The Scid Mouse: Characterization and Potential Uses

Front Matter....Pages I-XII
Front Matter....Pages 1-1
The scid Mutation: Occurrence and Effect....Pages 3-9
Pleiotropic Effects of the scid Mutation: Effects on Lymphoid Differentiation and on Repair of Radiation Damage....Pages 11-17
Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7....Pages 19-25
Phenotype and Differentiation Stage of Scid Mouse Thymocytes....Pages 27-32
Growth Requirements of B Lineage Lymphocytes From Scid and Normal Mice....Pages 33-37
Defect of Scid Mouse Revealed in In Vitro Culture Systems....Pages 39-46
Natural Killer Cells and Their Precursors in Mice With Severe Combined Immunodeficiency....Pages 47-52
Front Matter....Pages 53-53
Nature of the scid Defect: A Defective VDJ Recombinase System....Pages 55-62
Rearrangement of T Cell Receptor Delta Genes in Thymus of Scid Mice....Pages 63-67
Abnormal V(D)J Recombination in Murine Severe Combined Immune Deficiency: Absence of Coding Joints and Formation of Alternative Products....Pages 69-75
The scid Mutation Disrupts Gene Rearrangement at the Rejoining of Coding Strands....Pages 77-84
The Effect of the scid Mutation on Mechanism and Control of Immunoglobulin Heavy and Light Chain Gene Rearrangement....Pages 85-94
Front Matter....Pages 95-95
The Utilization of the scid Mutation in the Study of T Cell Development....Pages 97-105
Transgenic Scid Mice With a Functionally Rearranged Immunoglobulin Heavy Chain Gene....Pages 107-114
Front Matter....Pages 115-115
T Cell Leakiness in Scid Mice....Pages 117-123
Limited Clonal Diversity of Serum Immunoglobulin in Leaky Scid Mice....Pages 125-136
Pauciclonal B Cell Involvement in Production of Immunoglobulin in Scid Ig + Mice....Pages 137-147
Front Matter....Pages 149-149
Reconstitution of Scid Mice by Injection of Varying Numbers of Normal Fetal Liver Cells into Scid Neonates....Pages 151-159
Reconstitution of Lymphocyte Subsets in Scid Mice by Transplantation of Fetal Primordia....Pages 161-168
Use of the Scid Mouse Transplantation System in Studies of Lymphocyte Differentiation....Pages 169-172
Front Matter....Pages 149-149
The Scid Mouse as a Model to Identify and Quantify Myeloid and Lymphoid Stem Cells....Pages 173-180
Front Matter....Pages 181-181
The Scid-hu Mouse: Current Status and Potential Applications....Pages 183-193
Studies of HIV Infection and the Development of Epstein-Barr Virus-Related B Cell Lymphomas Following Transfer of Human Lymphocytes to Mice With Severe Combined Immunodeficiency....Pages 195-199
Human Lung Tumors, Patients’ Peripheral Blood Lymphocytes and Tumor Infiltrating Lymphocytes Propagated in Scid Mice....Pages 201-210
Adoptive Transfer of Human Peripheral Blood Lymphocytes (PBL) in Scid Mice....Pages 211-217
Establishment of Assays for Human Hematopoietic Cells in Immune Deficient Mice....Pages 219-224
Front Matter....Pages 225-225
Scid Mice in Reproductive Biology....Pages 227-234
T Cell-Independent Macrophage Activation in Scid Mice....Pages 235-242
 Pneumocystis carinii Pneumonia in scid/scid Mice....Pages 243-249
Immunobiology of Bone Marrow Transplantation: Studies Using Scid Mice....Pages 251-258
Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice....Pages 259-263