Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Opening Lecture: What is Accomplished and What is Needed....Pages 3-21
Front Matter....Pages 23-23
New Anti-Virals Against Wild-Type and Lamivudine-Resistant Hepatitis B Virus....Pages 25-31
Lamivudine Therapy of Hepatitis B in Japan....Pages 32-37
Early Detection of Lamivudine Resistant Mutant in Chronic Hepatitis B Patients Using a Novel Sensitive Method....Pages 38-44
Front Matter....Pages 45-45
New Antiviral Treatment for Chronic Hepatitis B....Pages 47-56
New Antiviral Therapy: Adefovir Dipivoxil for HBV....Pages 57-62
Development of Entecavir: Superior Therapy for the Management of Chronic Hepatitis B Viral Infection....Pages 63-73
Front Matter....Pages 75-75
Therapy of Hepatitis B and Prevention of Hepatocellular Carcinoma....Pages 77-83
Differences of Clinical Characteristics Among Japanese Patients with Hepatitis B Virus Genotypes B and C....Pages 84-93
Front Matter....Pages 95-95
Establishment of a New Hepatitis C Virus-1 b Replicon....Pages 97-107
Hepatitis C Virus Replication in Cell Culture....Pages 108-122
Characterization of the Interferon Alpha Response Against HCV in Hepatoma Cells....Pages 123-130
Front Matter....Pages 131-131
Hepatitis C: Development of a Ribavirin Liver-Targeting Prodrug....Pages 133-139
HCV Replicon Inhibitors: Mode of Action and Resistance Mapping....Pages 140-154
Front Matter....Pages 155-155
Interferon Treatment Not Only Reduces the Risk of Hepatocellular Carcinoma But Also Improves Mortality in Patients with Chronic Hepatitis C Showing Biochemical Response, Especially in Patients with Advanced Liver Fibrosis....Pages 157-166
Favorable Outcome of Patients with C-Viral Liver Disease Treated with Interferon....Pages 167-175
IFN Receptor and IFN Signals....Pages 176-185
Front Matter....Pages 187-187
Management and Treatment of Hepatitis C....Pages 189-198
Hepatitis C Virus and Hepatocellular Carcinoma....Pages 199-208
Randomized Trial of Post-Operative Interferon Therapy After Resection of Hepatitis C Virus-Related Hepatocellular Carcinoma and Long-Term Outcome....Pages 209-218
Front Matter....Pages 187-187
Roles of Antiviral Therapy in Chronic Hepatitis C Patients Should be Different According to the Stages of Liver Disease Progression....Pages 219-228
Significance of Sustained Inflammation in the Development of HCC from HCV-Associated Cirrhotic Patients and the Prevention of HCC by Anti-Inflammatory Agents....Pages 229-237
Front Matter....Pages 239-239
Chemoprevention of Hepatocellular Carcinoma with Retinoid....Pages 241-248
Vitamin K 2 Administration Improves the Prognoses of Patients with Hepatocellular Carcinoma Presenting High Levels of Serum Des-γ-Carboxy Prothrombin....Pages 249-250
Combination Chemotherapy for Advanced Hepatocellular Carcinoma....Pages 251-257
Combined Intra-Arterial 5-Fluorouracil and Subcutaneous Interferon-Alpha Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombi in the Major Portal Branches....Pages 258-269
Front Matter....Pages 271-271
Liver Transplantation for Hepatitis B Virus-Related Liver Disease....Pages 273-282
Living Donor Liver Transplantation for Hepatitis B and C Cirrhosis....Pages 283-292
Living Donor Liver Transplantation for HBV-/HCV-Related Diseases....Pages 293-295