The Physical Basis of Biochemistry: The Foundations of Molecular Biophysics

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Introduction to the Principles and Practice of Biophysical Chemistry....Pages 3-7
Physical Thoughts, Biological Systems: The Application of Modeling Principles to Understanding Biological Systems....Pages 8-26
Probability and Statistics....Pages 27-40
Front Matter....Pages 41-41
Physical Principles: Energy—The Prime Observable....Pages 43-47
Physical Principles: Mechanics and Motion....Pages 48-67
Physical Principles: Waves....Pages 68-96
Physical Principles: Electrostatics....Pages 97-108
Physical Principles: Electromagnetics....Pages 109-124
Physical Principles: Quantum Mechanics....Pages 125-157
Chemical Principles....Pages 158-172
Front Matter....Pages 173-173
Measuring the Energy of a System: Energetics and the First Law of Thermodynamics....Pages 175-186
The Whole Is Greater than the Sum of Its Parts: Entropy and the Second Law....Pages 187-207
Which Way Is That System Going? The Gibbs Free Energy....Pages 208-227
Friends and Neighbors—Interactions in a System: Phase Equilibria....Pages 228-248
Spectroscopy: Analysis of Structure....Pages 249-267
Analysis of Structure: Microscopy....Pages 268-281
Scenic Overlook Backward and Forward....Pages 282-283
Front Matter....Pages 285-285
Water: A Unique Structure, a Unique Solvent....Pages 287-299
Ion-Solvent Interactions....Pages 300-318
Ion-Ion Interactions....Pages 319-329
Front Matter....Pages 285-285
Lipids in Aqueous Solution: The Formation of the Cell Membrane....Pages 330-345
Constructing a Biological State Space....Pages 346-360
Macromolecules in Solution....Pages 361-393
Molecular Modeling: Mapping Biochemical State Space....Pages 394-414
The Electrified Interface....Pages 415-426
Forces across Membranes....Pages 427-438
Front Matter....Pages 439-439
Transport: A Nonequilibrium Process....Pages 441-444
Flow in a Chemical Potential Field: Diffusion....Pages 445-454
Flow in an Electric Field: Conduction....Pages 455-469
Electrokinetic Phenomena....Pages 470-479
Kinetics: Chemical Kinetics....Pages 480-497
Kinetics: Enzymes and Electrons....Pages 498-515
Epilogue....Pages 516-516
Back Matter....Pages 517-567