Thyroid Cancer: A Comprehensive Guide to Clinical Management

Front Matter....Pages i-xxxi
Front Matter....Pages 1-1
Anatomy and Physiology of the Thyroid Gland: Clinical Correlates to Thyroid Cancer....Pages 3-8
Epidemiology of Thyroid Cancer....Pages 9-15
Molecular Pathogenesis of Thyroid Cancer and Oncogenes in Thyroid Cancer....Pages 17-30
Molecular Aspects of Thyroid Cancer in Children....Pages 31-41
The Role of Genetics in the Development of Familial Nonmedullary Thyroid Cancer....Pages 43-70
Apoptosis in Thyroid Cancer....Pages 71-77
Radiation-Induced Thyroid Cancer....Pages 79-100
Classification of Thyroid Malignancies....Pages 101-104
Staging of Thyroid Cancer....Pages 105-117
Recombinant Human Thyrotropin....Pages 119-129
Front Matter....Pages 131-131
Radioiodine Whole-Body Imaging....Pages 133-152
Primer and Atlas for the Interpretation of Radioiodine Whole Body Scintigraphy....Pages 153-184
False-Positive Radioiodine Scans in Thyroid Cancer....Pages 185-204
The Utility of SPECT-CT in Differentiated Thyroid Cancer....Pages 205-214
Radioiodine Scintigraphy with SPECT/CT: An Important Diagnostic Tool for Staging and Risk Stratification....Pages 215-223
Stunning by 131I Scanning: Untoward Effect of 131I Thyroid Imaging Prior to Radioablation Therapy....Pages 225-235
Stunning Is Not a Problem....Pages 237-241
Stunning: Does It Exist? A Commentary....Pages 243-244
To Perform or Not to Perform Radioiodine Scans Prior to 131I Remnant Ablation? PRO....Pages 245-254
Front Matter....Pages 255-255
The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management....Pages 257-275
Front Matter....Pages 255-255
Fine-Needle Aspiration....Pages 277-280
Diagnostic and Prognostic Molecular Markers in Thyroid Cancer....Pages 281-292
Ultrasonic Imaging of the Thyroid Gland....Pages 293-314
Radionuclide Imaging of Thyroid Nodules....Pages 315-322
Thyroid Nodules and Cancer Risk: Surgical Management....Pages 323-330
Thyroid Nodules in Children and Cancer Risk....Pages 331-333
Management of the Thyroid Nodule: A Comparison of Published International Guidelines....Pages 335-346
Front Matter....Pages 347-355
Papillary Carcinoma: Clinical Aspects....Pages 357-357
Papillary Microcarcinoma....Pages 359-370
Surgical Approach to Papillary Thyroid Cancer....Pages 371-376
Papillary Carcinoma: Cytology and Pathology....Pages 377-379
Front Matter....Pages 381-391
Remnant Ablation, Adjuvant Treatment and Treatment of Locoregional Metastases with 131I....Pages 393-393
Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin....Pages 395-409
Front Matter....Pages 411-416
Follow-Up Strategy in Papillary Thyroid Cancer....Pages 417-417
Thyroid Hormone Therapy and Thyrotropin Suppression....Pages 419-425
Thyroglobulin for Differentiated Thyroid Cancer: Measurement and Interferences....Pages 427-432
Thyroglobulin Antibodies and Their Measurement....Pages 433-442
Diagnosis of Recurrent Thyroid Cancer in Patients with Anti-thyroglobulin Antibodies....Pages 443-447
Ultrasound of the Neck Lymph Nodes....Pages 449-454
Front Matter....Pages 455-470
Surveillance Radioiodine Whole Body Scans....Pages 417-417
Radionuclide Imaging and Treatment of Children with Thyroid Cancer....Pages 471-473
Positron Emission Tomography-Computed Tomography (PET-CT and PET) in Well-Differentiated Thyroid Cancer....Pages 475-485
Alternative Thyroid Imaging....Pages 487-504
MR and CT Imaging of Thyroid Cancer....Pages 505-513
Thyroglobulin in Lymph Node Aspirate....Pages 515-524
Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin....Pages 525-528
Prognosis in Papillary Thyroid Cancer....Pages 529-538
Surgical Management of Lymph Node Metastases....Pages 539-542
Utility of Second Surgery for Lymph Node Metastases....Pages 543-544
Papillary Cancer: Special Aspects in Children....Pages 545-550
Special Presentations of Thyroid Cancer in Thyrotoxicosis, Renal Failure, and Struma Ovarii....Pages 551-563
Thyroglossal Duct Carcinoma....Pages 565-568
Thyroid Cancer in Pregnancy....Pages 569-572
