The neurobiology of disease: contributions from neuroscience to clinical ...

Dedication......Page 8
Contents......Page 10
Contributors......Page 13
Preface......Page 18
Part I: Physiology and pathophysiology of nerve fibres......Page 22
Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve......Page 24
Molecular anatomy of the node of Ranvier: newer concepts......Page 34
Delayed rectifier type potassium currents in rabbit and rat axons and rabbit Schwann cells......Page 50
Axonal signals for potassium channel expression in Schwann cells......Page 58
Ion channels in human axons......Page 68
An in vitro model of diabetic neuropathy: electrophysiological\rstudies......Page 82
Autoimmunity at the neuromuscular junction......Page 90
Immunopathology and pathophysiology of experimental autoimmune encephalomyelitis......Page 96
Pathophysiology of human demyelinating neuropathies......Page 107
Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease......Page 116
Mechanisms of relapse and remission in multiple sclerosis......Page 139
Glial transplantation in the treatment of myelin loss or deficiency......Page 145
Part II: Pain......Page 170
Human nociceptors in health and disease......Page 172
Sensory consequences of inflammation......Page 183
Non-voluntary muscle activity and myofascial pain syndromes......Page 190
Is there a mechanism for the spinal cord to remember pain?......Page 198
The neurophysiological basis of pain relief by acupuncture......Page 210
Part III: Control of central nervous system output......Page 220
Synaptic transduction in neocortical neurones......Page 222
Cortical circuits, synchronization and seizures......Page 231
Physiologically induced changes of brain temperature and their effect on extracellular field potentials......Page 242
Fusimotor control of the respiratory muscles......Page 252
Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles......Page 262
The cerebellum and proprioceptive control of movement......Page 268
Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control......Page 278
Central actions of curare and gallamine: implications for reticular reflex myoclonus?......Page 287
Pathophysiology of upper motoneurone disorders......Page 297
Modulation of hypoglossal motoneurones by thyrotropin-releasing hormone and serotonin......Page 304
Serotonin and central respiratory disorders in the newborn......Page 313
Are medullary respiratory neurones multipurpose neurones?......Page 320
Reflex control of expiratory motor output in dogs......Page 330
Abnormal thoraco-abdominal movements in patients with chronic lung disease......Page 339
Respiratory rhythms and apnoeas in the newborn......Page 348
Cardiorespiratory interactions during apnoea......Page 358
Impairment of respiratory control in neurological disease......Page 369
The respiratory muscles in neurological disease......Page 379
Part IV: Development, survival, regeneration and death......Page 392
Axonal growth and plasticity in the adult nervous system......Page 394
Target dependence of motoneurones......Page 400
Rescue of neurones cross-regenerated into foreign targets......Page 416
Development and repair of neonatal mammalian spinal cord in culture......Page 426
Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf\'s nucleus......Page 432
Excitotoxicity in motor neurone diseases......Page 448
Index......Page 457