The Kidney and Hypertension in Diabetes Mellitus

Front Matter....Pages i-xxviii
Historical Aspects of Diabetes and Diabetic Renal Disease....Pages 1-5
The Nature of the Diabetic Glomerulus: Pressure-Induced and Metabolic Aberrations....Pages 7-16
Definition of Diabetic Renal Disease in Insulin-Dependent Diabetes Mellitus Based on Renal Function Tests....Pages 17-29
Retinopathy in Relation to Albuminuria and Blood Pressure in IDDM....Pages 31-38
Microalbuminuria and Cardiovascular Disease....Pages 39-50
The Heart in Diabetes: Results of Trials....Pages 51-60
Albuminuria in Non-Insulin-Dependent Diabetes — Renal or Extrarenal Disease?....Pages 61-72
The Clinical Course of Renal Disease in Caucasian NIDDM Patients....Pages 73-83
Use of the Albumin/Creatinine Ratio in Patient Care and Clinical Studies....Pages 85-96
Serum Creatinine and other Measures of GFR in Diabetes....Pages 97-102
Familial Factors in Diabetic Nephropathy....Pages 103-111
Genetics and Diabetic Nephropathy....Pages 113-122
The Concept of Low Birth Weight and Renal Disease....Pages 123-130
Effects of Insulin on the Kidney and the Cardiovascular system....Pages 131-140
Diabetes, Hypertension, and Kidney Disease in the Pima Indians....Pages 141-150
Value of Screening for Microalbuminuria in People with Diabetes as Well as in the General Population....Pages 151-162
Incidence of Nephropathy in IDDM as Related to Mortality. Costs and Benefits of Early Intervention....Pages 163-170
Measurement of Albumin and other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance....Pages 171-180
Office Tests for Microalbuminuria....Pages 181-189
Exercise and the Kidney in Diabetes....Pages 191-197
Von Willebrand Factor, Dysfunction of the Vascular Endothelium, and the Development of Renal and Vascular Complications in Diabetes....Pages 199-208
Smoking and Diabetic Nephropathy....Pages 209-216
Light Microscopy of Diabetic Glomerulopathy: The Classic Lesions....Pages 217-226
Renal Ultrastructural Changes in Microalbuminuric IDDM-Patients....Pages 227-236
Renal Structure in Non Insulin Dependent Diabetic Patients with Microalbuminuria....Pages 237-247
Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy....Pages 249-256
Advanced Glycation End-Products and Diabetic Renal Disease....Pages 257-262
Protein Kinase C in Diabetic Renal Involvement, the Perspective of its Inhibition....Pages 263-268
Biochemical Aspects of Diabetic Nephropathy....Pages 269-279
The Steno Hypothesis and Glomerular Basement Membrane Biochemistry in Diabetic Nephropathy....Pages 281-288
Volume Homeostasis and Blood Pressure in Diabetic States....Pages 289-295
Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors....Pages 297-305
The Role of Growth Hormone, Insulin-Like Growth Factors, Epidermal Growth Factor and Transforming Growth Factor β in Diabetic Kidney Disease: An Update....Pages 307-319
Transforming Growth Factor-Beta and other Cytokines in Experimental and Human Diabetic Nephropathy....Pages 321-333
Blood Pressure Elevation in Diabetes: The Results From 24-H Ambulatory Blood Pressure Recordings....Pages 335-355
Lipidaemia and Diabetic Renal Disease....Pages 357-369
Microalbuminuria in Young Patients with Type 1 Diabetes....Pages 371-381
Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention....Pages 383-392
ACE Inhibition, Angiotensin II Receptor Blockade, and Diabetic Nephropathy....Pages 393-397
The Concept of Incipient Diabetic Nephropathy and Effect of Early Antihypertensive Intervention....Pages 399-407
Clinical Trials in Overt Diabetic Nephropathy....Pages 409-418
Antihypertensive Treatment in NIDDM, With Special Reference to Abnormal Albuminuria....Pages 419-434
The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Insulin Treatment....Pages 435-441
Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake....Pages 443-453
Microalbuminuria and Diabetic Pregnancy....Pages 455-462
Diabetic Nephropathy and Pregnancy....Pages 463-474
Evolution Worldwide of Renal Replacement Therapy in Diabetes....Pages 475-482
Hemodialysis in Type I and Type II Diabetic Patients with Endstage Renal Failure....Pages 483-490
Continuous Ambulatory Peritoneal Dialysis in Uremic Diabetics....Pages 491-523
Renal Transplantation for Diabetic Nephropathy....Pages 525-545
Prevention of Diabetic Renal Disease with Special Reference to Microalbuminuria....Pages 547-557
Combination Therapy for Hypertension and Renal Disease in Diabetes....Pages 559-568
Microalbuminuria in Patients with Essential Hypertension. Cardiovascular and Renal Implications....Pages 569-584
A Comparison of Progression in Diabetic and Non-Diabetic Renal Disease: Similarity of Progression Promoters....Pages 585-595
Back Matter....Pages 597-609