Thyroid Autoimmunity

Front Matter....Pages i-xvi
Graves’ Disease a Paradigm For Autoimmunity....Pages 1-10
Nature of Thyroid Autoantigens: The TSH Receptor....Pages 11-26
Progress in Understanding the Thyroid Microsomal Antigen....Pages 27-34
A Possible Role of Bacterial Antigens in the Pathogenesis of Autoimmune Thyroid Disease....Pages 35-44
“ATRA 1”: a New Autoantigen in Autoimmune Thyroid Disease....Pages 45-52
Monoclonal Antibodies in the Study of Thyriod Autoantigens and Autoantibodies....Pages 53-62
Lats/Tsab: Then And Now....Pages 63-68
Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease....Pages 69-76
Physiopathological Relevance of Thyroid Stimulating Antibody (TSAb) Measurements in Graves’ Disease....Pages 77-82
TSH Receptor Autoantibodies Affecting Thyroid Cell Function....Pages 83-90
Heterogeneity of TSH Receptor-directed Antibodies (TRAb) and Their Significance....Pages 91-98
Humoral Factors in Graves’ Ophthalmopathy....Pages 99-108
Immunoregulatory Abnormalities in Autoimmune Thyroid Disease....Pages 109-115
Intrathyroidal Lymphocytes, Thyroid Autoantibodies and Thyroid Destruction....Pages 117-124
Cellular Mechanism for Autoimmune Damage in Thyroid-Associated Ophthalmopathy....Pages 125-133
Thyroid Infiltrating T Lymphocytes in Hashimoto’s Thyroiditis: Phenotypic and Functional Analysis at Single Cell Level....Pages 135-144
An In Vitro Model for Thyroid Autoimmunity....Pages 145-152
Genetic Aspects Of Graves’disease....Pages 153-158
Thyroid and Related Autoimmune Disorders: Challenging the Dogmas....Pages 159-173
Molecular and Functional Characterization of Genes Encoding Anti-Thyroglobulin and Anti-Tsh Receptor Antibodies....Pages 175-180
Autoantigenicity of Murine Thyroglobulin....Pages 181-187
Igg Subclass Distribution of Anti-Tg Antibodies Among Thyroid Disease Patients and Their Relatives and in High and Low Responder Mouse Strains....Pages 189-198
Genetic Basis of Spontaneous Autoimmune Thyroiditis....Pages 199-206
Heterotransplantation of Autoimmune Human Thyroid to Nude Mice as a Tool for in Vivo Autoimmune Research....Pages 207-210
Post-Partum Thyroid Dysfunction....Pages 211-219
Autoimmune and Autonomous Toxic Goiter: Differentation and Clinical Outcome After Drug Treatment....Pages 221-230
Postpartum Onset Of Graves’ Disease....Pages 231-240
Thyrotropin-Binding Inhibitor Immunoglobulins in Primary Hypothyroidism....Pages 241-248
Thyroid Function Modulates Thymic Endocrine Activity....Pages 249-256
The Bb/W Rat, A Model For “Tgi-Associated Goitre”....Pages 257-262
Non-Thyroidal Complications of Graves’ Disease: Perspective On Pathogenesis And Treatment....Pages 263-269
Cross-Reactivity Between Antibodies to Human Thyroglobulin and Torpedo Acetylcholinesterase in Patients With Graves’ Ophthalmopathy....Pages 271-273
Multiple Autoantigenic Determinants in Thyroid Autoimmunity....Pages 275-277
Further Characterization of the Thyroid Microsomal Antigen by Monoclonal Antibodies....Pages 279-281
Molecular Cloning of a Thyroid Peroxidase cDNA Fragment Encoding Epitopes Involved in Hashimoto’s Thyroiditis [HT]....Pages 283-284
Further Evidence that Thyroid Peroxidase and the “Microsomal Antigen” are the Same Entity....Pages 285-288
Competitive and Immunometric Radioassays for the Measurement of Anti-Thyroid Peroxidase Autoantibodies in Human Sera....Pages 289-291
Thyroid Peroxidase and the “Microsomal Antigen” Cannot be Distinguished by Immunofluorescence on Cultured Thyroid Cells....Pages 293-295
Measurement of Anti-α-Galactosyl Antibodies in the Course of Various Thyroid Disorders and Isolation of an Antigenic Glycopeptide Fraction....Pages 297-299
The IgG Subclass Distribution Of Thyroid Autoantibodies In Graves’ Disease....Pages 301-303
Thyroid Hormone Binding Autoantibodies (Thba) in Humans and Animals....Pages 305-307
High Frequency of Interferon-γ Producing T Cells In Thyroid Infiltrates of Patients With Hashimoto’s Thyroiditis....Pages 309-312
Lymphokine Production and Functional Activities of T Cell Clones From Thyroid Gland of Hashimoto’s Thyroiditis....Pages 313-314
Circulatory Thyroglobulin Threshold in Suppressor Activation....Pages 315-317
Thyroglobulin Autoantibody IgG Subclasses; Regulation By T Cells....Pages 319-321
Cellular Immunity and Specific Defects of T-Cell Suppression in Patients With Autoimmune Thyroid Disorders....Pages 323-325
