The Ischemic Heart

Front Matter....Pages i-xlvi
Front Matter....Pages 1-1
Function of Cardiac Myocytes in Ischemicheart Disease: Comparative Changes in Right and Left Ventricular Cells....Pages 3-12
Remodeling of Cardiac Myocytes in Chronic Heart Disease....Pages 13-22
Hibernating Myocardium....Pages 23-31
Length-Dependent Modulation of Cardiac Muscle Contractility in Normoxia, Hypoxia, and Acidosis: Possible Implications for Ischemia....Pages 33-40
Roles of Superoxide, Nitric Oxide, and Peroxynitrite in Various Pathological Conditions....Pages 41-56
Real-Time Measurement of Nitric Oxide in Coronary Outflow during Transient Myocardial Ischemia and Reperfusion....Pages 57-65
Production of Hydrogen Peroxide During Hypoxia-Reoxygenation in Isolated Myocytes....Pages 67-76
Oxygen Free Radicals Enhance Ergonovine-Induced Canine Coronary Vasoconstriction....Pages 77-86
Structure and Expression of Calponin in Arterial Smooth Muscle Cells....Pages 87-95
Status of β-Adrenoceptors, G-Proteins, and Adenylyl Cyclase in Ischemic Heart Disease....Pages 97-123
Oxygen Consumption and Mitochondrial Membrane Potential in Postischemic Myocardium....Pages 125-135
Pathophysiological Behavior of the Myocardium in Acute Ischemia and Reperfusion, with Special Emphasis on the Sarcoplasmic Reticulum....Pages 137-149
Ca 2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury....Pages 151-176
Ionic Mechanisms of Reperfusion Injury....Pages 177-188
Mechanism of Inhibition of Na + -H + Exchanger (NHE1) by ATP Depletion: Implications for Myocardial Ischemia....Pages 189-197
The Source and Fate of Protons in the Reperfused Ischemic Heart....Pages 199-213
Intracellular Calcium Regulation in Cardiac Cells during Acidosis....Pages 215-240
Intracellular pH Regulation and Myocardial Ischemia-Reperfusion Injury....Pages 241-247
Regulation of [Na + i and [Ca 2+ ] i during Myocardial Ischemia and Reperfusion in a Single-Cell Model....Pages 249-264
ATP-Sensitive Potassium Channels and Myocardial Ischemia....Pages 265-276
Front Matter....Pages 277-277
Early and Delayed Protection Against Ventricular Arrhythmias Induced by Preconditioning....Pages 279-303
Effects of Ischemic Preconditioning on Na + -Ca 2+ Exchanger Activity and Ion Regulation in Isolated Perfused Rat Hearts....Pages 305-316
Long-Term but not Short-Term Cardioprotection can be Induced by Preconditioning in Hypercholesterolemia....Pages 317-326
Contribution of Endogenous Catecholamines to Preconditioning: Is it through Facilitation of Adenosine Production?....Pages 327-336
Hypoxic Preconditioning of Isolated Cardiomyocytes of Adult Rat....Pages 337-349
Pharmacological Modification of Ischemic Preconditioning During Percutaneous Transluminal Coronary Angioplasty....Pages 351-356
Protection Against Injury Durin Gmyocardial Ischemia and Reperfusion: Concepts and Strategies....Pages 357-366
Mechanisms of Cardioprotective Effects of Propranolol Against Reperfusion Injury....Pages 367-377
Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion....Pages 379-386
Thioctic Acid Prevents Oxidativedamage in Isolated Cardiac Myocytes....Pages 387-397
Transfection of Heat-Shock Protein 70 Enhances Myocardial Tolerance to Ischemia: Evidence for a Role of HSP70 in Ischemia-Reperfusion Injury....Pages 399-409
Calcium but not Amiloride Improves the Mechanical Function of Reperfused One-Week-Old Rabbit Hearts....Pages 411-421
Effects of BIBR-277, an Angiotensin-II Type-1 Receptor Antagonist, on Ischemic Myocardial Stunning in Dogs....Pages 423-432
Reperfusion 12 Hours after Coronary Occlusion Salvages Myocardium in Dogs: Studies in a Single-Heart Model....Pages 433-440
Ecto-5′-Nucleotidase and Cardioprotection....Pages 441-450
Limitation of Stunning in Dog Myocardium by the Nucleoside-Nucleotide Mixture OG-VI....Pages 451-460
Decrease in Myocardial Ischemic Tolerance with Aging in Fischer 344 Rats....Pages 461-471
Underperfusion Injury in Diabetic Rat Hearts: Effects of Norepinephrine and/or Insulin on Stiffness Increase and Abnormal Energy Metabolism....Pages 473-500
Do Ketone Bodies Contribute to Protection against Damage Caused by Bothmyocardial Ischemia and Reperfusion Injury?....Pages 501-509
Effect of Basic Fibroblast Growth Factor on the Regional Myocardial Blood Flow of Acutely Infarctedmyocardium in Experimental Animals....Pages 511-518
Front Matter....Pages 277-277
Intramyocardial Ejection of Basic Fibroblast Growth Factor Increased Regional Myocardial Blood Flow Andsalvaged Infarcted Myocardium in Dogs....Pages 519-524
Effect of Basic Fibroblast Growth Factor on the Regional Myocardial Blood Flow in Acutely Infarcted Myocardium in Rats....Pages 525-529
Gene Therapy for Myocardial Infarction....Pages 531-544
Adenoviral Vectors as Experimental and Therapeutic Tools....Pages 545-550
Prevention of Transplantation-Associated Arteriosclerosis by Antiadhesion Therapy....Pages 551-562
Back Matter....Pages 563-575