Front Matter....Pages 573-582
Radiation and Radioactivity....Pages 583-583
Treatment of Metastatic Thyroid Cancer with Radioiodine Following Preparation by Recombinant Human Thyrotropin....Pages 585-593
Dosimetrically Determined Prescribed Activity of 131I for the Treatment of Metastatic Differentiated Thyroid Carcinoma....Pages 595-627
Simplified Methods of Dosimetry....Pages 629-634
Radioiodine Dosimetry with Recombinant Human Thyrotropin....Pages 635-650
Front Matter....Pages 651-656
The Use of Lithium as an Adjuvant to Radioiodine in the Treatment of Thyroid Cancer....Pages 657-664
Side Effects of 131I for Therapy of Differentiated Thyroid Carcinoma....Pages 583-583
External Radiation Therapy for Papillary Carcinoma....Pages 665-669
Chemotherapy of Thyroid Cancer: General Principles....Pages 671-708
Bone Metastases from Differentiated Thyroid Carcinoma....Pages 709-715
A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer....Pages 717-721
Adjunctive Local Approaches to Thyroid Nodules and Metastatic Thyroid Cancer....Pages 723-733
Radioiodine-Refractory Thyroid Cancer: Restoring Response to Radioiodine Therapy....Pages 735-744
Alternative and Complementary Treatment of Thyroid Disorders....Pages 745-750
Front Matter....Pages 751-758
Follicular Thyroid Carcinoma....Pages 759-765
Surgical Management of Follicular Cancer....Pages 767-767
Pathology of Follicular Cancer....Pages 769-778
Hürthle Cell Carcinoma....Pages 779-780
Follow-Up Strategy in Follicular Thyroid Cancer....Pages 781-786
Radionuclide Imaging and 131I Therapy in Follicular Thyroid Carcinoma....Pages 787-791
PET/CT in Follicular Cancer Including Hürthle Cell Cancer....Pages 793-796
Follicular Thyroid Cancer: Special Aspects in Children and Adolescents....Pages 797-798
External Radiation Therapy for Follicular Carcinoma....Pages 799-800
Determinants of Prognosis of Follicular Thyroid Carcinoma....Pages 801-805
Front Matter....Pages 807-810
Aggressive Variants of Papillary Thyroid Carcinoma and Poorly Differentiated Carcinoma....Pages 811-813
Front Matter....Pages 815-815
Miscellaneous and Unusual Tumors of the Thyroid Gland....Pages 817-823
Pathology of Miscellaneous and Unusual Cancers of the Thyroid....Pages 815-815
Front Matter....Pages 825-843
Clinical Aspects of Medullary Thyroid Carcinoma....Pages 845-849
Cytology and Pathology of Medullary Thyroid Cancer....Pages 851-851
Medullary Carcinoma of the Thyroid: Surgical Management....Pages 853-863
Radionuclide Imaging of Medullary Carcinoma....Pages 865-869
PET/CT in Medullary Thyroid Cancer....Pages 871-872
External Radiation Therapy for Medullary Cancer....Pages 873-880
Medullary Carcinoma of the Thyroid: Chemotherapy....Pages 881-886
A Comparison of the ATA, NCCN, ETA, and BTA Guidelines for the Management of Medullary Thyroid Cancer....Pages 887-890
Front Matter....Pages 891-897
Thyroid Lymphoma....Pages 899-910
Pathology of Lymphoma of the Thyroid....Pages 911-911
PET/CT in Lymphoma and Lymphoma of the Thyroid....Pages 913-920
Front Matter....Pages 921-922
Anaplastic Thyroid Carcinoma: Clinical Aspects....Pages 923-926
Surgical Management of Anaplastic Thyroid Carcinoma....Pages 927-927
Pathology of Anaplastic Carcinoma....Pages 929-932
PET/CT in Anaplastic Cancer of the Thyroid....Pages 933-934
External Radiation Therapy for Anaplastic Thyroid Cancer....Pages 935-937
Chemotherapy for Anaplastic Thyroid Cancer....Pages 939-941
Anaplastic Thyroid Carcinoma: Prognosis....Pages 943-945
Front Matter....Pages 947-952
Advances in Radiation Therapy....Pages 953-956
New Approaches in Nuclear Medicine for Thyroid Cancer....Pages 957-957
Future Directions for Advanced Thyroid Cancer Therapy....Pages 959-962
Potential Approaches to Chemotherapy of Thyroid Cancer in the Future....Pages 963-971
Front Matter....Pages 973-989
Prophylaxis Against Radiation Exposure from Radioiodine....Pages 991-999
Low-Iodine Diets....Pages 1001-1006
Back Matter....Pages 1007-1007
....Pages 1009-1013