The Placenta: From Development to Disease

The Placenta
From Development to Disease......Page 2
Dedication......Page 3
Title......Page 4
Copyright......Page 5
Contents......Page 6
List of Contributors......Page 8
Preface......Page 14
PART I - Fetal Origins of Adult Disease/Programming......Page 15
CHAPTER 1- Maternal Undernutrition and FetalProgramming: Role of the Placenta......Page 17
CHAPTER 2 Cardiovascular Health and MaternalPlacental Syndromes......Page 24
PART II - Placental Development,Physiology, and Immunology......Page 31
CHAPTER 3 Development and Anatomy ofthe Human Placenta......Page 33
CHAPTER 4 Immunologic Aspects of Pregnancy......Page 41
CHAPTER 5 Vascular Development inthe Placenta......Page 50
CHAPTER 6 Hypoxia and the Placenta......Page 57
CHAPTER 7 Placental Metabolism......Page 64
CHAPTER 8 Placental Hormones: Physiology,Disease, and Prenatal Diagnosis......Page 71
CHAPTER 9 Placental Transfer in Healthand Disease......Page 80
CHAPTER 10 Placental Fat Trafficking......Page 89
CHAPTER 11 Maternal–Fetal Cell Traffickingand Microchimerism......Page 95
CHAPTER 12 Imprinting in the Human Placenta......Page 101
CHAPTER 13 Placental Membranes and AmnioticFluid Retention......Page 110
PART III Examination of the Placenta, Membranes,and Cord......Page 117
CHAPTER 14 Examination of the Placenta,Membranes, and Cord:Basic Examination......Page 119
CHAPTER 15 The Umbilical Cord......Page 128
CHAPTER 16 Ultrasound Imaging and DopplerStudies of the Placenta......Page 136
CHAPTER 17 Magnetic Resonance Imaging (MRI)and Positron Emission Tomography(PET) of the Placenta......Page 145
CHAPTER 18 Chorionic Villus Sampling andAmniocentesis......Page 152
CHAPTER 19 Cordocentesis and Fetoscopy......Page 159
PART IV Research Techniques toStudy the Placenta......Page 167
CHAPTER 20 Trophoblast Isolation and Culture......Page 169
CHAPTER 21 Isolation and Culture of HumanUmbilical Vein Endothelial Cells......Page 177
CHAPTER 22 Perfusion Technique for Studyingthe Placenta Cotyledon......Page 184
CHAPTER 23 Three-Dimensional CultureModeling of the Placenta......Page 191
CHAPTER 24 The Use of Ultrasound ContrastAgents in Placental Imaging......Page 196
CHAPTER 25 Microscopy and the Placenta......Page 203
CHAPTER 26 Proteomics and the Placenta......Page 211
CHAPTER 27 Stable Isotope Methodologiesfor the Study of Transport andMetabolism In Vivo......Page 221
PART V Medical Diseases and Complications......Page 227
CHAPTER 28 The Role of the Placenta inAutoimmune Disease andEarly Pregnancy Loss......Page 229
CHAPTER 29 The Placenta in Preterm PrelaborRupture of Membranes andPreterm Labor......Page 236
CHAPTER 30 Diabetes and the Placenta......Page 242
CHAPTER 31 Placental Origins of IntrauterineGrowth Restriction......Page 251
CHAPTER 32 The Placenta in Preeclampsia......Page 260
CHAPTER 33 Thrombophilia and the Placenta......Page 267
CHAPTER 34 Infections in the Placenta......Page 275
CHAPTER 35 Aneuploidy and Polyploidy......Page 284
CHAPTER 36 Gestational Trophoblastic Diseaseand Placental Tumors......Page 292
CHAPTER 37 Multiple Gestation and Twin–TwinTransfusion Syndrome......Page 301
CHAPTER 38 Previa and Abruption......Page 310
CHAPTER 39 The Placenta as a Functional Barrierto Fetal Drug Exposure......Page 317
CHAPTER 40 Placental Drug Transport......Page 324
PART VI Future Clinical Applications......Page 333
CHAPTER 41 Umbilical Cord Blood Banking......Page 335
CHAPTER 42 Stem Cells from the Placenta......Page 341
CHAPTER 43 Fetal DNA, RNA, and PrenatalDiagnosis......Page 348
index......Page 353