The Molecular Biology of Autoimmune Disease

Front Matter....Pages I-XII
Organization and Expression of Human V H Genes....Pages 1-14
Immunoglobulin Kappa Variable Gene Segment Usage during Ontogeny....Pages 15-22
Molecular Analysis of T Lymphocyte Recognition....Pages 23-29
T Cell Development in T Cell Receptor Transgenic Mice....Pages 31-44
Target Sequences and Accessibility for Chromosomal Translocations Involving T-Cell Receptor Genes....Pages 45-54
Introduction....Pages 55-59
Structure of Human Major Histocompatibility Complex Class II Genes....Pages 61-69
Dissection of the Roles of Specific Class II Antigens and Accessory Molecules in Antigen Presentation....Pages 71-83
The Fine Specificity of Recognition of Influenza Virus Proteins by Human Cytotoxic T Cells....Pages 85-96
Chairman’s Summing up Evolutionary Analysis of HLA Class II Polymorphisms....Pages 97-107
Molecular Genetics of Two Major Thyroid Auto-Antigens: Thyroglobulin and Thyroperoxidase....Pages 109-120
Analysis of Autoantigenic Determinants of Thyroid Peroxidase Antigen, Generated Using Polymerase Chain Reaction....Pages 121-134
Glycolipid Antigens in Type I Diabetes Mellitus and Its Long Term Complications....Pages 135-145
On the Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis....Pages 147-158
Acetylcholine Receptor-Expressing Fibroblasts....Pages 159-170
The Interaction between MHC Class II Molecules and Immunogenic Peptides....Pages 171-179
Molecular Mimicry between Virus Proteins and Autoantigens in Autoimmunity....Pages 181-191
Introduction....Pages 193-198
The Advantages of Limiting the T Cell Repertoire for Antigen & MHC....Pages 199-208
Functional Dissociation of T Cell Sites; Immunogenic, Antigenic and Pathogenic Sites....Pages 209-219
Autoreactive Cloned T Cell Lines in Murine Insulin-Dependent Diabetes Mellitus....Pages 221-234
Chairman’s Summing up....Pages 235-241
HLA Class II Sequence Polymorphism and Autoimmunity....Pages 243-250
HLA-DQ and Diabetes Mellitus: A Genetic and Structural Paradigm for Models of Disease Susceptibility....Pages 251-262
A Single Recessive Non-MHC Diabetogenic Gene Determines the Development of Insulitis in NOD Mice....Pages 263-272
Autoimmunity — More Than the MHC?....Pages 273-284
Chairman’s Summing up....Pages 285-289
The Idiotypic Network in Experimental Autoimmune Thyroiditis (EAT): Towards a New Conception of Autoimmune Reactivity....Pages 291-300
Factors Affecting Diabetes in Rodent Models of Insulin Dependent Diabetes Mellitus....Pages 301-311
Cells and Immune Processes Contributing to Pancreatic Islet Inflammation....Pages 313-323
Synopsis of Paper Entitled “Ir Gene Expression, Antigen Processing and Autoantigen Characterization in Autoimmune Diseases of the Nervous System”....Pages 325-331
Mechanisms of Resistance to Autoimmune Disease Induced by T-Cell Vaccination....Pages 333-342
T Cell Reactivity to Acetylcholine Receptor in Myasthenia Gravis....Pages 343-350
Type I Diabetes as a “Mendelian” and “Regulated” Immune Process....Pages 351-362
The Cloning Road to the TSH Receptor and Autoimmune Graves’ Disease....Pages 363-378
Thyroid Peroxidase: Studies on Auto-Antibody Recognition, Gene Expression and Secondary Structure Prediction....Pages 379-390
Sjogren’s Syndrome, a Model to Study Autoimmunity and Malignancy....Pages 391-398
Back Matter....Pages 399-406