials....Pages 75-86
Missing Data in Principal Surrogacy Settings....Pages 87-97
Assessment of Treatment-Mediated Correlation Between a Clinical Endpoint and a Biomarker....Pages 99-110
Biomarker Selection in Medical Diagnosis....Pages 111-121
Front Matter....Pages 123-123
Safety Concerns of the 3+3 Design: A Comparison to the mTPI Design....Pages 125-135
Bayesian Interim Inference of Probability of Clinical Trial Success....Pages 137-147
Bayesian Survival Analysis Using Log-Linear Median Regression Models....Pages 149-158
Bayesian Analysis of Survival Data with Semi-competing Risks and Treatment Switching....Pages 159-169
Front Matter....Pages 171-171
High-Dimensional Ordinary Differential Equation Models for Reconstructing Genome-Wide Dynamic Regulatory Networks....Pages 173-190
Kernel Methods for Regression Analysis of Microbiome Compositional Data....Pages 191-201
A Conditional Autoregressive Model for Detecting Natural Selection in Protein-Coding DNA Sequences....Pages 203-212
Dimension Reduction for Tensor Classification....Pages 213-227
Successive Standardization: Application to Case-Control Studies....Pages 229-239
Front Matter....Pages 241-241
Quantification of PFS Effect for Accelerated Approval of Oncology Drugs....Pages 243-256
Front Matter....Pages 241-241
Integrative Analysis of Multiple Cancer Prognosis Datasets Under the Heterogeneity Model....Pages 257-269
Front Matter....Pages 271-271
On Analysis of Low Incidence Adverse Events in Clinical Trials....Pages 273-282
Statistical Power to Detect Cardiovascular Signals in First-in-Human Trials: Is It Really Small?....Pages 283-295
Front Matter....Pages 297-297
Constructing Conditional Reference Charts for Grip Strength Measured with Error....Pages 299-310
Hierarchical Bayesian Analysis of Repeated Binary Data with Missing Covariates....Pages 311-322
Front Matter....Pages 323-323
Use of Random Effect Models in the Design and Analysis of Multi-regional Clinical Trials....Pages 325-334
Front Matter....Pages 335-335
Experimental Design for In Vitro Drug Combination Studies....Pages 337-344