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دانلود کتاب The Spectrum of Neuroendocrine Neoplasia: A Practical Approach to Diagnosis, Classification and Therapy
دانلود کتاب طیف نئوپلازی نورواندوکرین: رویکردی عملی برای تشخیص، طبقه‌بندی و درمان
مشخصات کتاب
The Spectrum of Neuroendocrine Neoplasia: A Practical Approach to Diagnosis, Classification and Therapy
ویرایش: نویسندگان: Sylvia L. Asa, Stefano La Rosa, Ozgur Mete سری: ISBN (شابک) : 9783030543907 ناشر: Springer سال نشر: 2020 تعداد صفحات: 478 [476] زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 45 Mb
قیمت کتاب (تومان) : 30,000
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توجه داشته باشید کتاب طیف نئوپلازی نورواندوکرین: رویکردی عملی برای تشخیص، طبقه‌بندی و درمان نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب طیف نئوپلازی نورواندوکرین: رویکردی عملی برای تشخیص، طبقه‌بندی و درمان
نئوپلاسم های نورواندوکرین خانواده بزرگی از ضایعات پرولیفراتیو را تشکیل می دهند که تقریباً هر قسمت از بدن را درگیر می کند. درک ما از سلول های منشأ آنها و همچنین آسیب شناسی، پاتوفیزیولوژی و ژنتیک این نئوپلاسم ها در چند دهه اخیر پیشرفت های شگرفی داشته است. در حالی که آنها اغلب به عنوان نهادهای جداگانه در کتاب های درسی آسیب شناسی گوارشی و پاتولوژی ریوی مورد بحث قرار می گیرند، دامنه آنها بسیار گسترده تر است. این کتاب شباهت‌ها و تفاوت‌های این تومورهای جذاب را که ممکن است از هیپوتالاموس و هیپوفیز تا رکتوم و در بافت نرم و همچنین در بسیاری از اندام‌ها یافت شود، بیان می‌کند. نوشته شده توسط متخصصان در این زمینه، نویسندگان بر ویژگی‌های ساختاری، عملکردی، پیش‌بینی‌کننده و پیش‌آگهی آنها تأکید می‌کنند و تلاش می‌کنند زمینه بالینی را فراهم کنند که امکان تشخیص و درمان را بهبود می‌بخشد و در عین حال بر اساس ژنتیکی که الگوهای وراثت و استعداد رشد تومور را از طریق ضایعات پیش‌ساز روشن می‌کند، ارائه می‌کنند. . طیف نئوپلازی نورواندوکرین با استفاده از رویکردی عملی برای تشخیص، طبقه‌بندی بافت‌شناسی و درمان، مروری کلی از نئوپلاسم‌های نورواندوکرین ارائه می‌کند و مهم‌ترین و مهم‌ترین پیشرفت‌های فناوری‌های مورد استفاده برای تشخیص، طبقه‌بندی و درمان آنها را ارائه می‌دهد.
توضیحاتی درمورد کتاب به خارجی
Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.
فهرست مطالب
Preface Contents Contributors 1: Neuroendocrine Neoplasms: Historical Background and Terminologies Introduction Neuroendocrine Tumors in the Ancient World The Scientific Revolution The Progress of Modern Science The Evolution of Definitions and Terminologies The Genetics of Neuroendocrine Neoplasia The Modern Approach to Neuroendocrine Tumors References 2: The Diagnosis of Neuroendocrine Neoplasms Introduction Gastroenteropancreatic and Lung Neuroendocrine Neoplasms Carcinoid Syndrome Hypoglycemia Zollinger-Ellison Syndrome Glucagonoma Syndrome Verner-Morrison Syndrome Somatostatinoma Syndrome Pheochromocytomas and Paragangliomas Medullary Thyroid Cancer Pituitary Neuroendocrine Tumors Hyperprolactinemia Cushing Syndrome Acromegaly Hyperthyroidism Parathyroid Adenoma and Carcinoma Summary References 3: Functional and Radiological Imaging of Neuroendocrine Neoplasms Introduction Lung Neuroendocrine Neoplasms Bronchial NEN General Considerations Radiological Imaging Nuclear Medicine Imaging Digestive NEN General Considerations Radiological Imaging Nuclear Medicine Imaging Pancreatic NEN General Considerations Radiological Imaging Nuclear Medicine Imaging Colorectal NEN General Considerations Radiological Imaging Nuclear Medicine Imaging Appendix NEN General Considerations Radiological and Nuclear Medicine Imaging Imaging of Rare Neuroendocrine Neoplasms General Considerations Characterization and Pre-therapeutic Staging General Considerations Radiological Imaging Nuclear Medicine and Theranostic Imaging References 4: Pituitary Neuroendocrine Neoplasms Historical Background Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 5: Hypothalamic Neuroendocrine Neoplasms Historical Background Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 6: Neuroendocrine Neoplasms of the Upper Aerodigestive Tract, Ear, and Salivary Glands