The Sanford Guide to Antimicrobial Therapy 2022

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	THE SANFORD GUIDE
	THE SANFORD GUIDE To Antimicrobial Therapy 2022
	ABBREVIATIONS
	ABBREVIATIONS (2)
	ABBREVIATIONS OF JOURNAL TITLES
	Treatment based on presumed site or type of infection. In selected instances, treatment and prophylaxis based on identification of pathogens. Regimens should be reevaluated based on pathogen isolated, antimicrobial susceptibility determination, and individual host characteristics. (Abbreviations on 2)
	3 Drugs & peds dosage (all po unless specified) for acute otitis media: Amoxicillin UD (usual dose) = 40 mg/kg per day div ql2h or q8h. Amoxicillin HD (high dose) = 90 mg/kg per day div q12h or q8h.
	LYMPH NODES (approaches below apply to lymphadenitis without an obvious primary source)
	Lymphadenitis, acute
	” Treatment of Group A, C & G strep: Treatment durations are from approved package inserts. Subsequent studies indicate efficacy of shorter treatment courses. All po unless otherwise indicated.
	TABLE 3 - SUGGESTED DURATION OF ANTIBIOTIC THERAPY FOR SELECTED CLINICAL SYNDROMES IN IMMUNOCOMPETENT PATIENTS
	Overview of variables affecting duration of therapy
	TABLE SB - ANTIBACTERIAL TREATMENT: PRESUMED OR CONFIRMED ENTEROBACTERALES PRODUCING EXTENDED-SPECTRUM BETA-LACTAMASES (ESBL)
	TABLE 50 - TREATMENT OPTIONS FOR DIFFICULT TO TREAT PSEUDOMONAS AERUGINOSA
	TABLE 6 - SUGGESTED MANAGEMENT OF SUSPECTED OR CULTURE-POSITIVE METHICILLIN-RESISTANT S. AUREUS INFECTIONS
	104
	108
	TABLE 9C - ENZYME -AND TRANSPORTER- MEDIATED INTERACTIONS OF ANTIMICROBIALS
	TERMINOLOGY:
	REFERENCES:
	120
	122
	124
	125
	128
	CLASS, AGENT, GENERIC NAME 	(TRADE NAME)	 POLYMYXINS (POLYPEPTIDES) (continued)
	Other adult dosing:
	Pediatric dosing:
	TABLE 10В - ANTIMICROBIAL AGENTS ASSOCIATED WITH PHOTOSENSITIVITY
	134
	TABLE ЮС - AMINOGLYCOSIDE ONCE DAILY AND MULTIPLE DAILY DOSING REGIMENS (If estimated CrCI <90 mL/min or if on dialysis, see Table 17A, page 248)
	•	General Note: dosages are given as once daily dose (OD) and multiple daily doses (MDD).
	•	For calculation of dosing weight in non-obese patients use Ideal Body Weight (IBW):
	TABLE 10E - INHALATION ANTIBIOTICS
	TABLE 10F - ECMO DRUG DOSING ADJUSTMENT
	139
	I
	TABLE 10G - QTc PROLONGATION
	Management
	148
	1	Published data from patients intolerant of or refractory to conventional Ampho В deoxycholate. None of the lipid Ampho В preps has shown superior efficacy compared to Ampho В in prospective trials (except liposomal Ampho В was more effective vs Ampho В in rx of disseminated histoplasmosis at 2 wks). Dosage equivalency has not been established (CID 36:1500, 2003).
	154
	TABLE 12A - TREATMENT OF MYCOBACTERIAL INFECTIONS'-
	2	3
	TABLE 12A (7)
	FIGURE 2: TREATMENT ALGORITHM FOR CULTURE-POSITIVE PULMONARY TUBERCULOSIS [Modified from MMWR 52(RR-11):1, 2003]
	163
	168
	169
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	'NFECT.NG ORGANISM	[		 р.^у ■ SUGGESTED REGIMENS	COMMENTS
	PROTOZOA—EXTRAINTESTINAL
	180
	182
	188
	ADVERSE REACTIONS/COMMENTS
	189
	194
	198
	200
	202
	204
	206
	Overview
	209
	Legend, Warnings and Notes Regarding Regimens
	214
	Elimination
	,H rx to be discontinued, stop Efavirenz 1-2 wks I before stopping companion drugs. • •
	218
	223
	TABLE 14E - HEPATITIS A & HBV TREATMENT
	Hepatitis В Virus (HBV): Treatment
	TABLE 14F - HCV TREATMENT REGIMENS AND RESPONSE
	3.	HCV Treatment Regimens
	Comments
	228
	Pregnant women—intrapartum antimicrobial prophylaxis procedures:
	230
	TABLE 15В - ANTIBIOTIC PROPHYLAXIS TO PREVENT SURGICAL INFECTIONS IN ADULTS*
	232
	TABLE 15C - ANTIMICROBIAL PROPHYLAXIS FOR THE PREVENTION OF BACTERIAL ENDOCARDITIS IN PATIENTS WITH UNDERLYING CARDIAC CONDITIONS*
	A. HIV OCCUPATIONAL EXPOSURE
	FOLLOW-UP
	B. HIV NON-OCCUPATIONAL EXPOSURE
	TABLE 15E - PREVENTION OF SELECTED OPPORTUNISTIC INFECTIONS IN HUMAN HEMATOPOIETIC CELL TRANSPLANTATION (HCT) OR SOLID ORGAN TRANSPLANTATION (SOT) IN ADULTS WITH NORMAL RENAL FUNCTION
	References:
	TABLE 16 - PEDIATRIC DOSING (AGE >28 DAYS)
	Editorial Note
	TABLE 17A - DOSAGE OF ANTIMICROBIAL DRUGS IN ADULT PATIENTS WITH RENAL IMPAIRMENT
	254
	256
	258
	262
	TABLE 17C - ANTIMICROBIAL DOSING IN OBESITY
	Drug
	TABLE 18 - ANTIMICROBIALS AND HEPATIC DISEASE: DOSAGE ADJUSTMENT--
	TABLE 19 - TREATMENT OF CAPD PERITONITIS IN ADULTS
	Principles: Empiric antibiotic therapy
	Intraperitoneal (IP) therapy
	Indications for removal of CAPD catheter
	TABLE 20В - RABIES POSTEXPOSURE PROPHYLAXIS All wounds should be cleaned immediately & thoroughly with soap & water. This has been shown to protect 90% of experimental animals!’
	Postexposure Rabies Immunization Schedule
	PHONE/FAX WEBSITE(S)
	ANTIPARASITIC DRUGS & PARASITOLOGY INFORMATION
	BIOTERRORISM
	HEPATITIS В
	HEPATITIS C
	CDC
	HIV
	IMMUNIZATIONS
	OCCUPATIONAL EXPOSURE, BLOOD-BORNE PATHOGENS (HiV, HEPATITIS В & C)
	N>
	3
	ыг
	LLZ
	6ZZ
	-effect) -..	- Suggestedmanagement-
	282
	288
	290
	308
	TABLE 23 - LIST OF GENERIC AND TRADE NAMES
	GENERIC NAME: TRADE NAMES
	78
	TABLE 4A - ANTIBACTERIAL ACTIVITY SPECTRA
	RAPID REFERENCE