The Role of Sphingolipids in Cancer Development and Therapy

Content: 
Copyright
Page iv

Contributors
Pages ix-xi

Preface
Pages xiii-xvii
James S. Norris

Chapter One - Interdiction of Sphingolipid Metabolism to Improve Standard Cancer Therapies
Pages 1-36
Thomas H. Beckham, Joseph C. Cheng, S. Tucker Marrison, James S. Norris, Xiang Liu

Chapter Two - Diverse Functions of Ceramide in Cancer Cell Death and Proliferation
Pages 37-58
Sahar A. Saddoughi, Besim Ogretmen

Chapter Three - Ceramide Glycosylation Catalyzed by Glucosylceramide Synthase and Cancer Drug Resistance
Pages 59-89
Yong-Yu Liu, Ronald A. Hill, Yu-Teh Li

Chapter Four - Use of Acid Sphingomyelinase for Cancer Therapy
Pages 91-115
Radoslav Savić, Edward H. Schuchman

Chapter Five - Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate
Pages 117-141
Olivier Cuvillier, Isabelle Ader, Pierre Bouquerel, Leyre Brizuela, Cécile Gstalder, Bernard Malavaud

Chapter Six - Therapeutic Potential of Targeting SK1 in Human Cancers
Pages 143-200
Heba Alshaker, Lysann Sauer, Danielle Monteil, Silvia Ottaviani, Shyam Srivats, Torsten Böhler, Dmitri Pchejetski

Chapter Seven - Sphingosine Kinase 1 in Cancer
Pages 201-235
Linda A. Heffernan-Stroud, Lina M. Obeid

Chapter Eight - Natural Products as Platforms for the Design of Sphingolipid-Related Anticancer Agents
Pages 237-281
Antonio Delgado, Gemma Fabri`s, Josefina Casas, José Luis Abad

Index
Pages 283-288