The Kidney and Hypertension in Diabetes Mellitus

Front Matter....Pages i-xxxviii
Pressure Induced and Metabolic Alterations in the Glomerulus: Role in Cytokine Activity and Progressive Sclerosis....Pages 1-11
Definition of Diabetic Renal Disease in Insulin Dependent Diabetes Mellitus Based on Renal Function Tests....Pages 13-28
Retinopathy in Relation to Albuminuria and Blood Pressure in IDDM....Pages 29-38
Microalbuminuria and Cardiovascular Disease....Pages 39-53
The Heart in Diabetes: Results of Trials....Pages 55-65
Albuminuria in Non-Insulin-Dependent Diabetes — Renal or “Extra” Renal Disease ?....Pages 67-79
The Clinical Course of Renal Disease in Caucasian NIDDM Patients....Pages 81-94
Serum Creatinine and Other Measures of GFR in Diabetes....Pages 95-101
Familial Factors in Diabetic Nephropathy....Pages 103-114
Genetics and Diabetic Nephropathy....Pages 115-128
Birth, Barker and Brenner: The Concept of Low Birth Weight and Renal Disease....Pages 129-139
Effects of Insulin on the Kidney and the Cardiovascular System....Pages 141-153
Value of Screening for Microalbuminuria in People with Diabetes as well as an the General Population....Pages 155-168
Incidence of Nephropathy in IDDM as Related to Mortality. Costs and Benefits of Early Intervention.....Pages 169-178
Dysfunction of the Vascular Endothelium and the Development of Renal and Vascular Complications in Diabetes....Pages 179-192
Urinary Tract Infections in Patients with Diabetes Mellitus....Pages 193-200
Light Microscopy of Diabetic Glomerulopathy: The Classic Lesions....Pages 201-210
Renal Structural Changes in Patients with Type 1 Diabetes and Microalbuminuria....Pages 211-223
Renal Structure in Type 2 Diabetic Patients with Microalbuminuria....Pages 225-236
Nephropathy in NIDDM Patients, Predictors of Outcome....Pages 237-246
Advanced Glycation End-Products and Diabetic Renal Disease....Pages 247-253
Protein Kinase C in Diabetic Renal Involvement, the Perspective of its Inhibition....Pages 255-262
Biochemical Aspects of Diabetic Nephropathy....Pages 263-279
Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors....Pages 281-294
An Update on the Role of Growth Factors in the Development of Diabetic Kidney Disease....Pages 295-311
Transforming Growth Factor-β and other Cytokines in Experimental and Human Nephropathy....Pages 313-338
Blood Pressure Elevation in Diabetes: The Results from 24-h Ambulatory Blood Pressure Recordings....Pages 339-362
Microalbuminuria in Young Patients with Type 1 Diabetes....Pages 363-379
Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention....Pages 381-393
Diabetes, Hypertension, and Kidney Disease in the Pima Indians....Pages 395-405
Autoregulation of Glomerular Filtration Rate in Patients with Diabetes....Pages 407-415
Ace Inhibition, Angiotensin II Receptor Blockade, and Diabetic Nephropathy....Pages 417-422
The Concept of Incipient Diabetic Nephropathy and Effect of Early Antihypertensive Intervention....Pages 423-433
Reversibility of Diabetic Nephropathy Lesions: A New Concept....Pages 435-440
Antihypertensive Treatment in NIDDM, with Special Reference to Abnormal Albuminuria....Pages 441-459
The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Treatment....Pages 461-471
Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake....Pages 473-485
Diabetic Nephropathy and Pregnancy....Pages 487-500
Evolution Worldwide of Renal Replacement Therapy in Diabetes....Pages 501-511
Hemodialysis and CAPD in Type I and Type II Diabetic Patients with Endstage Renal Failure....Pages 513-526
Renal Transplantation for Diabetic Nephropathy....Pages 527-557
Combination Therapy for Hypertension and Renal Disease in Diabetes....Pages 559-573
Microalbuminuria in Essential Hypertension. Significance for the Cardiovascular and Renal Systems....Pages 575-586
A Comparison of Progression in Diabetic and Non-Diabetic Renal Disease: Similarity of Progression Promoters....Pages 587-600
Update of the Latest Intervention Trials in Hypertension and Type 2 Diabetes....Pages 601-610
Scientific Basis for New Guidelines for the Treatment of Hypertension in Type 2 Diabetes....Pages 611-621
Regulatory Considerations in the Development of Therapies for Diabetic Nephropathy and Related Conditions....Pages 623-644
The Renin Angiotensin System in the Pahtogenesis of Diabetic Complications....Pages 645-654
Microalbuminuria, Blood Pressure and Diabetic Renal Disease: Origin and Development of Ideas....Pages 655-706
Back Matter....Pages 707-722