The lymphoid neoplasms

 Content: INTRODUCTION Introduction to the lymphoid neoplasms Historical perspective: the evolution of modern concepts of lymphoid neoplasia  EPIDEMIOLOGY Descriptive epidemiology Causes and prevention of lymphoma Immunologic and genetic predisposition Epidemiology of exogenous human retroviruses associated with hematologic malignancies Herpesviruses and lymphoma Other microorganisms associated with lymphoid neoplasms  IMMUNOBIOLOGY Overview of the immune system Ontogeny of T and natural killer cells Ontogeny of B cells Cellular immunobiology of lymph nodes and spleen Cellular immunobiology of extranodal lymphoid tissue Biology of plasma cells Interleukins and lymphoid neoplasia Lymphocyte homing and the dissemination of lymphoid malignancies Mouse models of human B lymphoid neoplasms  CLASSIFICATION AND PATHOGENESIS Classification of lymphoid neoplasms Borderlands between pathological entities: composite lymphomas Chromosomal and molecular alterations in lymphoid malignancies: basic principles and detection methods Molecular basis of chromosomal translocations Genesis and consequences of genetic lesions in lymphoma classification Gene expression patterns in lymphoma classification Immunodeficieny, inherited and acquired, and lymphomagenesis Chronic inflammation, including autoimmunity, and lymphogenesis  PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS Lymphoblastic lymphomas and leukemias Chronic lymphoid leukemias and u heavy chain disease Hairy cell leukemia Mantle cell lymphoma Marginal zone lymphomas Follicular lymphoma Burkitt lymphoma Diffuse large B cell lymphomas Hodgkin lymphoma Plasma cell neoplasms Natural killer (NK) cell neoplasms Anaplastic large cell lymphoma Mycosis fungoides and Sezary Syndrome: pathophysiology and pathology Other peripheral T cell lymphomas: pathology and molecular pathogenesis  PRESENTING FEATURES, DIAGNOSIS AND STAGING Presenting features of lymphoid neoplasms The art of histological diagnosis Immunophenotyping as a diagnostic and prognostic tool The utility of molecular genetic studies in the diagnosis, prognostic assessment and monitoring of lymphoid malignancies Radiologic, ultrasound and magnetic resonance imaging Radionuclide imaging Staging systems and staging investigations at presentation Special aspects of diagnosis in developing countries Imaging lymphomas in developing countries  GENERAL PRINCIPLES OF MANAGEMENT Emergency management in lymphoid malignancies Systemic therapy of lymphoma Role of radiation therapy Response assessment and follow-up of the patient with malignant lymphoma Prognostic factors and risk adaptation Second-line therapy for lymphoid neoplasms High-dose therapy with stem cell rescue Management of lymphoid neoplasia during pregnancy Management of lymphoid malignancies in the infant Management of lymphoid neoplasms in the elderly Management of lymphomas at extranodal locations Special aspects of management of lymphomas in developing countries Late effects of cancer treatment and quality of life  MANAGEMENT OF SPECIFIC DISEASES Lymphoblastic lymphoma and leukemia in children Acute lymphoblastic leukemia and lymphoma in adults Small B cell lymphomas and leukemias with hairy cell leukemia Mantle cell lymphoma Marginal zone lymphomas Follicular lymphoma Burkitt lymphoma/leukemia in children Burkitt and Burkitt like lymphoma/leukemia in adults Diffuse large B cell lymphoma in children Diffuse large B cell lymphomas in adults Hodgkin lymphoma in adults Hodgkin lymphoma in children Plasma cell neoplasms The management of natural killer cell malignancies Anaplastic large cell lymphoma in adults Anaplastic large cell lymphoma in children Mycosis fungoides and Sezary Syndrome Adult T-cell leukemia/lymphoma Other peripheral T cell lymphomas HIV-associated lymphoid neoplasms Lymphoid neoplasms in immunodeficiency, immunosuppression, and autoimmunity Uncommon histologic subtypes of non-Hodgkin lymphoma in children  FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT Molecular profiling and lymphoma diagnosis New therapies for lymphoid neoplasms Monoclonal antibody therapy for lymphomas and leukemias Cellular therapies for lymphoma Vaccine therapies Lymphoma microenvironment Molecular pathway therapy for non-Hodgkin lymphomas Therapeutic strategies employing viral-associated targets