Therapeutic Monoclonal Antibodies

Front Matter....Pages i-xiii
The Use of In Vitro Immunization, Cloning of Variable Regions, and SCID Mice for the Production of Human Monoclonal Antibodies....Pages 1-15
Construction of Recombinant Therapeutic Monoclonal Antibodies....Pages 17-34
Antibody-Mediated Cancer Diagnosis and Therapy....Pages 35-56
Current Status and Future Perspectives of Chemoimmunoconjugates for the Treatment of Cancer....Pages 57-73
Gangliosides as Targets for Monoclonal Antibody Therapy of Cancer....Pages 75-94
Mouse Antibodies to Carcinomas....Pages 95-108
Therapeutic Implication of Monoclonal Antibodies against Multidrug-Resistant Tumor Cells....Pages 109-126
Radioimmunotherapy with 90Yttrium—Anti-Idiotype Monoclonal Antibody....Pages 127-141
Immunoconjugates of a Protein Synthesis-Inhibiting Drug....Pages 143-158
Human Monoclonal Anti-Idiotypic Antibodies against a Murine Monoclonal Antibody (Mab17-1A) as an Anti-Tumor Vaccine....Pages 159-171
Uses of Human Monoclonal Antibodies to Human Cytomegalovirus and Varicella-Zoster Virus....Pages 173-185
Development of a Human Monoclonal Antibody against Cytomegalovirus with the Aim of a Passive Immunotherapy....Pages 187-207
Characterization of Human Anti-Cytomegalovirus Monoclonal Antibodies....Pages 209-222
Immunoprotective Capacities of Human and Murine Monoclonal Antibodies Recognizing Serotype-Specific and Common Determinants of Gram-negative Bacteria....Pages 223-234
Preclinical Development of Xomen™-E5....Pages 235-251
Randomized Placebo-controlled Study of E5 Monoclonal Antiendotoxin Antibody....Pages 253-261
Human Monoclonal Antibodies against Human Red Blood Cells....Pages 263-286
CD7 Monoclonal Antibodies....Pages 287-302
Large-Scale Production of Monoclonal Antibodies....Pages 303-319
Therapeutic Monoclonal Antibodies: European Regulatory Issues....Pages 321-361
Back Matter....Pages 363-369