Thymic Hormones and Lymphokines: Basic Chemistry and Clinical Applications

Front Matter....Pages i-xiii
Human T-Cell Growth Factor, Growth of Human Neoplastic T Cells, and Human T-Cell Leukemia-Lymphoma Virus....Pages 1-17
Front Matter....Pages 19-19
Thymosins....Pages 21-35
Thymulin....Pages 37-42
Use of Monoclonal Antibodies to Identify Antigens of Human Endocrine Thymic Epithelium....Pages 43-56
Abnormal Levels of Thymosin α 1 and the Destruction of the Thymus Gland in the Acquired Immune Deficiency Syndrome....Pages 57-60
Thymic Epithelial Injury in the Acquired Immune Deficiency Syndrome....Pages 61-67
Increased Thymosin Levels Associated with Acquired Immune Deficiency Syndrome....Pages 69-76
Thymosin β 4 ....Pages 77-88
The Finding and Significance of Spermidine and Spermine in Thymic Tissue and Extracts....Pages 89-95
Synthetic Small Thymic Peptides....Pages 97-109
Human Peripheral Blood Lymphocytes Bear Markers for Thymosins (α 1 , α 7 , β 4 )....Pages 111-117
Thymosin β 4 Is Present in a Subset of Oligodendrocytes in the Normal Human Brain....Pages 119-125
The Synthesis and Physical Properties of Thymosin α 1 and Its Analogs Prepared by Fragment Condensation....Pages 127-134
Immunocytochemical Localization of Thymosin and Thymopoietin in Human, Rat, and Murine Thymus....Pages 135-143
Thymus- and Spleen-Derived Immunosuppressive Peptides....Pages 145-154
Production of a Thymosin α 1 -like Material by T-Cell Lymphomas....Pages 155-163
Purification and Characterization of an Immunoreactive Thymosin α 1 from Human Blood....Pages 165-173
Front Matter....Pages 179-179
Characterization of Immunoaffinity-Purified Human T-Cell Growth Factor from JURKAT Cells....Pages 181-189
The Use of Lymphoid Cells Expanded in IL-2 for the Adoptive Immunotherapy of Murine and Human Tumors....Pages 191-207
Biochemical and Biological Properties of Interleukin-3....Pages 209-222
Front Matter....Pages 179-179
Lymphotoxins, a Multicomponent Family of Effector Molecules....Pages 223-233
Chemical and Biological Properties of Human Lymphotoxin....Pages 235-245
T-Cell Growth Factor....Pages 247-256
Demonstration and Characterization of Human Intracellular Interleukin-1....Pages 257-264
Silicic Acid Batch Adsorption Procedure for the Partial Purification of Interleukin-2 from Cultures of Primary Lymphocytes and Long-Term T-Cell Lines....Pages 265-272
TCGF (IL-2) Receptor (Tac Antigen) on ATL and Non-ATL Leukemic Cells....Pages 273-277
Front Matter....Pages 283-283
Lymphocyte Proliferation, Lymphokine Production, and Lymphocyte Receptors in Aging....Pages 285-295
Augmentation of Antibody Synthesis in Vitro by Thymosin Fraction 5....Pages 297-305
The Production and Characterization of Monoclonal Antibodies to Lymphokines....Pages 307-312
Modulatory Interactions between the Central Nervous System and the Immune System....Pages 313-323
Effects of Thymic Peptides on Hypothalamic-Pituitary Function....Pages 325-334
Biochemistry of Lymphokine Action on Macrophages....Pages 335-346
Modulation of Macrophage Phenotypes by Migration Inhibitory Factors....Pages 347-355
The Anticancer Action of Lymphotoxin....Pages 357-364
Pituitary Responses to Acute Administration of Thymosin and to Thymectomy in Prepubertal Primates....Pages 365-374
Expression of T-Cell Markers on Chicken Bone Marrow Precursor Cells Incubated with an Avian Thymic Hormone....Pages 375-382
Transferrin Receptor Induction in Mitogen-Stimulated Human T Lymphocytes Is Required for DNA Synthesis and Cell Division and Is Regulated by Interleukin-2 (TCGF)....Pages 383-394
Front Matter....Pages 399-399
Phase I Trial of Intravenous Lymphokine MAF....Pages 401-412
Interaction of Thymic Hormones with Prostaglandins....Pages 413-419
A Small-Molecular-Weight Growth Inhibitory Factor (SGIF) in Stationary-Phase Supernatants of Tissue Cultures....Pages 421-423
Front Matter....Pages 399-399
Efficacy of Thymosin α 1 in Animal Models....Pages 425-438
The in Vivo Effect of Thymosin on Cell-Mediated Immunity....Pages 439-443
Effect of Thymosin α 1 on Immunoregulatory T Lymphocytes....Pages 445-453
Treatment of the Diabetic, Autoimmune db/db Mouse with Thymosin....Pages 455-461
Role of Thymosin Fraction 5 in Host Defenses to Leukemia in Nutritionally Stressed Mice....Pages 463-468
Tumor Growth, Interleukins, and Immune Complexes....Pages 469-474
Interleukin-3 Production and Action in Tumor-Bearing Hosts....Pages 475-481
Lymphokine-Mediated Enhancement of Antibody Formation by Leukemic Cells....Pages 483-488
Front Matter....Pages 495-495
A Phase I Trial of Immune Interferon....Pages 497-506
The Response of Tumor-Bearing Patients to the Injection of Lymphoid Cell Line Lymphokine....Pages 507-517
Clinical Studies of Lymphoid Cell Lymphokines in 102 Patients with Malignant Solid Tumors....Pages 519-524
Regulation of T-Cell Proliferation by Interleukin-2 in Male Homosexuals with Acquired Immune Deficiency Syndrome....Pages 525-529
Incorporation of Porcine Thymic Peptides into the Treatment of Fulminant Viral Hepatitis....Pages 531-540
Use of Porcine Thymic Immunomodulator in the Treatment of Chronic Hepatitis B....Pages 541-544
Biological Properties and Clinical Use of Calf Thymus Extract TFX-Polfa....Pages 545-564
Role of Thymostimulin (TP-1) as an Immunomodulator in Hodgkin’s Disease....Pages 565-570
Thymosin Fraction 5 Treatment of Patients with Cellular Immunodeficiency Disorders....Pages 571-577
Effect of Thymosin on in Vitro Immune Function in Patients with Rheumatoid Arthritis....Pages 579-585
Phase I Trial Using Thymosin Fraction 5 in Renal Cancer....Pages 587-591
Clinical Aspects of Thymulin (FTS)....Pages 593-600
Front Matter....Pages 495-495
An Evaluation of Two Different Schedules of Synthetic Thymosin α 1 Administration in Patients with Lung Cancer....Pages 601-613
Effect of Thymosin Fraction 5 on Purine Enzymes and Surface Markers in Lymphocytes from Normal Individuals and Homosexuals with Acquired Immune Deficiency Syndrome....Pages 615-621
Demonstration of a Block at an Early Stage of T-Cell Differentiation in Severe Combined Immunodeficiency Disease....Pages 623-628
Back Matter....Pages 637-669