Background Neoplasms of the Nasal Cavity and Paranasal Sinus Neuroendocrine Neoplasms of the Nasal Cavity Neuroendocrine Tumors (Carcinoids) Neuroendocrine Carcinoma Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) Olfactory Neuroblastoma Neuroendocrine Neoplasms of the Larynx Neuroendocrine Tumors (NETs, Carcinoids) NET G1 (Typical Carcinoid) NET G2 (Atypical Carcinoid) Neuroendocrine Carcinoma Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) Neuroendocrine Tumor of the Middle Ear Neuroendocrine Neoplasms of the Salivary Glands Neuroendocrine Tumors (NETs, Carcinoids) Neuroendocrine Carcinoma References 7: Thyroid Neuroendocrine Neoplasms Historical Background Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 8: Parathyroid Neuroendocrine Neoplasms Historical Background Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 9: Thoracic (Lung/Thymus) Neuroendocrine Neoplasms Foreword Classification of Thoracic NENs Lung Neuroendocrine Neoplasms Nonneoplastic Conditions and Preinvasive Lesions Neuroendocrine Cell Hyperplasia Clinical Features Pathology Tumorlets Clinical Features Pathology Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) Clinical Features Pathology Neuroendorine Tumors (Carcinoids) Epidemiology Gross, Clinical Presentation and Imaging Histopathology Carcinoid Variants Immunohistochemical Profile Evidence-Based Grading Proposals Large Cell Neuroendocrine Carcinoma Epidemiology Gross, Clinical Presentation and Imaging Histopathology Immunohistochemical Profile Small Cell Carcinoma Epidemiology Gross, Clinical Presentation and Imaging Histopathology Immunohistochemical Profile Combined Neuroendocrine-Non-neuroendocrine Carcinoma Thymic Neuroendocrine Neoplasms (T-NENs) Epidemiology Gross, Clinical Presentation and Imaging Histopathology Immunohistochemical Profile Origin of T-NENs and Combined Tumors Molecular Pathology Inheritance Molecular Classification Novel Insights on the Molecular Pathways of Progression References 10: Neuroendocrine Neoplasms of the Gut Background Neuroendocrine Neoplasms of the Esophagus Esophageal Neuroendocrine Tumor (NET) Esophageal Neuroendocrine Carcinoma (NEC) Esophageal Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Neuroendocrine Neoplasms of the Stomach Gastric Neuroendocrine Tumors (NETs) ECL-Cell NETs Type 1 ECL-Cell NET Type 2 ECL-Cell NET Type 3 NET Type 4 ECL-Cell NET G-Cell and D-Cell NETs EC-Cell NET Gastric Neuroendocrine Carcinoma (NEC) Gastric Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Neuroendocrine Neoplasms of the Duodenum Duodenal Neuroendocrine Tumors (NETs) Duodenal Gastrinoma Somatostatin-Producing D-Cell NETs Nonfunctioning NETs Gangliocytic Paraganglioma Duodenal Neuroendocrine Carcinoma (NEC) Duodenal Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Neuroendocrine Neoplasms of the Lower Jejunum, Ileum, and Right Colon Ileal and Lower Jejunal Neuroendocrine Tumors (NETs) Ileal and Lower Jejunal NEC and MiNEN Neuroendocrine Neoplasms of the Appendix Appendiceal Neuroendocrine Tumors (NETs) Appendiceal NECs and MiNENs Neuroendocrine Neoplasms of the Rectum Rectal Neuroendocrine Tumors (NETs) Rectal NECs and MiNENs References 11: Pancreatic Neuroendocrine Neoplasms Historical Background Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 12: Paragangliomas and Pheochromocytomas Historical Background Anatomy and Embryology Epidemiology Tumor Classification and Morphology Molecular Pathogenesis Prognosis References 13: Neuroendocrine Neoplasms of the Breast Background The History of Br-NEN Concept: An Unclosed Circle Br-NENs: Who’s Who? Neuroendocrine Carcinoma of the Breast (Br-NEC) Neuroendocrine Tumor of the Breast (Br-NET) Other NENs and NEN-Like Neoplasms of the Breast Metastatic NENs Carcinomas of the Breast with Expression of General Neuroendocrine Markers Br-NENs: Just Concepts or Real Entities? References 14: Genitourinary Neuroendocrine Neoplasms Background Renal NENs Renal NET Renal NEC and MiNEN