The Influence of Interleukin-1 on The Function of Human Thyroid Cells....Pages 327-329
Immunohistochemical Characterisation of Lymphocytes in Experimental Autoimmune Thyroiditis....Pages 331-334
λ Light Chain Restriction in the Diffuse Thyroid Lymphoid Infiltrate in Untreated Graves’disease....Pages 335-337
Natural Killer Cell Activity in Hashimoto, Graves’ Disease and Euthyroid Exophthalmos....Pages 339-341
Interaction of Purified Graves’ Immunoglobulins with the TSH-Receptor....Pages 343-345
Thyroid Stimulating Immunoglobulins without Evidence of in Vivo Thyroid Stimulation in Some Non-Thyroid Autoimmune Diseases....Pages 347-350
The Effect of Thyroid Stimulating Immunoglobulins (TSI) on Thyroid Camp: Comparison with TSH Activity....Pages 351-354
Proliferation in Cultivated Follicles of Graves’ Thyroids: Immunohistochemical Studies with Antibody KI-67....Pages 355-357
The Significance of Immunoglobulins Related to Stimulation of Thyroid Growth in Patients with Endemic Goiter....Pages 359-362
Regulation of Growth of Thyroid Cells in Culture by TSH Receptor Antibodies and Other Humoral Factors....Pages 363-365
Polyamine Modulation of Responses to Graves’IgG in Guinea Pig and Human Thyroid....Pages 367-369
Evidence For Intrathyroidal Production of Thyroid Growth-Stimulating Immunoglobulins....Pages 371-373
Presence of Thyroid Growth Promoting Antibody in Patients With Graves’ Disease in Remission: Medical versus Surgical Therapy....Pages 375-377
Thyrotrophin and Growth Promoting Immunoglobulin(TGI) of FRTL-5 Cells Have No Growth Stimulating Activity on Human Thyroid Epithelial Cell Cultures....Pages 379-384
Autoantibodies Stimulating Thyroid Growth and Adenylate Cyclase Cannot be Separated in IgGs From Patients with Active Graves’ Disease....Pages 385-387
Antiidiotypic Blocking of Graves′ Disease Biologic Activity with Autologous Sera But Not Consistently with Homologous Sera: Evidence for Polyclonality of Thyroid Receptor Antibodies (Trab)....Pages 389-392
Autoantibodies Blocking the TSH-Induced Adenylate Cyclase Stimulation in Idiopathic Myxedema and Hashimoto’s Thyroiditis....Pages 393-395
Relevance of Maternal Thyroid Autoantibodies on the Development of Congenital Hypothyroidism....Pages 397-399
Ability of Immunoglobulins From Patients With Thyroid Disease to Stimulate Skin Fibroblasts....Pages 401-403
Some Evidences that Thyrotropin and Autoantibodies Binding Sites are Located on Different Polipeptide Chains of Thyroid Plasma Membrane Proteins....Pages 405-408
Presence of Thyroid Growth Promoting Antibody in Patients With Hashimoto’s Thyroiditis: Effect of Long-Term Thyroxine Treatment....Pages 409-412
Limited Clinical Value of TBII and TSAB for Prediction of the Outcome of Patients with Graves’ Disease....Pages 413-415
TSH Receptor Antibodies in Neonatal Hyperthyroidism....Pages 417-419
Thyroid Autoimmunity as a Major Cause for Congenital Hypothyroidism....Pages 421-424
Thyroid Growth Blocking Antibodies in Congenital Hypothyroidism....Pages 425-427
Incidence of TSH Receptor Antibodies in Patients with Toxic Diffuse....Pages 429-431
Blocking-Antibodies Apparently Without Any Stimulatory Activity are Present in Sera of Patients with Graves’ Disease....Pages 433-435
Increased Frequency of HLA-DR5 in Metro Toronto Patients with Goitrous Autoimmune Thyroiditis and Post-Partum Thyroiditis....Pages 437-440
Post-Partum Thyroid Dysfunction and HLA Status....Pages 441-443
Methimazole, γ-”Interferon and Graves′ Disease....Pages 445-447
The Prognostic Value of Combined Measurement Of Thyroid-Stimulating Antibody and Serum Thyroglobulin Levels During Graves′ Disease Long Term Thionamide Treatment....Pages 449-452
Serum Thyroid Autoantibodies in a Long-Term Study of Thyrostatic Treatment of Graves’ Disease....Pages 453-456
The Effect of High Doses of Carbimazole in Patients with Graves’disease and in Subjects with Thyroid Antibodies....Pages 457-459
Thymulin Deficiency and Low T3 Syndrome in Infants With Low-Birth-Weight Syndromes....Pages 461-463
Constitutive Expression of HLA Class II Molecules in Human Thyroid Cells Transfected with SV-40....Pages 465-467
Specific DNA Polymorphisms in the DQ Alpha Region of Patients with Graves’ Disease and Hashimoto’s Thyroiditis....Pages 469-471
