The Role of Immune Mechanisms in Cardiovascular Disease

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Mechanisms and Genetics of Autoimmunity....Pages 3-16
Molecular Pathogenesis of Myocarditis and Cardiomyopathy: Analysis of Virus-Receptor Interactions and Tyrosine Phosphorylation Events....Pages 17-26
Coxsackievirus Genetics and the Cardiovirulent Viral Phenotype....Pages 27-34
Lessons from Animal Models of Viral Myocarditis....Pages 35-43
The Role of Cytokines in the Pathogenesis of Myocarditis....Pages 44-56
The Role of Heart Infiltrating Cells in Myocyte Injury....Pages 57-64
The Significance of T Cell Responses in Human Myocarditis....Pages 65-76
The Possible Pathogenic Role of Autoantibodies in Myocarditis and Dilated Cardiomyopathy....Pages 77-84
The Adenine Nucleotide Translocator: A Major Autoantigen in Myocarditis and Dilated Cardiomyopathy....Pages 85-100
Immunohistochemical Analysis of Inflammatory Heart Disease....Pages 101-121
Front Matter....Pages 123-123
Adhesion Molecule Induction and Expression in Neutrophil-Induced Myocardial Injury....Pages 125-137
Molecular Mechanisms of Adhesion of Staphylococcus aureus to Cardiac Surfaces and Vegetations....Pages 138-144
Endotoxins as Potential Mediators of Myocardial Depression....Pages 145-156
Front Matter....Pages 157-157
Transplant Associated Coronary Artery Disease....Pages 159-173
Role of Ischemia/Reperfusion Injury in Organ Transplantation....Pages 174-185
The Role of NO Synthases in Immunological Diseases: Importance for Left Ventricular Function....Pages 186-193
The Role of the Endothelium in Atherosclerosis....Pages 194-204
Immune and Inflammatory Responses in the Human Atherosclerotic Plaque....Pages 205-212
Inflammation in Acute Coronary Syndromes....Pages 213-229
Immunological Mechanisms in Myocardial Reperfusion Injury....Pages 230-237
Front Matter....Pages 157-157
Metalloproteinases and Atherosclerotic Plaque Rupture....Pages 238-246
Potential Role of Human Cytomegalovirus and Its Interaction with p53 in Coronary Restenosis....Pages 247-258
Front Matter....Pages 259-259
Protective Effects of Monoclonal Antibodies to Cell Adhesion Glycoproteins in Models of Cardiac Reperfusion Injury and Leukocyte/Vascular Responses....Pages 261-269
Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty Restenosis?....Pages 270-281
Treatment of Inflammatory Cardiomyopathy with Corticosteroids....Pages 282-290
The Genetics of Dilated Cardiomyopathy....Pages 291-296
Mechanisms of Allograft Rejection and Therapeutic Options....Pages 297-311
Back Matter....Pages 313-319