NENs of the Urinary Bladder NET of the Urinary Bladder NEC and MiNEN of the Urinary Bladder Prostatic NENs Prostatic Adenocarcinoma with Neuroendocrine Differentiation Immunoreactivity for General Neuroendocrine Markers in Otherwise Morphologically Typical Prostatic Adenocarcinoma Adenocarcinoma with Well-Differentiated Neuroendocrine Cells Prostatic Carcinoma with Amphicrine Features Prostatic NETs Prostatic NECs Testicular NENs Testicular NET Neuroendocrine Neoplasms of the Uterus NENs of the Uterine Cervix NETs of the Uterine Cervix NECs of the Uterine Cervix NENs of the Endometrium NETs of the Endometrium NECs of the Endometrium Neuroendocrine Neoplasms of the Ovary Ovarian NETs Ovarian NECs References 15: Skin Neuroendocrine Neoplasms Introduction Skin NEN Included in the 2019 Who Classification of Skin Tumors Merkel Cell Carcinoma Molecular Prognostic and Therapeutic Targets P53 and RB1 Pathway Genes KIT Receptor Tyrosine Kinase TERT Promoter PI3K/AKT MAP Kinase β-catenin Tissue Inhibitors of Metalloproteinases (TIMPs) PD1/PDL-1 BRAF Pathology Report Surgery and Systemic Therapy Conclusions Endocrine Mucin-Producing Sweat Gland Carcinoma Skin NEN Not Recorded in New Who Classification of Skin Tumors Neuroendocrine Tumor (NET) of the Skin Carcinoma with Neuroendocrine Differentiation Take Home Message References 16: Metastatic Neuroendocrine Neoplasms of Unknown Primary Site Morphological Clues to the Primary Site Immunohistochemical Markers Useful in the Detection of the Occult Primary Site Transcription Factors in NENs Caudal Type Homeobox 2 (CDX2) Thyroid Transcription Factor 1 (TTF1) Orthopedia Homeobox (OTP) Paired Box Genes (PAX5, PAX6, and PAX8) Insulin Gene Enhancer Binding Protein Isl-1 (Islet 1) Pancreatic and Duodenal Homeobox 1 (PDX1) Human Homeobox Proteins NK (Nkx) GATA Transcription Factors Estrogen and Progesterone Receptors (ER and PR) Pituitary Transcription Factors T Box Transcription Factor (TPIT) Pituitary-Specific Transcription Factor 1 (PIT1) Steroidogenic Factor 1 (SF1) Hormonal Markers Other Markers Cytokeratins Carcinoembryonic Antigen (CEA) Prostate-Specific Acid Phosphatase (PSAP; Also Known as Prostatic Acid Phosphatase, PAP or PRAP) Tyrosine Hydroxylase (TH) Somatostatin Receptors (SSTRs) Metastatic NENs in Specific Sites: Differential Diagnosis with Primary Neuroendocrine Neoplasms Specific Diagnostic Issues in the Lung, Thymus, and Thyroid Specific Diagnostic Issues in the Mammary Gland Specific Diagnostic Issues in the Gonads Specific Diagnostic Issues in the Sellar Region Conclusion References 17: Cytology of Neuroendocrine Neoplasms General Cytomorphology General Immunohistochemical and Immunocytochemical Profile Pancreas and Biliary Tract Morphology Ancillary Techniques Standardized Reporting Differential Diagnosis Skin Upper Respiratory Tract and Lung Pituitary Thyroid Morphology Ancillary Techniques Differential Diagnosis Standardized Reporting Parathyroid Extra-Adrenal Paraganglia and Adrenal Medulla Breast Genitourinary Tubular Gut Retinoblastoma References 18: Inherited Neuroendocrine Neoplasms Introduction Pituitary Neuroendocrine Neoplasms Thyroid Neuroendocrine Neoplasms Parathyroid Neuroendocrine Neoplasms Lung and Thymic Neuroendocrine Neoplasms Gastric Neuroendocrine Neoplasms Intestinal Neuroendocrine Neoplasms Pancreatic Neuroendocrine Neoplasms Paraganglial Neuroendocrine Neoplasms (Pheochromocytoma and Paraganglioma, PPGL) Role of Medical Geneticist in the Workup of Inherited Neuroendocrine Neoplasia Syndromes Neuroendocrine Neoplasia Inheritance and Genetic Testing Approach Nomenclature on Genetic Testing Results References 19: The Management of Neuro-Endocrine Neoplasms Introduction Surgery Surgically Resectable Disease Surgical Treatment for Advanced Disease Medical Therapy Targeted Radiation Therapy Symptom-Directed Therapies Additional Treatment Options Future Directions References Index
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