The Transplantation and Replacement of Thoracic Organs: The Present Status of Biological and Mechanical Replacement of the Heart and Lungs

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Experimental Development and Early Clinical Experience....Pages 3-10
Indications, Selection and Management of the Recipient....Pages 11-17
The Concept and Diagnosis of Brain Death....Pages 19-25
Medico-legal Aspects....Pages 27-32
Donor Organ Availability and Transplant Coordination....Pages 33-40
Selection and Management of the Donor....Pages 41-49
Storage of the Donor Heart....Pages 51-61
Pretransplant Immunological Considerations....Pages 63-70
Anesthetic Management Including Cardiopulmonary Bypass....Pages 71-73
Surgical Technique of Orthotopic Heart Transplantation....Pages 75-80
Surgical Technique of Heterotopic Heart Transplantation....Pages 81-87
Immediate Postoperative Care and Maintenance Immunosuppressive Therapy....Pages 89-99
Physiology and Pharmacology of the Transplanted Heart....Pages 101-108
Immunobiology of Allograft Destruction....Pages 109-114
Pathology of Acute Rejection....Pages 115-125
Diagnosis and Management of Acute Rejection....Pages 127-142
Infectious Complications....Pages 143-160
Pathology of Graft Atherosclerosis (Chronic Rejection)....Pages 161-167
Diagnosis and Management of Graft Atherosclerosis (Chronic Rejection)....Pages 169-175
Retransplantation....Pages 177-182
Front Matter....Pages 1-1
Malignant Neoplasia in the Immunocompromised Patient....Pages 183-190
Other Complications of Transplantation and Immunosuppressive Therapy....Pages 191-202
Heterotopic Heart Transplantation — Indications and Special Considerations....Pages 203-207
Heart Transplantation in Infants and Children — Indications and Special Considerations....Pages 209-216
Psychiatric Aspects....Pages 217-221
Medico-social Aspects....Pages 223-226
Nutrition and Diet....Pages 227-231
Exercise Rehabilitation....Pages 233-240
Non-cardiac Surgery in Patients with Heart Transplants — Anesthetic and Operative Considerations....Pages 241-244
Non-cardiac Autopsy Findings in Patients with Heart (or Heart—Lung) Transplants....Pages 245-250
Results of Cardiac Transplantation and Factors Influencing Survival....Pages 251-255
Results of Cardiac Transplantation and Factors Influencing Survival....Pages 257-258
Front Matter....Pages 259-259
Experimental Background and Early Clinical Experience....Pages 261-266
Indications, Selection, and Management of the Recipient....Pages 267-272
Selection of the Donor; Excision and Storage of Donor Organs....Pages 273-282
Anesthetic Management....Pages 283-287
Surgical Technique of the Recipient Operation....Pages 289-298
Postoperative Management, Surgical Complications, Diagnosis and Management of Acute Rejection....Pages 299-305
Immunological Aspects....Pages 307-314
Pathology of Heart—Lung Transplantation....Pages 315-324
Front Matter....Pages 259-259
Infectious Complications....Pages 325-332
Physiology and Pharmacology of the Transplanted Lungs....Pages 333-339
Diagnosis and Management of Bronchiolitis Obliterans (Chronic Rejection): Retransplantation....Pages 341-347
Results of Heart—Lung Transplantation and Factors Influencing Survival....Pages 349-353
Front Matter....Pages 355-355
Experimental Background and Early Clinical Experience....Pages 357-361
Indications, Selection and Management of the Recipient....Pages 363-368
Selection of the Donor: Excision and Storage of the Lungs....Pages 369-374
Anesthesia for Single Lung Transplantation....Pages 375-379
Surgical Technique of Single Lung Transplantation....Pages 381-383
Surgical Technique of Double Lung Transplantation....Pages 385-389
Postoperative Management....Pages 391-398
Complications....Pages 399-405
Results of Lung Transplantation....Pages 407-409
Front Matter....Pages 411-411
Indications and Selection of Cardiac Support Device....Pages 413-416
Non-pulsatile Centrifugal Pumps....Pages 417-421
Pulsatile Ventricular Assist Devices....Pages 423-430
Total Artificial Hearts....Pages 431-444
Results of Mechanical Circulatory Support as a ‘Bridge’ to Cardiac Transplantation — Combined Registry Report....Pages 445-449
Front Matter....Pages 451-451
Experimental Background and Current Problems....Pages 453-461
Clinical Experience....Pages 463-466
Front Matter....Pages 469-469
Xenotransplantation: Overview....Pages 471-477
Pathology of Xenograft Rejection....Pages 479-483
Mechanisms and Possible Management of Hyperacute (Vascular, Humoral) or Xenograft Rejection....Pages 485-492
Clinical Experience....Pages 493-494
Front Matter....Pages 495-495
Cardiomyoplasty....Pages 497-501
Blood Pumps Constructed from Skeletal Muscle....Pages 503-511
Front Matter....Pages 513-513
Some Ethical and Logistic Issues in Transplantation....Pages 515-522
Heart and Lung Replacement: Future Perspectives....Pages 523-533
Back Matter....Pages 535-543