The Implicit Genome

Contents......Page 9
Contributors......Page 11
An Overview of the Implicit Genome......Page 17
1. Sequence-Dependent Properties of DNA and Their Role in Function......Page 37
2. Mutation as a Phenotype......Page 53
3. Repeats and Variation in Pathogen Selection......Page 68
4. Tuning Knobs in the Genome: Evolution of Simple Sequence Repeats by Indirect Selection......Page 91
5. Implicit Information in Eukaryotic Pathogens as the Basis of Antigenic Variation......Page 105
6. The Role of Repeat Sequences in Bacterial Genetic Adaptation to Stress......Page 121
7. The Role of Mobile DNA in the Evolution of Prokaryotic Genomes......Page 135
8. Eukaryotic Transposable Elements: Teaching Old Genomes New Tricks......Page 152
9. Immunoglobulin Recombination Signal Sequences: Somatic and Evolutionary Functions......Page 177
10. Somatic Evolution of Antibody Genes......Page 191
11. Regulated and Unregulated Recombination of G-rich Genomic Regions......Page 205
12. The Role of the Genome in the Initiation of Meiotic Recombination......Page 222
13. Nuclear Duality and the Genesis of Unusual Genomes in Ciliated Protozoa......Page 239
14. Editing Informational Content of Expressed DNA Sequences and Their Transcripts......Page 262
15. Alternative Splicing: One Gene, Many Products......Page 280
16. Imprinting: The Hidden Genome......Page 296
Epilogue: An Engineering Perspective: The Implicit Protocols......Page 308
References......Page 313
List of Acronyms......Page 377
A......Page 379
B......Page 380
C......Page 381
D......Page 383
E......Page 385
F......Page 386
G......Page 387
H......Page 388
I......Page 389
M......Page 390
O......Page 392
P......Page 393
R......Page 394
S......Page 395
T......Page 397
W......Page 398
Z......Page 399