Survey of Post-Partum Thyroid Antimicrosomal Autoantibody as a Marker for Thyroid Dysfunction....Pages 473-475
HLA Region Gene Involvement in Congenital Hypothyroidism....Pages 477-479
Probability of a Beneficial, Dose-Dependent, Immunosuppressive Action of Carbimazole in Graves’ Disease....Pages 481-483
Evidence for Dr-Ag-Expression by Rhs-Cells and not by Epithelial Cells....Pages 485-487
HLA-Dr- β Gene Analysis in Patients with Braues’ Disease....Pages 489-491
Immune Signals Fail to Elict Endocrine Responses in the Obese Strain (OS) of Chickens with Hashimoto-Like Autoimmune Thyroiditis....Pages 493-495
Inappropriate HLA Class II Expression in a Wide Variety of Thyroid Diseases....Pages 497-500
Adverse Reactions Related to Methimazole and Propylthiouracil Doses....Pages 501-503
Thyroid Suppressibility in Graves’ Disease: Relationship with Thyroid Stimulating Antibody and Serum Thyroglobulin Levels....Pages 505-508
Influence of Lymphokines and Thyroid Hormones on Natural Killer Activity....Pages 509-511
Results of Thyrostatic Drug Treatment in Hyperthyroidism a Clinical Long-Term Study....Pages 513-515
Predictive Use of Tsh-Receptor Antibodies Assay as a Prognostic Index in Graves’ Patients Treated with Antithyroid Drugs or Radioactive-Iodine....Pages 517-519
Affinity Purification of Orbital Antigens Using Human Monoclonal Antibodies in Graves’ Ophthalmopathy....Pages 521-524
The Exophthalmos-Related Eye Muscle Antigens are not Related To Thyroid Antigens: Lack of Binding Inhibition Using Thyroid Microsomes and Thyreoglobulin....Pages 525-527
Humoral Immunity in Graves Ophthalmopathy....Pages 529-531
Autoantibodies of IgM and IgG Class Against Eye Muscle Antigens in Patients with Graves Ophthalmopathy....Pages 533-535
Endocrine Exophthalmos - Natural History and Results of Treatment....Pages 537-539
Immunosuppressive Treatment of Graves’ Ophthalmopathy with Ophthalmopathy with Cyclosporin A and Ciamexon....Pages 541-543
Treatment of Graves’ Ophthalmopathy by Retrobulbar Corticosteroids Associated With Orbital Cobalt Radiotherapy....Pages 545-547
Immunological Features of Simple Endemic Goitre....Pages 549-550
Thyroid Autoimmunity in Five Samples of General Population in Italy....Pages 551-553
Prevalence of Hypothyroidism and Hashimoto’s Thyroiditis in Two Elderly Populations with Different Dietary Iodine Intake....Pages 555-557
Evidence of The Influence of Iodine Intake on The Prevalence of Autoimmune Factors in Hyperthyroid Patients Living in an Endemic Goitre Area....Pages 559-562
Further Data on Iodine-Induced Autoimmunity....Pages 563-565
Study of Class I and Class II Antigen Expression and Lymphocytic Infiltrate on Thyroid Tumors....Pages 567-569
Incidence of Anti-Thyroid Autoantibodies in Thyroid Cancer Patients....Pages 571-573
Thyroid Autoantibodies in Thyroid Cancer....Pages 575-577
Some Aspects of Cell Mediated Autoimmunity in Endemic Nodular Goitre....Pages 579-581
Chronic Lymphocytic Thyroiditis in Endemic Goiter: Local Ig Production and Deposition....Pages 583-586
Autoimmune Thyroid Disease in The City of Graves....Pages 587-589
A Retrospective Study of Thyroid Autoimmunity and Hypothyroit Dism in a Random Obese Population....Pages 591-593
Circulating Thyroid Autoantibodies in Children and Youngsters with Insulin Dependent Diabetes Mellitus (IDDM) are Not Predictive of Overt Autoimmune Thyroid Disease....Pages 595-597
Effects of Chronic Amiodarone Administration on Humoral Thyroid Autoimmunity....Pages 599-601
Serum Thyroid Autoantibodies in Patients with Breast Cancer....Pages 603-605
Complement Activities and Circulating Immune Complexes in Sera of Patients With Graves′ Disease and Hashimotofs Thyroiditis....Pages 607-609
Abnormalities of Thyroid Function in Sjogren’s Syndrome....Pages 611-613
Thyroid and Renal Amyloidosis in Thyroglobulin Immunized Rabbits....Pages 615-617
Absence of Thyroglobulin in Kidney of Patients with Autoimmune Thyroiditis and Nephropathies....Pages 619-621
Persistence of Autoimmune Reactions During Recovery of Subacute Thyroiditis....Pages 623-625
Purified Protein Derivative Reaction and Urinary Immunosuppressive Acidic Protein in Patients With Subacute Thyroiditis....Pages 627-629
Interferences of Circulating Anti-TSH Antibodies in Methods for Thyrotropin Measurement....Pages 631-634
Back Matter....Pages 635-638