The Organization of Cell Metabolism

Front Matter....Pages i-xiii
The Organization of Cell Metabolism: A Historical Vignette....Pages 1-5
Front Matter....Pages 7-7
Structural Organization of the Cytomatrix....Pages 9-25
The Cytoskeleton....Pages 27-35
Interactions within the Cytoskeleton....Pages 37-40
On the Physical Properties and Potential Roles of Intracellular Water....Pages 41-55
Diffusion of a Small Molecule in the Aqueous Compartment of Mammalian Cells....Pages 57-74
Restricted Motion of Cellular K + in Permeabilized Cells....Pages 75-77
The Intracellular Distribution of Adenosine Triphosphate....Pages 79-85
Front Matter....Pages 87-87
New Views of Cell and Tissue Cytoarchitecture: Embedment-Free Electron Microscopy and Biochemical Analysis....Pages 89-99
Understanding the Organization of Cell Metabolism in Early Embryonic Systems: Developmental Implications....Pages 101-106
Front Matter....Pages 107-107
Organization of Enzymes in the Tryptophan Pathway....Pages 109-119
Implications of Metabolic Compartmentation in Prokaryotic Cells....Pages 121-129
Organization of Glucose Metabolism: A Model of Compartments by Poly-Isozymic Complexes....Pages 131-142
Direct Transfer of Metabolites Via Enzyme-Enzyme Complexes: Evidence and Physiological Significance....Pages 143-163
Energetic Consequence of Dynamic Enzyme-Enzyme Interaction....Pages 165-168
Mitochondrial Hexokinase: Interactions between Glycolysis and Oxidative Phosphorylation....Pages 169-170
Diffusion and Perfusion in the Living Cell: Implications for Metabolic Regulation and Organization....Pages 171-173
Front Matter....Pages 175-175
Interactions of Mitochondrial Matrix Enzymes with Mitochondrial Inner Membranes....Pages 177-189
Some Aspects of Enzyme Organization in the Citric Acid Cycle....Pages 191-197
Enzyme Interactions in the Citric Acid Cycle and the Aspartate-Malate Shuttle....Pages 199-208
Front Matter....Pages 175-175
EPR Measurements of Conformational Changes on the E1 Component of the Pyruvate Dehydrogenase Complex From Escherichia Coli ....Pages 209-212
Front Matter....Pages 213-213
Organization and Control of Energy Metabolism in Anaerobic Microorganisms....Pages 215-231
Electron and Proton Flow in Hepatocytes During Fatty Acid and Pyruvate Oxidation: Implications for Energy Transduction and Heat Production....Pages 233-250
Experimental Analysis of Spatiotemporal Organization of Metabolism in Intact Cells: The Enigma of “Metabolic Channeling” and “Metabolic Compartmentation”....Pages 251-275
Functional and Structural Heterogeneity of the Inner Mitochondrial Membrane....Pages 277-287
Front Matter....Pages 289-289
Complex Patterns of Excitability and Oscillations in a Biochemical System....Pages 291-305
Reaction-Diffusion Coupling in Immobilized Enzyme Systems: Ionic interactions....Pages 307-325
On Parts and Wholes in Metabolism....Pages 327-337
Maxwell’s Demons in Channelled Metabolism: Paradoxes and their Resolution....Pages 339-356
Molecular Machines and Energy Channelling....Pages 357-365
Cytosociological Aspects of Enzyme Action....Pages 367-380
Back Matter....Pages 381-389