The Pineal Gland and Cancer: Neuroimmunoendocrine Mechanisms in Malignancy

Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
Some Historical Remarks Concerning Research on the Pineal Gland and Cancer....Pages 3-4
Biology of the Pineal Gland and Melatonin in Humans....Pages 5-49
The Role of Melatonin in the Neuroendocrine System: Multiplicity of Sites and Mechanisms of Action....Pages 50-65
The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation....Pages 66-116
Melatonin Involvement in Cancer: Methodological Considerations....Pages 117-149
Front Matter....Pages 151-151
Analysis of Melatonin in Patients with Cancer of the Reproductive System....Pages 153-176
Melatonin in Patients with Cancer of Extra-Reproductive Location....Pages 177-196
The Modulation of Melatonin in Tumor-Bearing Animals: Underlying Mechanisms and Possible Significance for Prognosis....Pages 197-209
The Pineal Gland, Melatonin, and Neoplastic Growth: Morphological Approach....Pages 210-217
Front Matter....Pages 219-219
In Vitro Effects of Melatonin on Tumor Cells....Pages 221-239
Melatonin and Colon Carcinogenesis....Pages 240-258
Role of Extrapineal Melatonin and Related APUD Series Peptides in Malignancy....Pages 259-274
A Survey of the Evidence That Melatonin and Unidentified Pineal Substances Affect Neoplastic Growth....Pages 275-293
Experimental Studies of the Pineal Gland Preparation Epithalamin....Pages 294-306
Front Matter....Pages 307-307
An Overview of the Neuroendocrine Regulation of Experimental Tumor Growth by Melatonin and Its Analogues and the Therapeutic Use of Melatonin in Oncology....Pages 309-342
Modulation of the Estrogen Response Pathway in Human Breast Cancer Cells by Melatonin....Pages 343-358
Benign and Tumor Prostate Cells as Melatonin Target Sites....Pages 359-364
Neuroimmunomodulation Via the Autonomic Nervous System....Pages 365-370
Melatonin and Immune Functions....Pages 371-383
Melatonin and the Immune System Therapeutic Potential in Cancer, Viral Diseases, and Immunodeficiency States....Pages 384-394
Front Matter....Pages 307-307
Melatonin Rhythms in Mice: Role in Autoimmune and Lymphoproliferative Diseases....Pages 395-407
Mechanisms Involved in the Immunomodulatory Effects of Melatonin on the Human Immune System....Pages 408-416
The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue....Pages 417-441
Reactive Oxygen Species, DNA Damage, and Carcinogenesis: Intervention with Melatonin....Pages 442-455
Could the Antiproliferative Effect of Melatonin Be Exerted Via the Interaction of Melatonin with Calmodulin and Protein Kinase C?....Pages 456-462
Front Matter....Pages 463-463
Efficacy of Melatonin in the Immunotherapy of Cancer Using lnterleukin-2....Pages 465-475
Melatonin Cancer Therapy....Pages 476-508
Front Matter....Pages 509-509
Circadian Disruption and Breast Cancer....Pages 511-517
Breast Cancer and Use of Electric Power: Experimental Studies on the Melatonin Hypothesis....Pages 518-533
Magnetic Field Exposure and Pineal Melatonin Production (Mini-Review)....Pages 534-540
Nocturnal Hormone Profiles in Healthy Humans Under the Influence of Pulsed High-Frequency Electromagnetic Fields....Pages 541-550
Weak High-Frequency (Radiofrequency, Microwave) Electromagnetic Fields: Epidemiological Evidence of Their Impact on Cancer Development and Reproductive Outcome....Pages 551-565
Back Matter....Pages 567-578